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Expression of virus-encoded proteinases: functional and structural similarities with cellular enzymes
Open accessAbstract
Many viruses express their genome, or part of their genome, initially as a polyprotein precursor that undergoes proteolytic processing. Molecular genetic analyses of viral gene expression have revealed that many of these processing events are mediated by virus-encoded proteinases. Biochemical activity studies and structural analyses of these viral enzymes reveal that they have remarkable similarities to cellular proteinases. However, the viral proteinases have evolved unique features that permit them to function in a cellular environment. In this article, the current status of plant and animal virus proteinases is described along with their role in the viral replication cycle. The reactions catalyzed by viral proteinases are not simple enzyme-substrate interactions; rather, the processing steps are highly regulated, are coordinated with other viral processes, and frequently involve the participation of other factors.
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Cites
Complete mutagenesis of the HIV-1 protease
Loeb, D. D., Swanstrom, R., Everitt, L., Manchester, M., Stamper, S. E., & Hutchison, C. A. (1989) · Nature · doi:10.1038/340397a0 · Cited by 327
Ansardi, D. C., Porter, D. C., & Morrow, C. D. (1991) · Journal of Virology · doi:10.1128/jvi.65.4.2088-2092.1991 · Cited by 64
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Varshavsky, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12142 · Cited by 859
Tasaki, T., Sriram, S. M., Park, K. S., & Kwon, Y. T. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-051710-093308 · Cited by 386
The N‐end rule pathway of protein degradation
Varshavsky, A. (1997) · Genes to Cells · doi:10.1046/j.1365-2443.1997.1020301.x · Cited by 367
Picornaviral 3C cysteine proteinases have a fold similar to chymotrypsin-like serine proteinases
Allaire, M., Chernaia, M. M., Malcolm, B. A., & James, M. N. G. (1994) · Nature · doi:10.1038/369072a0 · Cited by 306
An Antiviral Mechanism of Nitric Oxide
Saura, M., Zaragoza, C., McMillan, A., Quick, R. A., Hohenadl, C., Lowenstein, J. M., & Lowenstein, C. J. (1999) · Immunity · doi:10.1016/s1074-7613(00)80003-5 · Cited by 245
Metadata
- Authors
- Dougherty, W. G., & Semler, B. L.
- Venue
- Microbiological Reviews
- Publisher
- American Society for Microbiology
- Published
- 1993-01-01
- Volume
- 57
- Issue
- 4
- Pages
- 781-822
- ISSN
- 0146-0749 (ISSN-L)
- OpenAlex
- W2108301842
- Cited by
- 345
- References
- 2
- FWCI
- 12.93
- Type
- journal article
- Language
- en
- Open access
- diamond
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- Dougherty, W. G., & Semler, B. L. (1993). Expression of virus-encoded proteinases: functional and structural similarities with cellular enzymes. Microbiological Reviews. https://doi.org/10.1128/mmbr.57.4.781-822.1993
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