The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Connections and Regulation of the Human Estrogen Receptor
Abstract
Estrogen regulates a plethora of functionally dissimilar processes in a broad range of tissues. Recent progress in the study of the molecular mechanism of action of estrogen(s) has revealed why different cells can respond to the same hormone in a different manner. Three of these findings are of particular importance: (i) There are two genetically and functionally distinct estrogen receptors that have distinct expression patterns in vivo; (ii) the positive and negative transcriptional activities of these receptors require them to engage transcription cofactors (coactivators or corepressors) in target cells; and (iii) not all cofactors are functionally equivalent, nor are they expressed in the same manner in all cells. Thus, although the estrogen receptor is required for a cell to respond to an estrogenic stimulus, the nature and extent of that response are determined by the proteins, pathways, and processes with which the receptor interacts.
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Cites
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Self-citation
Cited by
A transmembrane intracellular estrogen receptor mediates rapid cell signaling
Revankar, C. M., Cimino, D. F., Sklar, L. A., Arterburn, J. B., & Prossnitz, E. R. (2005) · Science · doi:10.1126/science.1106943 · Cited by 2,302
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The X-files in immunity: sex-based differences predispose immune responses
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Genomic Targets of Nuclear Estrogen Receptors
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Breast cancer diagnosis: Imaging techniques and biochemical markers
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Metadata
- Authors
- McDonnell, D. P., & Norris, J. D.
- Venue
- Science
- Published
- 2002-05-31
- Volume
- 296
- Issue
- 5573
- Pages
- 1642-1644
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2002842589
- Cited by
- 579
- References
- 26
- FWCI
- 21.68
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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