The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Bio-inspired detoxification using 3D-printed hydrogel nanocomposites
Open accessAbstract
Rationally designed nanoparticles that can bind toxins show great promise for detoxification. However, the conventional intravenous administration of nanoparticles for detoxification often leads to nanoparticle accumulation in the liver, posing a risk of secondary poisoning especially in liver-failure patients. Here we present a liver-inspired three-dimensional (3D) detoxification device. This device is created by 3D printing of designer hydrogels with functional polydiacetylene nanoparticles installed in the hydrogel matrix. The nanoparticles can attract, capture and sense toxins, while the 3D matrix with a modified liver lobule microstructure allows toxins to be trapped efficiently. Our results show that the toxin solution completely loses its virulence after treatment using this biomimetic detoxification device. This work provides a proof-of-concept of detoxification by a 3D-printed biomimetic nanocomposite construct in hydrogel, and could lead to the development of alternative detoxification platforms. Nanoparticles capable of selectively binding target chemicals have potential for detoxification processes, but can lead to accumulation in the liver. Here the authors show a 3D-printed device containing functional nanoparticles, allowing the detox potential to be realised while holding the particles in place.
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Cites
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Cited by
3D printing of functional biomaterials for tissue engineering
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Self-citationHydrogels and Their Applications in Targeted Drug Delivery
Narayanaswamy, R., & Torchilin, V. P. (2019) · Molecules · doi:10.3390/molecules24030603 · Cited by 664
3D printing of highly stretchable hydrogel with diverse UV curable polymers
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Recent Advances in Photo-Crosslinkable Hydrogels for Biomedical Applications
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Metadata
- Authors
- Gou, M., Qu, X., Zhu, W., Xiang, M., Yang, J., Zhang, K., Wei, Y., & Chen, S.
- Venue
- Nature Communications
- Published
- 2014-05-08
- Volume
- 5
- Issue
- 1
- Pages
- 3774-3774
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2038202065
- Cited by
- 323
- References
- 40
- FWCI
- 12.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Gou, M., Qu, X., Zhu, W., Xiang, M., Yang, J., Zhang, K., Wei, Y., & Chen, S. (2014). Bio-inspired detoxification using 3D-printed hydrogel nanocomposites. Nature Communications. https://doi.org/10.1038/ncomms4774
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