The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
ACE1 regulates expression of the Saccharomyces cerevisiae metallothionein gene.
Open accessAbstract
Copper resistance in Saccharomyces cerevisiae is mediated, in large part, by the CUP1 locus, which encodes a low-molecular-weight, cysteine-rich metal-binding protein. Expression of the CUP1 gene is regulated at the level of transcriptional induction in response to high environmental copper levels. This report describes the isolation of a yeast mutant, ace1-1, which is defective in the activation of CUP1 expression upon exposure to exogenous copper. The ace1-1 mutation is recessive and lies in a genetic element that encodes a trans-acting CUP1 regulatory factor. The wild-type ACE1 gene was isolated by in vivo complementation and restores copper inducibility of CUP1 expression and copper resistance to the otherwise copper-sensitive ace1-1 mutant. Linkage analysis and gene deletion experiments verified that this gene represents the authentic ACE1 locus. ACE1 maps to the left arm of chromosome VII, 9 centimorgans centromere distal to lys5. The ACE1 gene appears to play a direct or indirect positive role in activation of CUP1 expression in response to elevated copper concentrations.
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Cites
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
DNA sequencing with chain-terminating inhibitors
Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572
Molecular Cloning. A Laboratory Manual
Wood, E. (1983) · Biochemical Education · doi:10.1016/0307-4412(83)90068-7 · Cited by 29,533
Transformation of intact yeast cells treated with alkali cations
Ito, H., Fukuda, Y., Murata, K., & Kimura, A. (1983) · Journal of Bacteriology · doi:10.1128/jb.153.1.163-168.1983 · Cited by 7,518
Sherman, F., Fink, G. R., & Hicks, J. B. (1979) · Cold Spring Harbor Laboratory eBooks · Cited by 7,430
[12] One-step gene disruption in yeast
Rothstein, R. J. (1983) · Methods in Enzymology · doi:10.1016/0076-6879(83)01015-0 · Cited by 3,204
High-frequency transformation of yeast: autonomous replication of hybrid DNA molecules.
Struhl, K., Stinchcomb, D. T., Scherer, S., & Davis, R. W. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.3.1035 · Cited by 1,456
Yeast transformation: a model system for the study of recombination.
Orr-Weaver, T. L., Szostak, J. W., & Rothstein, R. J. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.10.6354 · Cited by 1,455
[10] Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast
Guarente, L. (1983) · Methods in Enzymology · doi:10.1016/0076-6879(83)01013-7 · Cited by 1,071
Sequences that regulate the divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae.
Johnston, M., & Davis, R. W. (1984) · Molecular and Cellular Biology · doi:10.1128/mcb.4.8.1440 · Cited by 1,012
Cited by
Interactions of fungi with toxic metals
GADD, G. M. (1993) · New Phytologist · doi:10.1111/j.1469-8137.1993.tb03796.x · Cited by 1,154
Drescher, U., Kremoser, C., Handwerker, C., Löschinger, J., Noda, M., & Bonhoeffer, F. (1995) · Cell · doi:10.1016/0092-8674(95)90425-5 · Cited by 850
The Copper Chaperone for Superoxide Dismutase
Culotta, V. C., Klomp, L. W. J., Strain, J., Casareno, R. L. B., Krems, B., & Gitlin, J. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.23469 · Cited by 850
Glutathione Metabolic Genes Coordinately Respond to Heavy Metals and Jasmonic Acid in Arabidopsis
Xiang, C., & Oliver, D. J. (1998) · The Plant Cell · doi:10.1105/tpc.10.9.1539 · Cited by 668
Iyer, V., & Struhl, K. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07255.x · Cited by 416
Metadata
- Authors
- Thiele, D. J.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1988-07
- Volume
- 8
- Issue
- 7
- Pages
- 2745-2752
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2051010986
- Cited by
- 310
- References
- 26
- FWCI
- 4.32
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
