Synthesis of polycaprolactone: A review

Labet, Marianne; Thielemans, Wim

doi:10.1039/b820162p

Cited by 1,673biodegradable polymer synthesis and propertiesCarbon dioxide utilization in catalysisPolymer crystallization and properties

Synthesis of polycaprolactone: A review

Labet, Marianne, Thielemans, Wim·2009·Chemical Society Reviews

DOI 10.1039/b820162p

Open this paper in CoChat — free account

Abstract

Polycaprolactone (PCL) is an important polymer due to its mechanical properties, miscibility with a large range of other polymers and biodegradability. Two main pathways to produce polycaprolactone have been described in the literature: the polycondensation of a hydroxycarboxylic acid: 6-hydroxyhexanoic acid, and the ring-opening polymerisation (ROP) of a lactone: epsilon-caprolactone (epsilon-CL). This critical review summarises the different conditions which have been described to synthesise PCL, and gives a broad overview of the different catalytic systems that were used (enzymatic, organic and metal catalyst systems). A surprising variety of catalytic systems have been studied, touching on virtually every section of the periodic table. A detailed list of reaction conditions and catalysts/initiators is given and reaction mechanisms are presented where known. Emphasis is put on the ROP pathway due to its prevalence in the literature and the superior polymer that is obtained. In addition, ineffective systems that have been tried to catalyse the production of PCL are included in the electronic supplementary information for completeness (141 references).

Integrity signals

Registry

Crossref · 10.1039/b820162p

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

PCL has emerged as a promising synthetic biomaterial for postoperative anti-adhesion barrier films due to its biodegradability, mechanical flexibility, and controlled degradation rate.
“Polycaprolactone (PCL) has emerged as a promising synthetic biomaterial for postoperative anti-adhesion barrier films due to its biodegradability, mechanical flexibility, and controlled degradation rate [192].”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [192]

Biocompatible Initiators for Lactide Polymerization
Platel, R., Hodgson, L., & Williams, C. (2008) · Polymer Reviews · doi:10.1080/15583720701834166 · Cited by 706 · see citing works
Controlled Ring-Opening Polymerization of ε-Caprolactone Promoted by “in Situ” Formed Yttrium Alkoxides
Martin, E., Dubois, P., & Jérôme, R. (2000) · Macromolecules · doi:10.1021/ma991045r · Cited by 144 · see citing works
Multinuclear alkylaluminium macrocyclic Schiff base complexes: influence of procatalyst structure on the ring opening polymerisation of ε-caprolactone
Arbaoui, A., Redshaw, C., & Hughes, D. L. (2008) · Chemical Communications · doi:10.1039/b810417d · Cited by 122 · see citing works
Group 4 complexes of amine bis(phenolate)s and their application for the ring opening polymerisation of cyclic esters
Chmura, A. J., Davidson, M. G., Jones, M. D., Lunn, M. D., & Mahon, M. F. (2006) · Dalton Trans. · doi:10.1039/b513345a · Cited by 108 · see citing works

Flagged first, then by citations

Sorted by citations

Catalysis as an Enabling Science for Sustainable Polymers
Zhang, X., Fevre, M., Jones, G. O., & Waymouth, R. M. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00329 · Cited by 936 · see citing works
Chemically recyclable polymers: a circular economy approach to sustainability
Hong, M., & Chen, E. Y.-X. (2017) · Green Chemistry · doi:10.1039/c7gc01496a · Cited by 876 · see citing works
Degradation mechanisms of polycaprolactone in the context of chemistry, geometry and environment
Bartnikowski, M., Dargaville, T. R., Ivanovski, S., & Hutmacher, D. W. (2019) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2019.05.004 · Cited by 769 · see citing works
Ring-opening copolymerization (ROCOP): synthesis and properties of polyesters and polycarbonates
Paul, S., Zhu, Y., Romain, C., Brooks, R., Saini, P. K., & Williams, C. K. (2015) · Chemical Communications · doi:10.1039/c4cc10113h · Cited by 593 · see citing works
Advances in functionalized polymer coatings on biodegradable magnesium alloys–A review
Li, L.-Y., Cui, L.-Y., Zeng, R.-C., Li, S.-Q., Chen, X.-B., Zheng, Y., & Kannan, M. B. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.08.030 · Cited by 466 · see citing works
Super tough poly(lactic acid) blends: a comprehensive review
Zhao, X., Hu, H., Wang, X., Yu, X., Zhou, W., & Peng, S. (2020) · RSC Advances · doi:10.1039/d0ra01801e · Cited by 465 · see citing works
Aliphatic polyester polymer stars: Synthesis, properties and applications in biomedicine and nanotechnology
Cameron, D. J. A., & Shaver, M. P. (2011) · Chem. Soc. Rev. · doi:10.1039/c0cs00091d · Cited by 421 · see citing works
Depolymerization within a Circular Plastics System
Clark, R. A., & Shaver, M. P. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00739 · Cited by 408 · see citing works
Aliphatic Polyester Block Polymer Design
Schneiderman, D. K., & Hillmyer, M. A. (2016) · Macromolecules · doi:10.1021/acs.macromol.6b00211 · Cited by 290 · see citing works
Urea Anions: Simple, Fast, and Selective Catalysts for Ring-Opening Polymerizations
Lin, B., & Waymouth, R. M. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.6b11864 · Cited by 278 · see citing works
Chemoselective Polymerizations from Mixtures of Epoxide, Lactone, Anhydride, and Carbon Dioxide
Romain, C., Zhu, Y., Dingwall, P., Paul, S., Rzepa, H. S., Buchard, A., & Williams, C. K. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.5b13070 · Cited by 258 · see citing works
Chemistry, chances and limitations of the radical ring-opening polymerization of cyclic ketene acetals for the synthesis of degradable polyesters
Agarwal, S. (2010) · Polymer Chemistry · doi:10.1039/c0py00040j · Cited by 263 · see citing works
Catalytic Hydroxylation of Polyethylenes
Bunescu, A., Lee, S., Li, Q., & Hartwig, J. F. (2017) · ACS Central Science · doi:10.1021/acscentsci.7b00255 · Cited by 252 · see citing works
Untitled work
Fernández, J., Etxeberria, A., & Sarasua, J.-R. (2012) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2012.01.003 · Cited by 217 · see citing works
Effect of Molecular Weight on the Crystallization and Melt Memory of Poly(ε-caprolactone) (PCL)
Fernández-Tena, A., Pérez-Camargo, R. A., Coulembier, O., Sangroniz, L., Aranburu, N., Guerrica-Echevarria, G., Liu, G., Wang, D., Cavallo, D., & Müller, A. J. (2023) · Macromolecules · doi:10.1021/acs.macromol.3c00234 · Cited by 200 · see citing works
Ring-Opening Polymerization of rac-Lactide by Bis(phenolate)amine-Supported Samarium Borohydride Complexes: An Experimental and DFT Study
Dyer, H. E., Huijser, S., Susperregui, N., Bonnet, F., Schwarz, A. D., Duchateau, R., Maron, L., & Mountford, P. (2010) · Organometallics · doi:10.1021/om100513j · Cited by 158 · see citing works
ω-Pentandecalactone Polymerization and ω-Pentadecalactone/ε-Caprolactone Copolymerization Reactions Using Organic Catalysts
Bouyahyi, M., Pepels, M. P. F., Heise, A., & Duchateau, R. (2012) · Macromolecules · doi:10.1021/ma3001675 · Cited by 157 · see citing works
Polycaprolactone: Synthesis, Properties, and Applications
Guarino, V., Gentile, G., Sorrentino, L., & Ambrosio, L. (2017) · Encyclopedia of Polymer Science and Technology · doi:10.1002/0471440264.pst658 · Cited by 163 · see citing works
Poly(glycerol sebacate urethane)–cellulose nanocomposites with water-active shape-memory effects
Wu, T., Frydrych, M., O’Kelly, K., & Chen, B. (2014) · Biomacromolecules · doi:10.1021/bm500507z · Cited by 126 · see citing works
Renewable Polymers from Itaconic Acid by Polycondensation and Ring-Opening-Metathesis Polymerization
Winkler, M., Lacerda, T. M., Mack, F., & Meier, M. A. R. (2015) · Macromolecules · doi:10.1021/acs.macromol.5b00052 · Cited by 121 · see citing works
Fabricating alginate/poly (caprolactone) nanofibers with enhanced bio-mechanical properties via cellulose nanocrystal incorporation
Rashtchian, M., Hivechi, A., Bahrami, S. H., Milan, P. B., & Simorgh, S. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.115873 · Cited by 112 · see citing works
Synthesis of biodegradable polymers: A review on the use of schiff-base metal complexes as catalysts for the ring opening polymerization (ROP) of cyclic esters
Santoro, O., Zhang, X., & Redshaw, C. (2020) · Catalysts · doi:10.3390/catal10070800 · Cited by 111 · see citing works
Next Generation of Zinc Bisguanidine Polymerization Catalysts towards Highly Crystalline, Biodegradable Polyesters
Hermann, A., Hill, S., Metz, A., Heck, J., Hoffmann, A., Hartmann, L., & Herres‐Pawlis, S. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202008473 · Cited by 109 · see citing works
Random introduction of degradable linkages into functional vinyl polymers by radical ring-opening polymerization, tailored for soft tissue engineering
Undin, J., Illanes, T., Finne-Wistrand, A., & Albertsson, A.-C. (2012) · Polymer Chemistry · doi:10.1039/c2py20034a · Cited by 97 · see citing works
Dinuclear Zinc–N-Heterocyclic Carbene Complexes for Either the Controlled Ring-Opening Polymerization of Lactide or the Controlled Degradation of Polylactide Under Mild Conditions
Fliedel, C., Vila‐Viçosa, D., Calhorda, M. J., Dagorne, S., & Avilés, T. (2014) · ChemCatChem · doi:10.1002/cctc.201301015 · Cited by 95 · see citing works
Interplay between Crystallization and Entanglements in the Amorphous Phase of the Crystal-Fixed Polymer Poly(ϵ-caprolactone)
Kurz, R., Schulz, M., Scheliga, F., Men, Y., Seidlitz, A., Thurn-Albrecht, T., & Saalwächter, K. (2018) · Macromolecules · doi:10.1021/acs.macromol.8b00809 · Cited by 86 · see citing works
Phosphazene-catalyzed ring-opening polymerization of ε -caprolactone: influence of solvents and initiators
Alamri, H., Zhao, J., Pahovnik, D., & Hadjichristidis, N. (2014) · Polym. Chem. · doi:10.1039/c4py00493k · Cited by 89 · see citing works
Sequential polymerization of ethylene oxide, ε-caprolactone and <scp>l</scp> -lactide: a one-pot metal-free route to tri- and pentablock terpolymers
Zhao, J., Pahovnik, D., Gnanou, Y., & Hadjichristidis, N. (2014) · Polym. Chem. · doi:10.1039/c4py00429a · Cited by 79 · see citing works
Redox Control of Aluminum Ring-Opening Polymerization: A Combined Experimental and DFT Investigation
Wei, J., Riffel, M. N., & Diaconescu, P. L. (2017) · Macromolecules · doi:10.1021/acs.macromol.6b02402 · Cited by 76 · see citing works
Block and random copolymerization of ε‐caprolactone, L‐, and rac‐lactide using titanium complex derived from aminodiol ligand
Dakshinamoorthy, D., & Peruch, F. (2012) · Journal of Polymer Science Part A: Polymer Chemistry · doi:10.1002/pola.25983 · Cited by 77 · see citing works
Non-toxic catalysts for ring-opening polymerizations of biodegradable polymers at room temperature for biohybrid materials
Hege, C. S., & Schiller, S. M. (2014) · Green Chem. · doi:10.1039/c3gc42044b · Cited by 77 · see citing works
Synthesis of High Molecular Weight Polyesters via In Vacuo Dehydrogenation Polymerization of Diols
Hunsicker, D. M., Dauphinais, B. C., Mc Ilrath, S. P., & Robertson, N. J. (2012) · Macromolecular Rapid Communications · doi:10.1002/marc.201100653 · Cited by 63 · see citing works
Degradable polymers from ring-opening polymerization of α-angelica lactone, a five-membered unsaturated lactone
Chen, T., Qin, Z., Qi, Y., Deng, T., Ge, X., Wang, J., & Hou, X. (2011) · Polymer Chemistry · doi:10.1039/c1py00067e · Cited by 61 · see citing works
Synthesis of Poly(l-lactide-co-ε-caprolactone) Copolymer: Structure, Toughness, and Elasticity
Zhang, M., Chang, Z., Wang, X., & Li, Q. (2021) · Polymers · doi:10.3390/polym13081270 · Cited by 59 · see citing works
“Poly(lactic acid) (PLA) and poly(ε-caprolactone) (PCL) polyester materials have been extensively studied [7,8].”
Background
New Mechanism for the Ring-Opening Polymerization of Lactones? Uranyl Aryloxide-Induced Intermolecular Catalysis
Walshe, A., Fang, J., Maron, L., & Baker, R. J. (2013) · Inorganic Chemistry · doi:10.1021/ic401275e · Cited by 50 · see citing works
In Situ Versus Isolated Zinc Catalysts in the Selective Synthesis of Homo and Multi-block Polyesters
Gruszka, W., Walker, L. C., Shaver, M. P., & Garden, J. A. (2020) · Macromolecules · doi:10.1021/acs.macromol.0c00277 · Cited by 49 · see citing works
Group iv complexes containing the benzotriazole phenoxide ligand as catalysts for the ring-opening polymerization of lactides, epoxides and as precatalysts for the polymerization of ethylene
Pappuru, S., Chokkapu, E. R., Chakraborty, D., & Ramkumar, V. (2013) · Dalton Transactions · doi:10.1039/c3dt52065j · Cited by 47 · see citing works
Low valent Al(<scp>ii</scp>)–Al(<scp>ii</scp>) catalysts as highly active ε-caprolactone polymerization catalysts: indication of metal cooperativity through DFT studies
Kazarina, O. V., Gourlaouen, C., Karmazin, L., Morozov, A. G., Fedushkin, I. L., & Dagorne, S. (2018) · Dalton Transactions · doi:10.1039/c8dt02614a · Cited by 45 · see citing works
Self-assembled dual-drug loaded core-shell nanoparticles based on metal-free fully alternating polyester for cancer theranostics
Gupta, P. K., Pappuru, S., Gupta, S., Patra, B., Chakraborty, D., & Verma, R. S. (2019) · Materials Science and Engineering: C · doi:10.1016/j.msec.2019.03.041 · Cited by 44 · see citing works
Synthesis, self‐assembly, drug‐release behavior, and cytotoxicity of triblock and pentablock copolymers composed of poly(ε‐caprolactone), poly( <scp>L</scp> ‐lactide), and poly(ethylene glycol)
Sun, L., Shen, L., Zhu, M., Dong, C., & Wei, Y. (2010) · Journal of Polymer Science Part A: Polymer Chemistry · doi:10.1002/pola.24255 · Cited by 40 · see citing works
Cellulose nanocrystal effect on crystallization kinetics and biological properties of electrospun polycaprolactone
Hivechi, A., Bahrami, S. H., Siegel, R. A., Siehr, A., Sahoo, A., Milan, P. B., Joghataei, M. T., Amoupour, M., & Simorgh, S. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111855 · Cited by 38 · see citing works
Ring-opening polymerization and copolymerization of cyclic esters catalyzed by amidinate aluminum complexes
Osorio Meléndez, D., Castro‐Osma, J. A., Lara‐Sánchez, A., Rojas, R. S., & Otero, A. (2017) · Journal of Polymer Science Part A: Polymer Chemistry · doi:10.1002/pola.28629 · Cited by 38 · see citing works
The Role of Alkoxide Initiator, Spin State, and Oxidation State in Ring-Opening Polymerization of ε-Caprolactone Catalyzed by Iron Bis(imino)pyridine Complexes
Ortuño, M. A., Dereli, B., Chiaie, K. R. D., Biernesser, A. B., Qi, M., Byers, J. A., & Cramer, C. J. (2018) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.7b02964 · Cited by 35 · see citing works
Theoretical Studies on Aluminum Trialkoxide-Initiated Lactone Ring-Opening Polymerizations: Roles of Alkoxide Substituent and Monomer Ring Structure
Jitonnom, J., Molloy, R., Punyodom, W., & Meelua, W. (2016) · Computational and Theoretical Chemistry · doi:10.1016/j.comptc.2016.10.009 · Cited by 33 · see citing works
Fabrication and characterization of polycaprolactone-based green materials for drug delivery
Kurakula, M., Rao, G. S. N. K., & Yadav, K. S. (2021) · Applications of Advanced Green Materials · doi:10.1016/b978-0-12-820484-9.00016-7 · Cited by 34 · see citing works
A new class of MPV type reduction in group 4 alkoxide complexes of salicylaldiminato ligands: Efficient catalysts for the ROP of lactides, epoxides and polymerization of ethylene
Chakraborty, D., Mandal, D., Ramkumar, V., Subramanian, V., & Vijaya Sundar, J. (2015) · Polymer · doi:10.1016/j.polymer.2014.10.074 · Cited by 33 · see citing works
Synthetic biodegradable medical polyesters
Cama, G., Mogosanu, D. E., Houben, A., & Dubruel, P. (2017) · Science and Principles of Biodegradable and Bioresorbable Medical Polymers · doi:10.1016/b978-0-08-100372-5.00003-9 · Cited by 33 · see citing works
Synthesis of high-molecular-weight poly (ε-caprolactone) via heterogeneous zinc-cobalt (III) double metal cyanide complex
Liu, Z.-H., Li, Y., Zhang, C.-J., Zhang, Y.-Y., Cao, X.-H., & Zhang, X.-H. (2020) · Giant · doi:10.1016/j.giant.2020.100030 · Cited by 34 · see citing works
Bis(phosphinimino)methanide borohydride complexes of the rare-earth elements as initiators for the ring-opening polymerization of trimethylene carbonate: Combined experimental and computational investigations
Guillaume, S. M., Brignou, P., Susperregui, N., Maron, L., Kuzdrowska, M., Kratsch, J., & Roesky, P. W. (2012) · Polym. Chem. · doi:10.1039/c1py00487e · Cited by 32 · see citing works
Metal-free semi-aromatic polyester as nanodrug carrier: A novel tumor targeting drug delivery vehicle for potential clinical application
Gupta, P. K., Tripathi, S. K., Pappuru, S., Chabattula, S. C., Govarthanan, K., Gupta, S., Biswal, B. K., Chakraborty, D., & Verma, R. S. (2020) · Materials Science and Engineering: C · doi:10.1016/j.msec.2019.110285 · Cited by 29 · see citing works
Dimethylaluminium Iminophosphoranylenamides and Iminophosphoranylanilides: Synthesis, Characterisation, and Their Controlled Ring-Opening Polymerisation of ε-Caprolactone
Ma, W.-A., Wang, L., & Wang, Z.-X. (2011) · Dalton Transactions · doi:10.1039/c0dt01713b · Cited by 29 · see citing works
Technical development and application of supercritical CO2 foaming technology in PCL foam production
Zhou, Y., Tian, Y., & Zhang, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-57545-6 · Cited by 28 · see citing works
Living/controlled ring-opening (co)polymerization of lactones by Al-based catalysts with different sidearms
Zhao, W., Wang, Q., Cui, Y., He, J., & Zhang, Y. (2019) · Dalton Transactions · doi:10.1039/c8dt03941k · Cited by 29 · see citing works
Selective Transesterification to Control Copolymer Microstructure in the Ring-Opening Copolymerization of Lactide and ε-Caprolactone by Lanthanum Complexes
Beament, B., Britton, D., Malcomson, T., Akien, G. R., Halcovitch, N. R., Coogan, M. P., & Platel, R. H. (2024) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.3c03120 · Cited by 27 · see citing works
Improved mechanical properties of biodegradable polycaprolactone nanocomposites prepared using cellulose nanocrystals
Jeon, H., Kim, M.-S., Park, S. B., Kim, S., Lee, M., Park, S.-A., Hwang, S. Y., Koo, J. M., Oh, D. X., & Park, J. (2023) · Cellulose · doi:10.1007/s10570-023-05615-9 · Cited by 27 · see citing works
Theoretical Study on the Ring-Opening Polymerization of ε-Caprolactone by [YMeX(THF)5]+ with X = BH4, NMe2
Susperregui, N., Kramer, M. U., Okuda, J., & Maron, L. (2011) · Organometallics · doi:10.1021/om100606p · Cited by 22 · see citing works
Vanadium( <scp>v</scp> ) phenolate complexes for ring opening homo- and co-polymerisation of ε-caprolactone, <scp>l</scp> -lactide and rac-lactide
Ge, F., Dan, Y., Al-Khafaji, Y., Prior, T. J., Jiang, L., Elsegood, M. R. J., & Redshaw, C. (2016) · RSC Advances · doi:10.1039/c5ra24816g · Cited by 22 · see citing works
Turning on ROP activity in a bimetallic Co/Zn complex supported by a [2+2] Schiff-base macrocycle
Wang, K., Prior, T. J., & Redshaw, C. (2019) · Chemical Communications · doi:10.1039/c9cc04494a · Cited by 20 · see citing works
Degradable elastomeric block copolymers based on polycaprolactone by free-radical chemistry
Grabe, N., Zhang, Y., & Agarwal, S. (2011) · Macromolecular Chemistry and Physics · doi:10.1002/macp.201100031 · Cited by 20 · see citing works
Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering
Fazel Anvari-Yazdi, A., Badea, I., & Chen, X. (2025) · Gels · doi:10.3390/gels11060441 · Cited by 20 · see citing works
A DFT study on ring-opening polymerization of ε-caprolactone initiated by Mg and Al complexes
Li, P., Xi, Y., Li, L., Li, H., Sun, W.-H., & Lei, M. (2018) · Inorganica Chimica Acta · doi:10.1016/j.ica.2018.02.033 · Cited by 15 · see citing works
Enhancing the anti-cancer therapeutic efficacy by optimizing molecular weight of metal-free fully alternating semi-aromatic polyester as nano-drug carriers
Gupta, P. K., Gupta, S., Pappuru, S., Chabattula, S. C., Chakraborty, D., & Verma, R. S. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2019.02.022 · Cited by 12 · see citing works
Monitoring of Morphology and Properties During Preparation of PCL/PLA Microfibrillar Composites With Organophilic Montmorillonite
Slouf, M., Ujcic, A., Nevoralova, M., Vackova, T., Fambri, L., & Kelnar, I. (2020) · Frontiers in Materials · doi:10.3389/fmats.2020.00188 · Cited by 10 · see citing works
Soft, Formstable (Co)Polyester Blend Elastomers
Neffe, A., Izraylit, V., Hommes-Schattmann, P., & Lendlein, A. (2021) · Nanomaterials · doi:10.3390/nano11061472 · Cited by 9 · see citing works
Molecular engineering of nanocellulose-poly(lactic acid) bio-nanocomposite interface by reactive surface grafting from copolymerization
Ye, G., Yong, Q., Hu, L., Rosqvist, E., Peltonen, J., Hu, Y., Xu, W., & Xu, C. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.141371 · Cited by 9 · see citing works
High level potential energy surface and mechanism of Al(CH 3 ) 2 OCH 3 -promoted lactone polymerization: initiation and propagation
Vogt-Geisse, S., Mata, R. A., & Toro-Labbé, A. (2017) · Physical Chemistry Chemical Physics · doi:10.1039/c7cp00809k · Cited by 5 · see citing works
Investigating the Phase-Morphology of PLLA-PCL Multiblock Copolymer / PDLA Blends Cross-linked Using Stereocomplexation
Izraylit, V., Gould, O. E. C., Kratz, K., & Lendlein, A. (2020) · MRS Advances · doi:10.1557/adv.2019.465 · Cited by 4 · see citing works

Authors: Labet, M., & Thielemans, W.
Affiliations: University of Nottingham (GB)
Corresponding author: Thielemans, Wim
ORCID: Labet, Marianne
Thielemans, Wim
Venue: Chemical Society Reviews
Publisher: Royal Society of Chemistry (RSC)
Published: 2009
Volume: 38
Issue: 12
Pages: 3484
ISSN: 0306-0012 (ISSN-L)
1460-4744
DOI: 10.1039/b820162p
OpenAlex: W2151585742
Cited by: 1,673
References: 4
Citations by year: 2026: 77 · 2025: 144 · 2024: 132 · 2023: 138 · 2022: 153 · 2021: 148 · 2020: 136 · 2019: 99 · 2018: 116 · 2017: 106 · 2016: 91 · 2015: 98 · 2014: 70 · 2013: 58 · 2012: 50
FWCI: 1.75
Type: journal article
Language: en
Open access: closed
Locations: Chemical Society Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
Physical Sciences › Chemical Engineering › Process Chemistry and Technology › Carbon dioxide utilization in catalysis
Physical Sciences › Materials Science › Polymers and Plastics › Polymer crystallization and properties
Keywords: polycaprolactone, ε-caprolactone, ring-opening polymerization, polycondensation, 6-hydroxyhexanoic acid, polymer synthesis, catalytic systems, enzymatic catalysts, metal catalysts, organic catalysts, initiators, reaction mechanism, biodegradable polymers
MeSH terms: Polyesters, Stereoisomerism, Molecular Structure, Tissue Scaffolds

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Synthesis of polycaprolactone: A review

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Record

About these checks