The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Role of Pore-Forming Toxins in Bacterial Infectious Diseases
Open accessAbstract
SUMMARY: Pore-forming toxins (PFTs) are the most common bacterial cytotoxic proteins and are required for virulence in a large number of important pathogens, including Streptococcus pneumoniae, group A and B streptococci,Staphylococcus aureus,Escherichia coli, and Mycobacterium tuberculosis. PFTs generally disrupt host cell membranes, but they can have additional effects independent of pore formation. Substantial effort has been devoted to understanding the molecular mechanisms underlying the functions of certain model PFTs. Likewise, specific host pathways mediating survival and immune responses in the face of toxin-mediated cellular damage have been delineated. However, less is known about the overall functions of PFTs during infection in vivo. This review focuses on common themes in the area of PFT biology, with an emphasis on studies addressing the roles of PFTs in in vivo and ex vivo models of colonization or infection. Common functions of PFTs include disruption of epithelial barrier function and evasion of host immune responses, which contribute to bacterial growth and spreading. The widespread nature of PFTs make this group of toxins an attractive target for the development of new virulence-targeted therapies that may have broad activity against human pathogens.
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Cites
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Cited by
Pore-forming toxins: ancient, but never really out of fashion
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Iron acquisition strategies of bacterial pathogens
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Tissue damage control in disease tolerance
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Iron Acquisition Strategies of Bacterial Pathogens
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Metadata
- Authors
- Los, F. C. O., Randis, T. M., Aroian, R. V., & Ratner, A. J.
- Venue
- Microbiology and Molecular Biology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2013-06
- Volume
- 77
- Issue
- 2
- Pages
- 173-207
- ISSN
- 1092-2172 (ISSN-L)
- 1098-5557
- OpenAlex
- W2123109660
- Cited by
- 402
- References
- 19
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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