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The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues.
Open accessAbstract
The gene responsible for multidrug resistance (mdr), which encodes the P-glycoprotein, is a member of a multigene family. We have identified distinct mdr gene transcripts encoded by three separate mdr genes in the mouse. Expression levels of each mdr gene are dramatically different in various mouse tissues. Specific mdr RNA transcripts of approximately 4.5, 5, and 6 kilobases have been detected. Each of the mdr genes has a specific RNA transcript pattern. These results should be considered in relation to understanding the normal physiological function of the mdr multigene family.
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Cited by
Mechanisms of Cancer Drug Resistance
Gottesman, M. M. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.103929 · Cited by 2,643
Smit, J. J. M., Schinkel, A. H., Elferink, R. P. J. O., Groen, A. K., Wagenaar, E., van Deemter, L., Mol, C. A. A. M., Ottenhoff, R., van der Lugt, N. M. T., van Roon, M. A., et al. (1993) · Cell · doi:10.1016/0092-8674(93)90380-9 · Cited by 1,456
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McGrath, J. P., & Varshavsky, A. (1989) · Nature · doi:10.1038/340400a0 · Cited by 601
ABC transporters as mediators of drug resistance and contributors to cancer cell biology
Fletcher, J. I., Williams, R. T., Henderson, M. J., Norris, M. D., & Haber, M. (2016) · Drug Resistance Updates · doi:10.1016/j.drup.2016.03.001 · Cited by 423
Meijer, O. C. (1998) · Endocrinology · doi:10.1210/en.139.4.1789 · Cited by 375
Metadata
- Authors
- Croop, J. M., Raymond, M., Haber, D., Devault, A., Arceci, R. J., Gros, P., & Housman, D. E.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1989-03
- Volume
- 9
- Issue
- 3
- Pages
- 1346-1350
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W1858200607
- Cited by
- 463
- References
- 0
- FWCI
- 11.84
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Croop, J. M., Raymond, M., Haber, D., Devault, A., Arceci, R. J., Gros, P., & Housman, D. E. (1989). The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.9.3.1346
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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