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Cofactor Specificity of Glucose-6-Phosphate Dehydrogenase Isozymes in Pseudomonas putida Reveals a General Principle Underlying Glycolytic Strategies in Bacteria
Abstract
Protein families have likely arisen during evolution by gene duplication and divergence followed by neofunctionalization. While this phenomenon is well documented for catabolic activities (typical of environmental bacteria that colonize highly polluted niches), the coexistence of multiple isozymes in central carbon catabolism remains relatively unexplored.
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Pseudomonas putida KT2440 runs a cyclic glycolytic metabolism (EDEMP cycle) composed of Entner-Doudoroff, Embden-Meyerhof-Parnas, and pentose phosphate pathways.
“Pseudomonas putida KT2440 runs a cyclic glycolytic metabolism, composed by catabolic and anabolic activities of the Entner–Doudoroff pathway and the Embden–Meyerhof–Parnas (EMP) pathway (in a gluconeogenic fashion), together with the pentose phosphate (PP) pathway (Nikel et al., 2015b; Volke et al., 2021).”
From Role of the CrcB transporter of Pseudomonas putida in the multi‐level stress response elicited by mineral fluoride (2022) · cites this paper as Volke et al., 2021
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Christodoulou, D., Link, H., Fuhrer, T., Kochanowski, K., Gerosa, L., & Sauer, U. (2018) · Cell Systems · doi:10.1016/j.cels.2018.04.009 · Cited by 214
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Calero, P., Gurdo, N., & Nikel, P. I. (2022) · Environmental Microbiology · doi:10.1111/1462-2920.16110 · Cited by 56
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Metadata
- Authors
- Volke, D. C., Olavarría, K., & Nikel, P. I.
- Affiliations
- The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark
- Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
- ORCID
- Nikel, Pablo Iván
- Venue
- mSystems
- Publisher
- American Society for Microbiology
- Published
- 2021-04-27
- Volume
- 6
- Issue
- 2
- ISSN
- 2379-5077
- PMC
- PMC8546961
- Cited by
- 42
- References
- 1
- Language
- en
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo (2013/24087-8)
- H2020 Excellent Science (814418)
- Ministry of Science, Innovation and Higher Education | Danish Agency for Science and Higher Education (8021-00039B)
- Novo Nordisk Fonden (NNF20CC0035580, NNF18OC0034818)
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