The DOI matches its Crossref record.
Group II intron domain 5 facilitates a trans-splicing reaction.
Open accessAbstract
A self-splicing group II intron of yeast mitochondrial DNA (aI5g) was divided within intron domain 4 to yield two RNAs that trans-spliced in vitro with associated trans-branching of excised intron fragments. Reformation of the domain 4 secondary structure was not necessary for the trans reaction, since domain 4 sequences were shown to be dispensable. Instead, the trans reaction depended on a previously unpredicted interaction between intron domain 5, the most highly conserved region of group II introns, and another region of the RNA. Domain 5 was shown to be essential for cleavage at the 5' splice site. It stimulated that cleavage when supplied as a trans-acting RNA containing only 42 nucleotides of intron sequence. The relevance of our findings to in vivo trans-splicing mechanisms is discussed.
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Cited by
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Steitz, T. A., & Steitz, J. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6498 · Cited by 1,171
On the Possibility of Constructive Neutral Evolution
Stoltzfus, A. (1999) · Journal of Molecular Evolution · doi:10.1007/pl00006540 · Cited by 533
Lambowitz, A. M., & Zimmerly, S. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.091600 · Cited by 448
Metadata
- Authors
- Jarrell, K. A., Dietrich, R. C., & Perlman, P. S.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1988-06
- Volume
- 8
- Issue
- 6
- Pages
- 2361-2366
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W1931304055
- Cited by
- 174
- References
- 0
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Group II intron domain 5 facilitates a trans-splicing reaction. https://app.cochat.ai/papers/10.1128/mcb.8.6.2361
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- Jarrell, K. A., Dietrich, R. C., & Perlman, P. S. (1988). Group II intron domain 5 facilitates a trans-splicing reaction. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.8.6.2361
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