Cited by 482DNA Repair MechanismsBacterial Genetics and BiotechnologyDNA and Nucleic Acid Chemistry

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Replication Fork Stalling at Natural Impediments

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Mirkin, Ekaterina V., Mirkin, Sergei M.·2007·Microbiology and Molecular Biology Reviews

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Abstract

SUMMARY: Accurate and complete replication of the genome in every cell division is a prerequisite of genomic stability. Thus, both prokaryotic and eukaryotic replication forks are extremely precise and robust molecular machines that have evolved to be up to the task. However, it has recently become clear that the replication fork is more of a hurdler than a runner: it must overcome various obstacles present on its way. Such obstacles can be called natural impediments to DNA replication, as opposed to external and genetic factors. Natural impediments to DNA replication are particular DNA binding proteins, unusual secondary structures in DNA, and transcription complexes that occasionally (in eukaryotes) or constantly (in prokaryotes) operate on replicating templates. This review describes the mechanisms and consequences of replication stalling at various natural impediments, with an emphasis on the role of replication stalling in genomic instability.

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DePamphilis, M. L. 2002. Eukaryotic DNA replication fork. Chemtracts Biochem. Mol. Biol.15:313-325.
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Authors: Mirkin, E. V., & Mirkin, S. M.
Affiliations: University of Illinois Chicago (US)
ORCID: Mirkin, Sergei M.
Venue: Microbiology and Molecular Biology Reviews
Publisher: American Society for Microbiology
Published: 2007-03
Volume: 71
Issue: 1
Pages: 13-35
ISSN: 1092-2172 (ISSN-L)
1098-5557
DOI: 10.1128/mmbr.00030-06
PMC: PMC1847372
OpenAlex: W2160336344
Cited by: 482
References: 316
Citations by year: 2026: 9 · 2025: 12 · 2024: 14 · 2023: 23 · 2022: 15 · 2021: 28 · 2020: 42 · 2019: 30 · 2018: 32 · 2017: 27 · 2016: 38 · 2015: 22 · 2014: 34 · 2013: 29 · 2012: 32
FWCI: 1.62
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Microbiology and Molecular Biology Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (R01GM060987, GM60987)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Keywords: replication fork stalling, DNA replication, genomic instability, DNA-binding proteins, DNA secondary structure, replication fork reversal
MeSH terms: Animals, DNA Replication, DNA-Binding Proteins, Humans, Models, Genetic, Transcription, Genetic, Replication Origin, Saccharomyces cerevisiae Proteins, Escherichia coli Proteins, Genomic Instability

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Replication Fork Stalling at Natural Impediments

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