The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Induction of the TRPM-2 gene in cells undergoing programmed death.
Open accessAbstract
RNA and protein products encoded by the testosterone-repressed prostate message-2 gene (TRPM-2) are induced to high levels, coordinate with the onset of cell death, in numerous rodent models of inducible tissue damage. These models include cell death initiated by hormonal stimuli (prostate regression), pressure insult (renal atrophy after ureteral obstruction), developmental stimuli (necrosis of interdigital tissue), and cytotoxic injury (chemotherapeutic regression of a tumor). Sequence analysis of cDNA encoding TRPM-2 revealed its close homology with a product referred to as SGP-2 or clusterin expressed constitutively by Sertoli cells; however, the immunologically related polypeptides expressed in regressing tissues differ in molecular mass from the forms secreted by the testis. Although the function(s) of the products encoded by the TRPM-2 gene remains unclear, their presence provides a remarkable and early indicator of programmed cell death in many types of mammalian cells.
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Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Genetic control of programmed cell death in the nematode C. elegans
Ellis, H. (1986) · Cell · doi:10.1016/0092-8674(86)90004-8 · Cited by 1,828
Cited by
Freeman, R. S., Estus, S., & Johnson, E. M. (1994) · Neuron · doi:10.1016/0896-6273(94)90276-3 · Cited by 573
Programmed Cell Death in the Immune System
Cohen, J. J. (1991) · Advances in Immunology · doi:10.1016/s0065-2776(08)60822-6 · Cited by 560
Clusterin Has Chaperone-like Activity Similar to That of Small Heat Shock Proteins
Humphreys, D. T., Carver, J. A., Easterbrook-Smith, S. B., & Wilson, M. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.11.6875 · Cited by 455
Roy, A. K., Lavrovsky, Y., Song, C. S., Chen, S., Jung, M. H., Velu, N. K., Bi, B. Y., & Chatterjee, B. (1998) · Vitamins & Hormones · doi:10.1016/s0083-6729(08)60938-3 · Cited by 411
May, P. C., Lampert-Etchells, M., Johnson, S. A., Poirier, J., Masters, J. N., & Finch, C. E. (1990) · Neuron · doi:10.1016/0896-6273(90)90342-d · Cited by 339
Metadata
- Authors
- Buttyan, R., Olsson, C. A., Pintar, J., Chang, C., Bandyk, M., Ng, P. Y., & Sawczuk, I. S.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1989-08
- Volume
- 9
- Issue
- 8
- Pages
- 3473-3481
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2178615409
- Cited by
- 452
- References
- 2
- FWCI
- 13.75
- Type
- journal article
- Language
- en
- Open access
- green
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- Buttyan, R., Olsson, C. A., Pintar, J., Chang, C., Bandyk, M., Ng, P. Y., & Sawczuk, I. S. (1989). Induction of the TRPM-2 gene in cells undergoing programmed death. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.9.8.3473
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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