The DOI matches its Crossref record.
Specific binding of estrogen receptor to the estrogen response element.
Open accessAbstract
Gene transfer studies have shown that estrogen regulation of specific genes is mediated by estrogen response elements (ERE). We report that binding of the estrogen receptor to the ERE can be detected by a gel retardation (band shift) assay. This binding interaction was highly sequence and receptor specific. Methylation interference analysis showed that the ERE contact sites of estrogen receptor displayed a perfect twofold rotational symmetry. This is compatible with estrogen receptor binding to the ERE as a head-to-head dimer.
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Citations
Cited by
Connections and Regulation of the Human Estrogen Receptor
McDonnell, D. P., & Norris, J. D. (2002) · Science · doi:10.1126/science.1071884 · Cited by 579
The human oxytocin gene promoter is regulated by estrogens
Richard, S., & Zingg, H. H. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39297-x · Cited by 242
Gibson, D. A., & Saunders, P. T. K. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.026 · Cited by 107
Metadata
- Authors
- Klein-Hitpass, L., Tsai, S. Y., Greene, G. L., Clark, J. H., Tsai, M. J., & O'Malley, B. W.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1989-01
- Volume
- 9
- Issue
- 1
- Pages
- 43-49
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2151071712
- Cited by
- 205
- References
- 0
- FWCI
- 14.87
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Specific binding of estrogen receptor to the estrogen response element. https://app.cochat.ai/papers/10.1128/mcb.9.1.43
- The paper
- Klein-Hitpass, L., Tsai, S. Y., Greene, G. L., Clark, J. H., Tsai, M. J., & O'Malley, B. W. (1989). Specific binding of estrogen receptor to the estrogen response element. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.9.1.43
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
