The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Probiotic Bifidobacterium lactis V9 Regulates the Secretion of Sex Hormones in Polycystic Ovary Syndrome Patients through the Gut-Brain Axis
Open accessAbstract
Polycystic ovary syndrome (PCOS) is a common metabolic disorder among women of reproductive age worldwide. Through a two-phase clinical experiment, we first revealed an imbalance in the intestinal microbiome of PCOS patients. By binning and annotating shotgun metagenomic sequences into metagenomic species (MGS), 61 MGSs were identified as potential PCOS-related microbial biomarkers. In the second stage, we monitored the impact of the probiotic Bifidobacterium lactis V9 on the intestinal microbiota, metabolic parameters, gut-brain mediators, and sex hormones of PCOS patients. Notably, we observed that the PCOS-related clinical indices and the intestinal microbiotas of the participating patients exhibited an inconsistent response to the intake of the B. lactis V9 probiotic. Therefore, effective host gut colonization of the probiotic was crucial for its ability to function as a probiotic. Finally, we propose a potential mechanism by which B. lactis V9 regulates the levels of sex hormones by manipulating the intestinal microbiome in PCOS patients.
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Cited by
He, F.-F., & Li, Y.-M. (2020) · Journal of Ovarian Research · doi:10.1186/s13048-020-00670-3 · Cited by 289
Metabolic Syndrome and PCOS: Pathogenesis and the Role of Metabolites
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Gut microbiota alterations reveal potential gut–brain axis changes in polycystic ovary syndrome
Liang, Z., Di, N., Li, L., & Yang, D. (2021) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01481-5 · Cited by 109
Metadata
- Authors
- Zhang, J., Sun, Z., Jiang, S., Bai, X., Ma, C., Peng, Q., Chen, K., Chang, H., Fang, T., & Zhang, H.
- Venue
- mSystems
- Publisher
- American Society for Microbiology
- Published
- 2019-04-30
- Volume
- 4
- Issue
- 2
- ISSN
- 2379-5077 (ISSN-L)
- OpenAlex
- W2936021613
- Cited by
- 282
- References
- 56
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhang, J., Sun, Z., Jiang, S., Bai, X., Ma, C., Peng, Q., Chen, K., Chang, H., Fang, T., & Zhang, H. (2019). Probiotic Bifidobacterium lactis V9 Regulates the Secretion of Sex Hormones in Polycystic Ovary Syndrome Patients through the Gut-Brain Axis. mSystems. https://doi.org/10.1128/msystems.00017-19
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