Dynamics of gene expression for a hippocampal glycoprotein elevated in Alzheimer's disease and in response to experimental lesions in rat
Abstract
A hippocampal poly(A) RNA, pADHC-9, was cloned by differential screening of a human hippocampal cDNA library. By RNA blot analysis, pADHC-9 was elevated 2-fold in Alzheimer's disease hippocampus. In situ analyses identified pADHC-9 expression in pyramidal and non-pyramidal cells of the hippocampus and entorhinal cortex. Nucleotide sequence analysis identified pADHC-9 as a potential human homolog of rat sulfated glycoprotein 2 (SGP-2). SGP-2 expression increased in rat hippocampus following experimental lesions that mimic intrinsic neuronal loss and/or deafferentation. The function of pADHC-9 in brain has not been defined, but in serum, a similar protein inhibits complement-dependent cytolysis. Increased expression of pADHC-9 in Alzheimer's disease hippocampus may be a compensatory response mounted to retard a complement-driven neurodegenerative cascade.
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Clusterin was first linked to Alzheimer's disease in 1990, when it was found elevated in the hippocampi of AD patients.
“CLU was first associated with Alzheimer’s disease (AD) in 1990 when it was found to be increased in the hippocampi of AD patients (May, et al., 1990)”
From A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin (2016) · cites this paper as May, et al., 1990
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- Authors
- May, P. C., Lampert-Etchells, M., Johnson, S. A., Poirier, J., Masters, J. N., & Finch, C. E.
- Affiliations
- University of Southern California (US)
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1990-12
- Volume
- 5
- Issue
- 6
- Pages
- 831-839
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2004102314
- Cited by
- 339
- References
- 30
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 7 · 2023: 5 · 2022: 4 · 2021: 7 · 2020: 6 · 2019: 10 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 10 · 2014: 11 · 2013: 10 · 2012: 12
- FWCI
- 15.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG 05142, P50AG005142)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, hippocampus, gene expression, sulfated glycoprotein-2, polyadenylated RNA, entorhinal cortex, experimental brain lesions, deafferentation, neuronal loss, complement-dependent cytotoxicity, neurodegeneration, compensatory response
- MeSH terms
- Alzheimer Disease, Autoradiography, Cloning, Molecular, Denervation, DNA, Glycoproteins, Hippocampus, Humans, Male, Nucleic Acid Hybridization, RNA, Transcription, Genetic, DNA Probes, Gene Expression, Molecular Chaperones, Clusterin
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