Exosome drug delivery through the blood–brain barrier: experimental approaches and potential applications
Abstract
This review discusses the current experimental data on targeted drug delivery through the blood–brain barrier (BBB). We focus on exosome drug delivery and examine the unique biological structure of exosomes, which allows them to pack, store, and deliver various molecules to the brain. Various approaches to modification and engineering of exosomes are reviewed with an analysis of experimental studies of exosome drug delivery through the BBB. The problems associated with potential clinical uses of exosomes and their possible solutions are discussed.
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The engineered exosomes could cross the multiple layers of the blood-brain-barrier and target cancer cells within the brain tissue.
“Importantly, the engineered exosomes could cross the multiple layers of the blood-brain-barrier (BBB) and target cancer cells within the brain tissue (40, 65–68).”
From Potential Therapeutic Effects of Exosomes Packed With a miR-21-Sponge Construct in a Rat Model of Glioblastoma (2019) · cites this paper as [66]
Cites
Johnsen, K. B., Gudbergsson, J. M., Skov, M. N., Pilgaard, L., Moos, T., & Duroux, M. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.04.005 · Cited by 704 · see citing works
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Monfared, H., Jahangard, Y., Nikkhah, M., Mirnajafi-Zadeh, J., & Mowla, S. J. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00782 · Cited by 123 · see citing works
- Authors
- Druzhkova, T. A., & Yakovlev, A. A.
- Affiliations
- Russian Academy of Sciences (RU)
- Corresponding author
- Yakovlev, A. A.
- Venue
- Neurochemical Journal
- Publisher
- Pleiades Publishing Ltd
- Published
- 2018-07
- Volume
- 12
- Issue
- 3
- Pages
- 195-204
- ISSN
- 1819-7124 (ISSN-L)
- 1819-7132
- OpenAlex
- W2889615651
- Cited by
- 33
- References
- 1
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 4 · 2019: 5
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Neurochemical Journal (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- exosomes, blood-brain barrier, targeted drug delivery, exosome engineering, exosome modification, brain drug delivery
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