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The Where, When, and How of Organelle Acidification by the Yeast Vacuolar H + -ATPase
Open accessAbstract
SUMMARY: All eukaryotic cells contain multiple acidic organelles, and V-ATPases are central players in organelle acidification. Not only is the structure of V-ATPases highly conserved among eukaryotes, but there are also many regulatory mechanisms that are similar between fungi and higher eukaryotes. These mechanisms allow cells both to regulate the pHs of different compartments and to respond to changing extracellular conditions. The Saccharomyces cerevisiae V-ATPase has emerged as an important model for V-ATPase structure and function in all eukaryotic cells. This review discusses current knowledge of the structure, function, and regulation of the V-ATPase in S. cerevisiae and also examines the relationship between biosynthesis and transport of V-ATPase and compartment-specific regulation of acidification.
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Cunningham, K. W., & Fink, G. R. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.5.2226 · Cited by 431
Cited by
Regulation and Isoform Function of the V-ATPases
Toei, M., Saum, R., & Forgac, M. (2010) · Biochemistry · doi:10.1021/bi100397s · Cited by 391
Adaptive Response and Tolerance to Weak Acids in Saccharomyces cerevisiae : A Genome-Wide View
Mira, N. P., Teixeira, M. C., & Sá-Correia, I. (2010) · OMICS: A Journal of Integrative Biology · doi:10.1089/omi.2010.0072 · Cited by 295
Vacuolar and plasma membrane proton pumps collaborate to achieve cytosolic pH homeostasis in yeast
Martínez-Muñoz, G. A., & Kane, P. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710470200 · Cited by 257
Self-citationIntracellular pH is a tightly controlled signal in yeast
Orij, R., Brul, S., & Smits, G. J. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.03.011 · Cited by 243
Merz, S., & Westermann, B. (2009) · Genome Biology · doi:10.1186/gb-2009-10-9-r95 · Cited by 213
Metadata
- Authors
- Kane, P. M.
- Venue
- Microbiology and Molecular Biology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2006-03
- Volume
- 70
- Issue
- 1
- Pages
- 177-191
- ISSN
- 1092-2172 (ISSN-L)
- 1098-5557
- OpenAlex
- W2132694729
- Cited by
- 390
- References
- 1
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Kane, P. M. (2006). The Where, When, and How of Organelle Acidification by the Yeast Vacuolar H + -ATPase. Microbiology and Molecular Biology Reviews. https://doi.org/10.1128/mmbr.70.1.177-191.2006
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