Variation in vasopressin receptor (Avpr1a) expression creates diversity in behaviors related to monogamy in prairie voles
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Polymorphisms in noncoding regions of the vasopressin 1a receptor gene (Avpr1a) are associated with a variety of socioemotional characteristics in humans, chimpanzees, and voles, and may impact behavior through a site-specific variation in gene expression. The socially monogamous prairie vole offers a unique opportunity to study such neurobiological control of individual differences in complex behavior. Vasopressin 1a receptor (V1aR) signaling is necessary for the formation of the pair bond in males, and prairie voles exhibit greater V1aR binding in the reward-processing ventral pallidum than do asocial voles of the same genus. Diversity in social behavior within prairie voles has been correlated to natural variation in neuropeptide receptor expression in specific brain regions. Here we use RNA interference to examine the causal relationship between intraspecific variation in V1aR and behavioral outcomes, by approximating the degree of naturalistic variation in V1aR expression. Juvenile male prairie voles were injected with viral vectors expressing shRNA sequences targeting Avpr1a mRNA into the ventral pallidum. Down-regulation of pallidal V1aR density resulted in a significant impairment in the preference for a mated female partner and a reduction in anxiety-like behavior in adulthood. No effect on alloparenting was detected. These data demonstrate that within-species naturalistic-like variation in V1aR expression has a profound effect on individual differences in social attachment and emotionality. RNA interference may prove to be a useful technique to unite the fields of behavioral ecology and neurogenetics to perform ethologically relevant studies of the control of individual variation and offer insight into the evolutionary mechanisms leading to behavioral diversity.
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Oxytocin, dopamine, and vasopressin regulate neural circuits responsible for generating bonds in animals and humans.
“Here, we provide an overview of the roles of oxytocin, dopamine, and vasopressin in regulating neural circuits responsible for generating bonds in animals and humans alike.”
From The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives (2023) · cites this paper as [17]
The Discussion (page unavailable) describes pair bonding as involving neuropeptide-mediated social cues and dopaminergic reward pathways, and reports that altering vasopressin V1a receptor expression impaired partner preference in male prairie voles. It does not establish the same bond-generating mechanism in humans or specifically demonstrate oxytocin’s role in that mechanism. (LLM, conf=0.85)
Experimental — accuracy not yet measuredPrairie voles show much higher AVPR1a expression in the ventral pallidum than meadow voles, and viral knockdown of AVPR1a in the VP of prairie voles impairs partner preference.
“Prairie voles show much higher AVPR1a expression in the ventral pallidum (VP) than meadow voles and viral knockdown of AVPR1a in the VP of prairie voles impairs partner preference [17,145].”
From The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives (2023) · cites this paper as [17]
Organizational plasticity of steroid hormone and neuropeptide systems across the SDMN is an important mechanism contributing to diversity in distributed network function and social behavior within and across species.
“It is further hypothesized that organizational plasticity of steroid hormone and neuropeptide systems across the SDMN is an important mechanism contributing to diversity in distributed network function and social behavior within and across species”
From Oxytocin receptors modulate a social salience neural network in male prairie voles (2017) · cites this paper as Barrett et al., 2013
V1aR signaling in the ventral pallidum and lateral septum promote partner preferences, while pair bond-induced aggression is mediated by V1aR in the lateral hypothalamus.
“V1aR signaling in the ventral pallidum and LS promote partner preferences (149), while pair bond-induced aggression is mediated by V1aR in the lateral hypothalamus (43,150).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [150]
Among rodents, there is pronounced interspecific variation in OTR and V1aR binding in the central nervous system that reflects differential social organization and mating strategies.
“Among rodents, there is pronounced interspecific variation in OTR and V1aR binding in the central nervous system that reflects differential social organization and mating strategies (Barrett et al., 2013; Beery et al., 2008; Insel and Shapiro, 1992; Mooney et al., 2015; Ophir et al., 2012; Young et al., 2011).”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Barrett et al., 2013
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- Authors
- Barrett, C. E., Keebaugh, A. C., Ahern, T. H., Bass, C. E., Terwilliger, E. F., & Young, L. J.
- Affiliations
- Emory National Primate Research Center (US)
- Emory University (US)
- Harvard University (US)
- Corresponding author
- Barrett, Catherine E.
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 63
- Issue
- 3
- Pages
- 518-526
- ISSN
- 0018-506X (ISSN-L)
- PMC
- PMC3602142
- OpenAlex
- W2146976480
- Cited by
- 100
- References
- 82
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 3 · 2023: 2 · 2022: 8 · 2021: 10 · 2020: 4 · 2019: 3 · 2018: 8 · 2017: 9 · 2016: 16 · 2015: 12 · 2014: 8 · 2013: 5
- FWCI
- 20.45
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation
- National Institutes of Health (P51OD011132)
- Yerkes National Primate Research Center, Emory University
- National Institute of Mental Health (K02MH064692, MH064692, R29MH056897, MH056897, R01MH056897)
- National Institute on Drug Abuse (K01DA024763)
- National Center for Research Resources (P51RR165)
- Office of Research Infrastructure Programs, National Institutes of Health
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- vasopressin 1a receptor, AVPR1A, Microtus ochrogaster, monogamy, pair bond, ventral pallidum, shRNA knockdown, anxiety-like behavior, social attachment, individual differences in behavior, alloparenting, neurogenetics, gene expression variation
- MeSH terms
- Animals, Anxiety, Basal Ganglia, Arvicolinae, Female, Genetic Vectors, Individuality, Male, Pair Bond, RNA, Messenger, Sexual Behavior, Animal, Vasopressins, Down-Regulation, Receptors, Vasopressin, RNA, Small Interfering
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