The DOI matches its Crossref record.
Key features of heat shock regulatory elements.
Open accessAbstract
The promoters of heat shock protein genes are among the best-studied inducible eucaryotic promoters. Regions responsible for heat regulation have been identified previously by deletion experiments with several different heat shock genes. In this paper the critical importance of two novel features of heat shock regulatory elements was investigated. First, the elements were modular and, as a consequence, displayed a characteristic 5-nucleotide periodicity produced by multiple GAA blocks that were arranged in alternating orientations and at 2-nucleotide intervals. Functional heat shock regulatory elements appeared to include three or more of these blocks. Second, the nucleotides at the two positions immediately upstream from GAA segments played an important role in defining the competence of regulatory elements.
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Cited by
Heat shock factors: integrators of cell stress, development and lifespan
Åkerfelt, M., Morimoto, R. I., & Sistonen, L. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2938 · Cited by 1,455
Regulation of H SF 1 Function in the Heat Stress Response: Implications in Aging and Disease
Anckar, J., & Sistonen, L. (2011) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060809-095203 · Cited by 773
Heat shock factor and the heat shock response
Sorger, P. K. (1991) · Cell · doi:10.1016/0092-8674(91)90452-5 · Cited by 603
Borkovich, K. A., Farrelly, F. W., Finkelstein, D. B., Taulien, J., & Lindquist, S. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.9.3919 · Cited by 641
Abravaya, K., Myers, M. P., Murphy, S. P., & Morimoto, R. I. (1992) · Genes & Development · doi:10.1101/gad.6.7.1153 · Cited by 538
Metadata
- Authors
- Amin, J., Ananthan, J., & Voellmy, R.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1988-09
- Volume
- 8
- Issue
- 9
- Pages
- 3761-3769
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2159271990
- Cited by
- 582
- References
- 0
- FWCI
- 11.31
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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