The DOI matches its Crossref record; 316 of the 316 references it cites were found in a registry or an index.
Replication Fork Stalling at Natural Impediments
Open accessAbstract
SUMMARY: Accurate and complete replication of the genome in every cell division is a prerequisite of genomic stability. Thus, both prokaryotic and eukaryotic replication forks are extremely precise and robust molecular machines that have evolved to be up to the task. However, it has recently become clear that the replication fork is more of a hurdler than a runner: it must overcome various obstacles present on its way. Such obstacles can be called natural impediments to DNA replication, as opposed to external and genetic factors. Natural impediments to DNA replication are particular DNA binding proteins, unusual secondary structures in DNA, and transcription complexes that occasionally (in eukaryotes) or constantly (in prokaryotes) operate on replicating templates. This review describes the mechanisms and consequences of replication stalling at various natural impediments, with an emphasis on the role of replication stalling in genomic instability.
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“collapse of the replication forks may result in DSBs [59].”
From Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A (2009) · cites this paper as [59]
In the citing paper
“DSBs can be generated at stalled forks [59,62-64] that contain strand termini of double-stranded/single-stranded DNA (ds-ssDNA) junctions, mostly from Okazaki fragments.”
From Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A (2009) · cites this paper as [59]
Citations
Cites
MACDONALD, M. (1993) · Cell · doi:10.1016/0092-8674(93)90585-e · Cited by 8,366
The complete genome sequence of Escherichia coli K-12.
Blattner, F., Plunkett, G., Bloch, C., Perna, N., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C., Mayhew, G., et al. (1997) · Science · doi:10.1126/science.277.5331.1453 · Cited by 7,996
Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. (2005) · doi:10.1128/9781555816704 · Cited by 5,683
Spellman, P. T., Sherlock, G. J., Zhang, M. Q., Iyer, V. R., Anders, K. R., Eisen, M. B., Brown, P. O., Botstein, D., & Futcher, B. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.12.3273 · Cited by 4,724
Escherichia Coli and Salmonella: Typhimurium Cellular and Molecular Biology
Neidhardt, F. C., & Ingraham, J. L. (1987) · Medical Entomology and Zoology · Cited by 4,089
Verkerk, A. J. M. H., Pieretti, M., Sutcliffe, J. S., Fu, Y.-H., Kuhl, D. P. A., Pizzuti, A., Reiner, O., Richards, S., Victoria, M. F., Zhang, F., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90397-h · Cited by 3,481
Shah, M. A., Datson, N. A., Srinidhi, L., Stanton, V. P., MacDonald, M. E., Allard, M. W., Youngman, S., Am, F., Mott, R., Draths, K., et al. (1993) · Cell · Cited by 3,055
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
Fishel, R. A., Lescoe, M. K., Rao, M. R. S., Copeland, N. G., Jenkins, N. A., Garber, J. E., Kane, M., & Kolodner, R. D. (1993) · Cell · doi:10.1016/0092-8674(93)90546-3 · Cited by 2,884
Friedreich's Ataxia: Autosomal Recessive Disease Caused by an Intronic GAA Triplet Repeat Expansion
Campuzano, V., Montermini, L., Moltò, M. D., Pianese, L., Cossée, M., Cavalcanti, F., Monros, E., Rodius, F., Duclos, F., Monticelli, A., et al. (1996) · Science · doi:10.1126/science.271.5254.1423 · Cited by 2,786
Brook, J. D., McCurrach, M. E., Harley, H. G., Buckler, A., Church, D. M., Aburatani, H., Hunter, K. W., Stanton, V. P., Thirion, J., Hudson, T. J., et al. (1992) · Cell · doi:10.1016/0092-8674(92)90154-5 · Cited by 2,754
Research works printed but not linked: 6
- DePamphilis, M. L. 2002. Eukaryotic DNA replication fork. Chemtracts Biochem. Mol. Biol.15:313-325.
- Freudenreich, C. H. 2005. Molecular mechanisms of chromosomal fragility. Chemtracts Biochem. Mol. Biol.18:141-152.
- Mirkin, S. M. 2004. Molecular models for repeat expansions. Chemtracts Biochem. Mol. Biol.17:639-662.
- Mirkin, S. M. 2006. Replication of expandable repeats, p. 637-644. In R. D. Wells and T. Ashizawa (ed.), Genetic instabilities and neurological diseases, 2nd ed. Academic Press, New York, NY.
- 10.1128/mcb.9.8.3464-3472.1989 · DOI
- Wells R. D. and S. T. Warren (ed.). 1998. Genetic instabilities and hereditary neurological disorders. Academic Press San Diego CA.
Cited by
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ATR: an essential regulator of genome integrity
Cimprich, K. A., & Cortez, D. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2450 · Cited by 1,798
R Loops: From Transcription Byproducts to Threats to Genome Stability
Aguilera, A., & García‐Muse, T. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.04.009 · Cited by 1,029
Maintaining genome stability at the replication fork
Branzei, D., & Foiani, M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2852 · Cited by 786
Sources of DNA Double-Strand Breaks and Models of Recombinational DNA RepairPreprint
Mehta, A., & Haber, J. E. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016428 · Cited by 792
Hamperl, S., Bocek, M. J., Saldivar, J. C., Swigut, T., & Cimprich, K. A. (2017) · Cell · doi:10.1016/j.cell.2017.07.043 · Cited by 678
Metadata
- Authors
- Mirkin, E. V., & Mirkin, S. M.
- Affiliations
- University of Illinois Chicago (US)
- ORCID
- Mirkin, Sergei M.
- Venue
- Microbiology and Molecular Biology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2007-03
- Volume
- 71
- Issue
- 1
- Pages
- 13-35
- ISSN
- 1092-2172 (ISSN-L)
- 1098-5557
- PMC
- PMC1847372
- OpenAlex
- W2160336344
- Cited by
- 482
- References
- 316
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 14 · 2023: 23 · 2022: 15 · 2021: 28 · 2020: 42 · 2019: 30 · 2018: 32 · 2017: 27 · 2016: 38 · 2015: 22 · 2014: 34 · 2013: 29 · 2012: 32
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Microbiology and Molecular Biology Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM060987, GM60987)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- replication fork stalling, DNA replication, genomic instability, DNA-binding proteins, DNA secondary structure, replication fork reversal
- MeSH terms
- Animals, DNA Replication, DNA-Binding Proteins, Humans, Models, Genetic, Transcription, Genetic, Replication Origin, Saccharomyces cerevisiae Proteins, Escherichia coli Proteins, Genomic Instability
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