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Cited by 1,812

The DOI matches its OpenAlex record; 2 of the 2 references it cites were found in a registry or an index.

Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia

Open access
John R. W. Govan, Vojo P. Deretic·1996·Microbiological Reviews

Abstract

Respiratory infections with Pseudomonas aeruginosa and Burkholderia cepacia play a major role in the pathogenesis of cystic fibrosis (CF). This review summarizes the latest advances in understanding host-pathogen interactions in CF with an emphasis on the role and control of conversion to mucoidy in P. aeruginosa, a phenomenon epitomizing the adaptation of this opportunistic pathogen to the chronic chourse of infection in CF, and on the innate resistance to antibiotics of B. cepacia, person-to-person spread, and sometimes rapidly fatal disease caused by this organism. While understanding the mechanism of conversion to mucoidy in P. aeruginosa has progressed to the point where this phenomenon has evolved into a model system for studying bacterial stress response in microbial pathogenesis, the more recent challenge with B. cepacia, which has emerged as a potent bona fide CF pathogen, is discussed in the context of clinical issues, taxonomy, transmission, and potential modes of pathogenicity.

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Registry

OpenAlex · 10.1128/mmbr.60.3.539-574.1996

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Metadata

Authors
Govan, J. R. W., & Deretic, V. P.
Venue
Microbiological Reviews
Publisher
American Society for Microbiology
Published
1996-01-01
Volume
60
Issue
3
Pages
539-574
ISSN
0146-0749 (ISSN-L)
OpenAlex
W2169545551
Cited by
1,812
References
2
FWCI
12.12
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia. https://app.cochat.ai/papers/10.1128/mmbr.60.3.539-574.1996
The paper
Govan, J. R. W., & Deretic, V. P. (1996). Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia. Microbiological Reviews. https://doi.org/10.1128/mmbr.60.3.539-574.1996

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.