From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
Open accessAbstract
A compelling set of links between the composition of the gut microbiota, the host diet, and host physiology has emerged. Do these links reflect cause-and-effect relationships, and what might be their mechanistic basis? A growing body of work implicates microbially produced metabolites as crucial executors of diet-based microbial influence on the host. Here, we will review data supporting the diverse functional roles carried out by a major class of bacterial metabolites, the short-chain fatty acids (SCFAs). SCFAs can directly activate G-coupled-receptors, inhibit histone deacetylases, and serve as energy substrates. They thus affect various physiological processes and may contribute to health and disease.
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- Authors
- Koh, A., De Vadder, F., Kovatcheva-Datchary, P., & Bäckhed, F.
- Affiliations
- University of Gothenburg (SE)
- University of Copenhagen (DK)
- Corresponding author
- Bäckhed, Fredrik
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 165
- Issue
- 6
- Pages
- 1332-1345
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2409656339
- Cited by
- 7,070
- References
- 101
- Citations by year
- 2026: 1245 · 2025: 980 · 2024: 886 · 2023: 826 · 2022: 870 · 2021: 827 · 2020: 625 · 2019: 447 · 2018: 219 · 2017: 121 · 2016: 18 · 2012: 1
- FWCI
- 24.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Funders
- Hjärt-Lungfonden
- Knut och Alice Wallenbergs Stiftelse
- Novo Nordisk Fonden (NNF13OC0008163)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- short-chain fatty acids, gut microbiota, dietary fiber, host physiology, microbial metabolites, histone deacetylase inhibition, energy metabolism, host-microbe interactions, diet and health
- MeSH terms
- Gastrointestinal Microbiome, Animals, Dietary Fiber, Fatty Acids, Volatile, Histones, Humans, Intestines, Signal Transduction
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