ABC transporters as mediators of drug resistance and contributors to cancer cell biology

Fletcher, Jamie I.; Williams, Rebekka T.; Henderson, Michelle J.; Norris, Murray D.; Haber, Michelle

doi:10.1016/j.drup.2016.03.001

Cited by 423Drug Transport and Resistance MechanismsAntibiotic Resistance in BacteriaPharmacogenetics and Drug Metabolism

ABC transporters as mediators of drug resistance and contributors to cancer cell biology

Fletcher, Jamie I., Williams, Rebekka T., Henderson, Michelle J., Norris, Murray D., Haber, Michelle·2016·Drug Resistance Updates

DOI 10.1016/j.drup.2016.03.001

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Abstract

The extrusion of anticancer drugs by members of the ATP-binding cassette (ABC) transporter family is one of the most widely recognized mechanisms of multidrug resistance, and can be considered a hijacking of their normal roles in the transport of xenobiotics, metabolites and signaling molecules across cell membranes. While roles in cancer multidrug resistance have been clearly demonstrated for P-glycoprotein (P-gp), Breast Cancer Resistance Protein (BCRP) and Multidrug Resistance Protein 1 (MRP1), direct evidence for a role in multidrug resistance in vivo is lacking for other family members. A less well understood but emerging theme is the drug efflux-independent contributions of ABC transporters to cancer biology, supported by a growing body of evidence that their loss or inhibition impacts on the malignant potential of cancer cells in vitro and in vivo. As with multidrug resistance, these contributions likely represent a hijacking of normal ABC transporter functions in the efflux of endogenous metabolites and signaling molecules, however they may expand the clinical relevance of ABC transporters beyond P-gp, BCRP and MRP1. This review summarizes established and emerging roles for ABC transporters in cancer, with a focus on neuroblastoma and ovarian cancer, and considers approaches to validate and better understand these roles.

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Upregulation of MDR1 has been shown to convey drug resistance to many anti-cancer drugs including chemotherapy agents, kinase inhibitors, and other targeted agents.
“Upregulation of the drug efflux pump encoded by ABCB1—MDR1 (multidrug resistance 1), a member of the superfamily of ATP-binding cassette (ABC) transporters—has been shown to convey drug resistance to many anti-cancer drugs including chemotherapy agents, kinase inhibitors, and other targeted agents (12).”
From The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells (2022) · cites this paper as [12]

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The Interaction of ApoA-I and ABCA1 Triggers Signal Transduction Pathways to Mediate Efflux of Cellular Lipids
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Chemotherapeutic Drug-Induced ABCG2 Promoter Demethylation as a Novel Mechanism of Acquired Multidrug Resistance
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Expression of Multidrug Resistance–Associated Proteins Predicts Prognosis in Childhood and Adult Acute Lymphoblastic Leukemia
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Revisiting the role of ABC transporters in multidrug-resistant cancer
Robey, R. W., Pluchino, K. M., Hall, M. D., Fojo, A. T., Bates, S. E., & Gottesman, M. M. (2018) · Nature Reviews Cancer · doi:10.1038/s41568-018-0005-8 · Cited by 1,866 · see citing works
Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy
Niu, B., Liao, K., Zhou, Y., Wen, T., Quan, G., Pan, X., & Wu, C. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121110 · Cited by 1,168 · see citing works
Resistance to tyrosine kinase inhibitors in chronic myeloid leukemia-from molecular mechanisms to clinical relevance
Alves, R., Gonçalves, A. C., Rutella, S., Almeida, A. M., De Las Rivas, J., Trougakos, I. P., & Sarmento Ribeiro, A. B. (2021) · Cancers · doi:10.3390/cancers13194820 · Cited by 204 · see citing works
Not only P-glycoprotein: Amplification of the ABCB1- containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins
Genovese, I., Ilari, A., Assaraf, Y. G., Fazi, F., & Colotti, G. (2017) · Drug Resistance Updates · doi:10.1016/j.drup.2017.10.003 · Cited by 156 · see citing works
The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells
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Targeting multidrug resistance-associated protein 1 (MRP1)-expressing cancers: Beyond pharmacological inhibition
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The Role of Solute Carrier Transporters in Efficient Anticancer Drug Delivery and Therapy
Puris, E., Fricker, G., & Gynther, M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020364 · Cited by 58 · see citing works

Mechanisms of resistance to anticancer drugs: the role of the polymorphic ABC transporters ABCB1 and ABCG2
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Effects of Two Natural Bisbenzylisoquinolines, Curine and Guattegaumerine, Extracted from Isolona hexaloba on Rhodamine Efflux by Abcb1b from Rat Glycocholic-Acid-Resistant Hepatocarcinoma Cells
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Antimicrobial Resistance: Two-Component Regulatory Systems and Multidrug Efflux Pumps
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Effect of β-elemene on the kinetics of intracellular transport of d-luciferin potassium salt (ABC substrate) in doxorubicin-resistant breast cancer cells and the associated molecular mechanism
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Interplay of Drug Metabolizing CYP450 Enzymes and ABC Transporters in the Blood-Brain Barrier
Declèves, X., Jacob, A., Yousif, S. H., et al. (2011) · Current Drug Metabolism · doi:10.2174/138920011798357024 · Cited by 98 · see citing works

Authors: Fletcher, J. I., Williams, R. T., Henderson, M. J., Norris, M. D., & Haber, M.
Affiliations: Children's Cancer Institute Australia (AU)
Corresponding author: Haber, Michelle
ORCID: Fletcher, Jamie I.
Henderson, Michelle J.
Norris, Murray D.
Haber, Michelle
Venue: Drug Resistance Updates
Publisher: Elsevier BV
Published: 2016-05
Volume: 26
Pages: 1-9
ISSN: 1368-7646 (ISSN-L)
DOI: 10.1016/j.drup.2016.03.001
OpenAlex: W2308408790
Cited by: 423
References: 139
Citations by year: 2026: 19 · 2025: 39 · 2024: 40 · 2023: 53 · 2022: 43 · 2021: 58 · 2020: 65 · 2019: 38 · 2018: 40 · 2017: 20 · 2016: 8
FWCI: 3.55
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Drug Resistance Updates (publishedVersion)
PubMed (publishedVersion)
Funders: Cancer Australia
University of New South Wales
Topics: Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Keywords: ABC transporters, multidrug resistance, P-glycoprotein, ABCG2, MRP1, drug efflux, cancer cell biology, neuroblastoma, ovarian cancer, ABC transporter inhibition
MeSH terms: Animals, Antineoplastic Agents, Biological Transport, Female, Humans, Neuroblastoma, Ovarian Neoplasms, Drug Resistance, Multiple, ATP-Binding Cassette Transporters, Drug Resistance, Neoplasm

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ABC transporters as mediators of drug resistance and contributors to cancer cell biology

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