Arginine-vasopressin receptor gene (AVPR1A, AVPR1B) polymorphisms and their relation to personality traits
Abstract
The present study aimed to assess the main effects ofAVPRIA (rs11174811, RSI) and AVPRIB (rs28632197, rs33911258) gene polymorphisms, as well as haplotypic, GxE and GxG effects on personality trait variation in 1018 healthy individuals, considering gender and ethnicity confounding. Haplotype analysis revealed an association ofAVPRIA C*S- and C*L-haplotype (rs11174811 and RS1, respectively) and increased (PFDR= 0.016) or decreased (PFDR = 0.031) Extraversion (EPI) in Bashkirs, respectively. The association of AVPR1B G*A-haplotype (rs28632197 and rs33911258, respectively) and decreased Self-transcendence (TCI-125) (P(FDR) = 0.040) was demonstrated in the total sample and in Udmurts. GxE analysis revealed that the birth season modulated the involvement of the AVPR1A (rs11174811) gene marker in the variation of Persistence (TCI-125) in the total sample (P(FDR) = 0.012). The modulating effect of several environmental factors (ethnicity and birth season) on the association of AVPR1A and AVPR1B gene polymorphisms and personality traits was established.
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Environmental factors play a modulating role in establishing specific patterns of behavior, including ASB-related ones.
“It is known that environmental factors play a modulating role in establishing specific patterns of behavior (Kazantseva et al., 2014), including ASB-related ones.”
From Using polygenic scores to assess liability to antisocial behavior (2025) · cites this paper as Kazantseva et al., 2014
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Barrett, C. E., Keebaugh, A. C., Ahern, T. H., Bass, C. E., Terwilliger, E. F., & Young, L. J. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.01.005 · Cited by 100 · see citing works
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Using polygenic scores to assess liability to antisocial behavior
Kazantseva, A. V., Yakovleva, D. V., Davydova, Y. D., & Khusnutdinova, E. K. (2025) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vjgb-25-91
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- Authors
- Kazantseva, A. V., Kutlumbetova, Y. Y., Malykh, S. B., Lobaskova, M. M., & Khusnutdinova, E. K.
- Affiliations
- Russian Academy of Sciences (RU)
- Bashkir State University (RU)
- Russian Academy of Education (RU)
- Udmurt State University (RU)
- Corresponding author
- Kazantseva, A. V.
- Venue
- Russian Journal of Genetics
- Publisher
- Pleiades Publishing Ltd
- Published
- 2014-03
- Volume
- 50
- Issue
- 3
- Pages
- 298-307
- ISSN
- 1022-7954 (ISSN-L)
- 1608-3369
- OpenAlex
- W2012981893
- Cited by
- 11
- References
- 1
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2020: 2 · 2019: 1 · 2015: 1
- FWCI
- 0.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Russian Journal of Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Clinical Psychology › Personality Traits and Psychology
- Keywords
- arginine vasopressin receptor, AVPR1A, AVPR1B, genetic polymorphism, personality traits, extraversion, self-transcendence, persistence, haplotype analysis, gene-environment interaction, season of birth, Bashkirs, Udmurts
- MeSH terms
- Female, Haplotypes, Humans, Male, Personality, Sex Factors, Receptors, Vasopressin, Polymorphism, Single Nucleotide, Young Adult, Gene-Environment Interaction
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