Cited by 7,070Gut microbiota and healthMicrobial Metabolites in Food BiotechnologyGastrointestinal motility and disorders

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

Open access
Koh, Ara, De Vadder, Filipe, Kovatcheva-Datchary, Petia, Bäckhed, Fredrik·2016·Cell

Abstract

A compelling set of links between the composition of the gut microbiota, the host diet, and host physiology has emerged. Do these links reflect cause-and-effect relationships, and what might be their mechanistic basis? A growing body of work implicates microbially produced metabolites as crucial executors of diet-based microbial influence on the host. Here, we will review data supporting the diverse functional roles carried out by a major class of bacterial metabolites, the short-chain fatty acids (SCFAs). SCFAs can directly activate G-coupled-receptors, inhibit histone deacetylases, and serve as energy substrates. They thus affect various physiological processes and may contribute to health and disease.

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Crossref · 10.1016/j.cell.2016.05.041

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Authors
Koh, A., De Vadder, F., Kovatcheva-Datchary, P., & Bäckhed, F.
Affiliations
  • University of Gothenburg (SE)
  • University of Copenhagen (DK)
Corresponding author
Bäckhed, Fredrik
Venue
Cell
Publisher
Elsevier BV
Published
2016-06
Volume
165
Issue
6
Pages
1332-1345
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2409656339
Cited by
7,070
References
101
Citations by year
2026: 1245 · 2025: 980 · 2024: 886 · 2023: 826 · 2022: 870 · 2021: 827 · 2020: 625 · 2019: 447 · 2018: 219 · 2017: 121 · 2016: 18 · 2012: 1
FWCI
24.01
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
Funders
  • Hjärt-Lungfonden
  • Knut och Alice Wallenbergs Stiftelse
  • Novo Nordisk Fonden (NNF13OC0008163)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
short-chain fatty acids, gut microbiota, dietary fiber, host physiology, microbial metabolites, histone deacetylase inhibition, energy metabolism, host-microbe interactions, diet and health
MeSH terms
Gastrointestinal Microbiome, Animals, Dietary Fiber, Fatty Acids, Volatile, Histones, Humans, Intestines, Signal Transduction

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