A comprehensive overview of exosomes as drug delivery vehicles — Endogenous nanocarriers for targeted cancer therapy

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834 · see citing works

Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review

Maeda, H., Wu, J., Sawa, T., Matsumura, Y., & Hori, K. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00248-5 · Cited by 6,565 · see citing works

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

Skog, J., Würdinger, T., van Rijn, S., Meijer, D. H., Gainche, L., Curry, W. T., Carter, B. S., Krichevsky, A. M., & Breakefield, X. O. (2008) · Nature Cell Biology · doi:10.1038/ncb1800 · Cited by 5,001 · see citing works

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930 · see citing works

Membrane vesicles as conveyors of immune responses

Théry, C., Ostrowski, M., & Segura, É. (2009) · Nature reviews. Immunology · doi:10.1038/nri2567 · Cited by 3,869 · see citing works

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715 · see citing works

Strategies in the design of nanoparticles for therapeutic applications

Petros, R. A., & DeSimone, J. M. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd2591 · Cited by 3,651 · see citing works

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

Trajković, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., Schwille, P., Brügger, B., & Simons, M. (2008) · Science · doi:10.1126/science.1153124 · Cited by 3,639 · see citing works

B lymphocytes secrete antigen-presenting vesicles.

Raposo, G., Nijman, H. W., Stoorvogel, W., Liejendekker, R., Harding, C. V., Melief, C. J., & Geuze, H. J. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.3.1161 · Cited by 3,546 · see citing works

Extracellular vesicles: biology and emerging therapeutic opportunities

EL Andaloussi, S., Mäger, I., Breakefield, X. O., & Wood, M. J. A. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3978 · Cited by 3,254 · see citing works

Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)

Johnstone, R. M., Adam, M., Hammond, J. R., Orr, L., & Turbide, C. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48095-7 · Cited by 2,931 · see citing works

Rab27a and Rab27b control different steps of the exosome secretion pathway

Ostrowski, M., Carmo, N., Krumeich, S., Fanget, I., Raposo, G., Savina, A., Moita, C. F., Schauer, K., Hume, A. N., Freitas, R. P., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb2000 · Cited by 2,761 · see citing works

Gene transfer into mouse lyoma cells by electroporation in high electric fields.

Neumann, E., Schaefer-Ridder, M., Wang, Y., & HOFSCHNEIDER, P. H. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01257.x · Cited by 2,510 · see citing works

Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems

Tacar, O., Sriamornsak, P., & Dass, C. R. (2012) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2012.01567.x · Cited by 2,469 · see citing works

Standardization of sample collection, isolation and analysis methods in extracellular vesicle research

Witwer, K. W., Buzás, E. I., Bemis, L., Bora, A., Lässer, C., Lötvall, J. O., Hoen, E. N. M. N., Piper, M. G., Sivaraman, S., Skog, J., et al. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.20360 · Cited by 2,424 · see citing works

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

Lai, R. C., Arslan, F., Lee, M. M., Sze, N. S. K., Choo, A., Chen, T. S., Salto-Tellez, M., Timmers, L., Lee, C. N., El Oakley, R. M., et al. (2010) · Stem Cell Research · doi:10.1016/j.scr.2009.12.003 · Cited by 2,215 · see citing works

The nucleic acids

Chargaff, E., & Davidson, J. N. (1955) · Cited by 2,043 · see citing works

Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor

Pan, B., & Johnstone, R. M. (1983) · Cell · doi:10.1016/0092-8674(83)90040-5 · Cited by 2,042 · see citing works

Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

Vlassov, A. V., Magdaleno, S. M., Setterquist, R. A., & Conrad, R. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.03.017 · Cited by 1,936 · see citing works

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

Kosaka, N., Iguchi, H., Yoshioka, Y., Takeshita, F., Matsuki, Y., & Ochiya, T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.107821 · Cited by 1,934 · see citing works

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

Villarroya-Beltri, C., Gutiérrez-Vázquez, C., Sánchez-Cabo, F., Perez-Hernandez, D., Vázquez, J., Martín-Cófreces, N., Martínez-Herrera, D. J., Pascual-Montano, A., Mittelbrunn, M., & Sánchez-Madrid, F. (2013) · Nature Communications · doi:10.1038/ncomms3980 · Cited by 1,907 · see citing works

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

Baietti, M. F., Zhang, Z., Mortier, E., Melchior, A., Degeest, G., Geeraerts, A., Ivarsson, Y., Depoortere, F., Coomans, C., Vermeiren, E., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2502 · Cited by 1,899 · see citing works

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

Tian, Y., Li, S., Song, J., Ji, T., Zhu, M., Anderson, G. J., Wei, J., & Nie, G. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.083 · Cited by 1,809 · see citing works

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

Ohno, S.-I., Takanashi, M., Sudo, K., Ueda, S., Ishikawa, A., Matsuyama, N., Fujita, K., Mizutani, T., Ohgi, T., Ochiya, T., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2012.180 · Cited by 1,666 · see citing works

Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery

Ratajczak, J., Miękus, K., Kucia, M., Zhang, J., Reca, R., Dvořák, P., & Ratajczak, M. Z. (2006) · Leukemia · doi:10.1038/sj.leu.2404132 · Cited by 1,630 · see citing works

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

Sun, D., Zhuang, X., Xiang, X., Liu, Y., Zhang, S., Liu, C., Barnes, S., Grizzle, W. E., Miller, D., & Zhang, H. (2010) · Molecular Therapy · doi:10.1038/mt.2010.105 · Cited by 1,579 · see citing works

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

Raiborg, C., & Stenmark, H. (2009) · Nature · doi:10.1038/nature07961 · Cited by 1,408 · see citing works

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

Zhuang, X., Xiang, X., Grizzle, W., Sun, D., Zhang, S., Axtell, R. C., Ju, S., Mu, J., Zhang, L., Steinman, L., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2011.164 · Cited by 1,356 · see citing works

Exosomal-like vesicles are present in human blood plasma

Caby, M.-P., Lankar, D., Vincendeau-Scherrer, C., Raposo, G., & Bonnerot, C. (2005) · International Immunology · doi:10.1093/intimm/dxh267 · Cited by 1,348 · see citing works

Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial

Escudier, B. J., Dorval, T., Chaput, N., André, F., Caby, M.-P., Novault, S., Flament, C., Leboulaire, C., Borg, C., Amigorena, S., et al. (2005) · Journal of Translational Medicine · doi:10.1186/1479-5876-3-10 · Cited by 1,285 · see citing works

Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration

Zhang, Y., Liu, D., Chen, X., Li, J., Li, L., Bian, Z., Sun, F., Lu, J., Yin, Y., Cai, X. F., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.010 · Cited by 1,190 · see citing works

NCBI Reference Sequences (RefSeq): current status, new features and genome annotation policy

Pruitt, K. D., Tatusova, T., Brown, G. R., & Maglott, D. R. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr1079 · Cited by 1,149 · see citing works

A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer

Morse, M. A., Garst, J. L., Osada, T., Khan, S., Hobeika, A. C., Clay, T. M., Valente, N., Shreeniwas, R., Sutton, M. A., Delcayre, A. X., et al. (2005) · Journal of Translational Medicine · doi:10.1186/1479-5876-3-9 · Cited by 1,123 · see citing works

Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses

Bobrie, A., Colombo, M., Raposo, G., & Théry, C. (2011) · Traffic · doi:10.1111/j.1600-0854.2011.01225.x · Cited by 1,102 · see citing works

ExoCarta 2012: database of exosomal proteins, RNA and lipids

Mathivanan, S., Fahner, C. J., Reid, G. E., & Simpson, R. J. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr828 · Cited by 1,096 · see citing works

Exfoliation of membrane ecto-enzymes in the form of micro-vesicles

Trams, E. G., Lauter, C. J., Salem, N., & Heine, U. (1981) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(81)90512-5 · Cited by 1,094 · see citing works

Tissue-factor–bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation

Conde, I. D., Shrimpton, C. N., Thiagarajan, P., & López, J. A. (2005) · Blood · doi:10.1182/blood-2004-03-1095 · Cited by 1,030 · see citing works

Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors

Jang, S. C., Kim, O. Y., Yoon, C. M., Choi, D., Roh, T., Park, J., Nilsson, J. A., Lötvall, J. O., Kim, Y., & Gho, Y. S. (2013) · ACS Nano · doi:10.1021/nn402232g · Cited by 1,023 · see citing works

Modern methods for delivery of drugs across the blood–brain barrier

Chen, Y., & Liu, L. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.11.010 · Cited by 1,005 · see citing works

Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

Kucharzewska, P., Christianson, H. C., Welch, J. E., Svensson, K. J., Fredlund, E., Ringnér, M., Mörgelin, M., Bourseau-Guilmain, E., Bengzon, J., & Belting, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220998110 · Cited by 939 · see citing works

Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy

Lee, Y., Andaloussi, S. E., & Wood, M. J. A. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds317 · Cited by 936 · see citing works

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

Christianson, H. C., Svensson, K. J., van Kuppevelt, T. H., Li, J.-P., & Belting, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1304266110 · Cited by 903 · see citing works

Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth

Xin, H., Li, Y., Buller, B., Katakowski, M., Zhang, Y., Wang, X., Shang, X., Zhang, Z. G., & Chopp, M. (2012) · Stem Cells · doi:10.1002/stem.1129 · Cited by 897 · see citing works

Grape Exosome-like Nanoparticles Induce Intestinal Stem Cells and Protect Mice From DSS-Induced Colitis

Ju, S., Mu, J., Dokland, T., Zhuang, X., Wang, Q., Jiang, H., Xiang, X., Deng, Z., Wang, B., Zhang, L., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2013.64 · Cited by 880 · see citing works

Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy

Sokolova, V., Ludwig, A., Hornung, S., Rotan, O., Horn, P. A., Epple, M., & Giebel, B. (2011) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2011.05.013 · Cited by 853 · see citing works

Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery

Yeo, R. W. Y., Lai, R. C., Zhang, B., Tan, S. S., Yin, Y., Teh, B. J., & Lim, S. K. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.07.001 · Cited by 816 · see citing works

Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury

Gatti, S., Bruno, S., Deregibus, M. C., Sordi, A., Cantaluppi, V., Tetta, C., & Camussi, G. (2011) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfr015 · Cited by 814 · see citing works

Phase I Clinical Trial of Autologous Ascites-derived Exosomes Combined With GM-CSF for Colorectal Cancer

Dai, S., Wei, D., Wu, Z., Zhou, X., Wei, X., Huang, H., & Li, G. (2008) · Molecular Therapy · doi:10.1038/mt.2008.1 · Cited by 805 · see citing works

Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth

Katakowski, M., Buller, B., Zheng, X., Lü, Y., Rogers, T., Osobamiro, O. O., Shu, W., Jiang, F., & Chopp, M. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.02.019 · Cited by 748 · see citing works

Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection

Takahashi, Y., Nishikawa, M., Shinotsuka, H., Matsui, Y., Ohara, S., Imai, T., & Takakura, Y. (2013) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2013.03.013 · Cited by 729 · see citing works

Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

Wahlgren, J., Karlson, T. D. L., Brisslert, M., Sani, F. V., Telemo, E., Sunnerhagen, P., & Valadi, H. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks463 · Cited by 716 · see citing works

First-in-Humans Trial of an RNA Interference Therapeutic Targeting VEGF and KSP in Cancer Patients with Liver Involvement

Tabernero, J. M., Shapiro, G. I., LoRusso, P. M., Cervantes, A. M. R., Schwartz, G. K., Weiss, G. J., Paz-Ares, L. G., Cho, D. C., Infante, J. R., Alsina, M., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0429 · Cited by 700 · see citing works

Interaction and uptake of exosomes by ovarian cancer cells

Escrevente, C., Keller, S., Altevogt, P., & Costa, J. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-108 · Cited by 666 · see citing works

Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles

Kooijmans, S. A. A., Stremersch, S., Braeckmans, K., de Smedt, S. C., Hendrix, A., Wood, M. J. A., Schiffelers, R. M., Raemdonck, K., & Vader, P. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.08.014 · Cited by 663 · see citing works

siRNA vs. shRNA: Similarities and differences

Rao, D. D., Vorhies, J. S., Senzer, N. N., & Nemunaitis, J. J. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.04.004 · Cited by 658 · see citing works

Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes

Conde‐Vancells, J., Rodríguez‐Suárez, E., Embade, N., Gil‐Carton, D., Matthiesen, R., Valle, M., Elortza, F., Lu, S. C.-L., Mato, J. M., & Falcón‐Pérez, J. M. (2008) · Journal of Proteome Research · doi:10.1021/pr8004887 · Cited by 644 · see citing works

Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma

Kalra, H., Adda, C. G., Liem, M. K., Ang, C., Mechler, Á., Simpson, R. J., Hulett, M. D., & Mathivanan, S. (2013) · PROTEOMICS · doi:10.1002/pmic.201300282 · Cited by 625 · see citing works

Exosome lipidomics unravels lipid sorting at the level of multivesicular bodies

Subra, C., Laulagnier, K., Perret, B., & Record, M. (2006) · Biochimie · doi:10.1016/j.biochi.2006.10.014 · Cited by 623 · see citing works

Exosome-mediated delivery of siRNA in vitro and in vivo

Andaloussi, S. E., Lee, Y., Lakhal‐Littleton, S., Li, J., Seow, Y., Gardiner, C., Alvarez‐Erviti, L., Sargent, I. L., & Wood, M. J. A. (2012) · Nature Protocols · doi:10.1038/nprot.2012.131 · Cited by 602 · see citing works

Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity

Lachenal, G. M., Pernet‐Gallay, K., Chivet, M., Hemming, F. J., Belly, A., Bodon, G., Blot, B., Haase, G., Goldberg, Y., & Sadoul, R. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.11.004 · Cited by 595 · see citing works

Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.

Blaskovich, M. A., Sun, J., Cantor, A. B., Turkson, J., Jove, R., & Sebti, S. M. (2003) · PubMed · Cited by 567 · see citing works

Exosome Secretion Is Enhanced by Invadopodia and Drives Invasive Behavior

Hoshino, D., Kirkbride, K. C., Costello, K., Clark, E. S., Sinha, S., Grega‐Larson, N. E., Tyska, M. J., & Weaver, A. M. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.10.050 · Cited by 561 · see citing works

Tumor-Derived Microvesicles Promote Regulatory T Cell Expansion and Induce Apoptosis in Tumor-Reactive Activated CD8+ T Lymphocytes

Wieckowski, E. U., Visús, C., Szajnik, M. E., Szczepański, M. J., Storkus, W. J., & Whiteside, T. L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900970 · Cited by 560 · see citing works

Exosomes for targeted siRNA delivery across biological barriers

Andaloussi, S. E., Lakhal‐Littleton, S., Mäger, I., & Wood, M. J. A. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.08.008 · Cited by 545 · see citing works

Exosomes as intercellular signalosomes and pharmacological effectors

Record, M., Subra, C., Silvente‐Poirot, S., & Poirot, M. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.02.011 · Cited by 539 · see citing works

Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell–derived Exosomes to Glioblastoma Multiforme Cells Conferred Chemosensitivity

Munoz, J. L., Bliss, S. A., Greco, S. J., Ramkissoon, S. H., Ligon, K. L., & Rameshwar, P. (2013) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2013.60 · Cited by 520 · see citing works

Exosome mimetics: a novel class of drug delivery systems

Schiffelers, R. M., Kooijmans, S. A. A., Vader, P., van Dommelen, & van Solinge, W. W. (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s29661 · Cited by 517 · see citing works

Isolation and Characterization of RNA-Containing Exosomes

Lässer, C., Eldh, M., & Lötvall, J. (2012) · Journal of Visualized Experiments · doi:10.3791/3037 · Cited by 509 · see citing works

Exosomes are natural carriers of exogenous siRNA to human cells in vitro

Shtam, T. A., Kovalev, R. A., Varfolomeeva, E. Y., Makarov, E. M., Kil, Y. V., & Filatov, M. V. (2013) · Cell Communication and Signaling · doi:10.1186/1478-811x-11-88 · Cited by 499 · see citing works

Fas Ligand–Positive Membranous Vesicles Isolated from Sera of Patients with Oral Cancer Induce Apoptosis of Activated T Lymphocytes

Kim, J. W., Wieckowski, E. U., Taylor, D. D., Reichert, T. E., Watkins, S. C., & Whiteside, T. L. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.1010.11.3 · Cited by 496 · see citing works

Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo

Zhu, W., Huang, L., Li, Y., Zhang, X., Gu, J., Yan, Y., Xu, X., Wang, M., Qian, H., & Xu, W. (2012) · Cancer Letters · doi:10.1016/j.canlet.2011.10.002 · Cited by 488 · see citing works

Association of blood proteins with large unilamellar liposomes in vivo. Relation to circulation lifetimes.

Chonn, A., Semple, S. C., & Cullis, P. R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37026-7 · Cited by 461 · see citing works

Liposomal siRNA nanocarriers for cancer therapy

Özpolat, B., Sood, A. K., & Lopez‐Berestein, G. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.12.008 · Cited by 445 · see citing works

Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs

Chen, T. S., Arslan, F., Yin, Y., Tan, S. S., Lai, R. C., Choo, A. B. H., Padmanabhan, J., Lee, C. N., de Kleijn, D. P. V., & Lim, S. K. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-47 · Cited by 398 · see citing works

Tumour-derived microvesicles carry several surface determinants and mRNA of tumour cells and transfer some of these determinants to monocytes

Baj‐Krzyworzeka, M., Szatanek, R., Węglarczyk, K., Baran, J., Urbanowicz, B., Brański, P., Ratajczak, M. Z., & Zembala, M. (2005) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-005-0075-9 · Cited by 397 · see citing works

Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules

Ramteke, A. S., Ting, H., Agarwal, C., Mateen, S., Somasagara, R. R., Hussain, A., Graner, M. W., Frederick, B. A., Agarwal, R., & Deep, G. (2013) · Molecular Carcinogenesis · doi:10.1002/mc.22124 · Cited by 387 · see citing works

Exosomes Derived from Hypoxic Leukemia Cells Enhance Tube Formation in Endothelial Cells

Tadokoro, H., Umezu, T., Ohyashiki, K., Hirano, T., & Ohyashiki, J. H. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.480822 · Cited by 361 · see citing works

Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma

Grapp, M., Wrede, A., Schweizer, M., Hüwel, S., Galla, H., Snaidero, N., Simons, M., Bückers, J., Low, P. S., Urlaub, H., et al. (2013) · Nature Communications · doi:10.1038/ncomms3123 · Cited by 337 · see citing works

Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth

Mizrak, A., Bolukbasi, M. F., Ozdener, G. B., Brenner, G. J., Madlener, S., Erkan, E. P., Ströbel, T., Breakefield, X. O., & Saydam, O. (2013) · Molecular Therapy · doi:10.1038/mt.2012.161 · Cited by 337 · see citing works

The EGF receptor is required for efficient liver regeneration

Natarajan, A., Wagner, B., & Sibilia, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704126104 · Cited by 320 · see citing works

Role of Exosomes/Microvesicles in the Nervous System and Use in Emerging Therapies

Lai, C. P., & Breakefield, X. O. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00228 · Cited by 315 · see citing works

Determining the Effects of Lipophilic Drugs on Membrane Structure by Solid-State NMR Spectroscopy: The Case of the Antioxidant Curcumin

Barry, J., Fritz, M., Brender, J., Smith, P. E. S., Lee, D.-K., & Ramamoorthy, A. (2009) · Journal of the American Chemical Society · doi:10.1021/ja809217u · Cited by 315 · see citing works

Microvesicles Derived from Human Bone Marrow Mesenchymal Stem Cells Inhibit Tumor Growth

Bruno, S., Collino, F., Deregibus, M. C., Grange, C., Tetta, C., & Camussi, G. (2012) · Stem Cells and Development · doi:10.1089/scd.2012.0304 · Cited by 309 · see citing works

Exosome formation during maturation of mammalian and avian reticulocytes: Evidence that exosome release is a major route for externalization of obsolete membrane proteins

Johnstone, R. M., Mathew, A., Mason, A. B., & Teng, K. (1991) · Journal of Cellular Physiology · doi:10.1002/jcp.1041470105 · Cited by 300 · see citing works

Maximizing exosome colloidal stability following electroporation

Hood, J. L., Scott, M. J., & Wickline, S. A. (2013) · Analytical Biochemistry · doi:10.1016/j.ab.2013.12.001 · Cited by 297 · see citing works

Microvesicle-associated AAV Vector as a Novel Gene Delivery System

Maguire, C. A., Balaj, L., Sivaraman, S., Crommentuijn, M. H., Ericsson, M., Mincheva-Nilsson, L., Baranov, V., Gianni, D., Tannous, B. A., Sena-Esteves, M., et al. (2012) · Molecular Therapy · doi:10.1038/mt.2011.303 · Cited by 283 · see citing works

The microvesicle as a vehicle for EMMPRIN in tumor–stromal interactions

Sidhu, S., Mengistab, A., Tauscher, A. N., LaVail, J. H., & Basbaum, C. B. (2004) · Oncogene · doi:10.1038/sj.onc.1207070 · Cited by 279 · see citing works

Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases

Gressner, O. A., & Gressner, A. M. (2008) · Liver International · doi:10.1111/j.1478-3231.2008.01826.x · Cited by 272 · see citing works

Competitive Interactions of Cancer Cells and Normal Cells via Secretory MicroRNAs

Kosaka, N., Iguchi, H., Yoshioka, Y., Hagiwara, K., Takeshita, F., & Ochiya, T. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.288662 · Cited by 267 · see citing works

A Systematic Review of MicroRNA in Glioblastoma Multiforme: Micro-modulators in the Mesenchymal Mode of Migration and Invasion

Møller, H. G., Rasmussen, A. P., Andersen, H. H., Johnsen, K. B., Henriksen, M., & Duroux, M. C. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8349-7 · Cited by 266 · see citing works

Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells

Chen, L., Charrier, A., Zhou, Y., Chen, R., Yu, B., Agarwal, K., Tsukamoto, H., Lee, J. L., Paulaitis, M. E., & Brigstock, D. R. (2013) · Hepatology · doi:10.1002/hep.26768 · Cited by 264 · see citing works

Detachment of Breast Tumor Cells Induces Rapid Secretion of Exosomes Which Subsequently Mediate Cellular Adhesion and Spreading

Koumangoye, R. B., Sakwe, A. M., Goodwin, J. S., Patel, T., & Ochieng, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024234 · Cited by 227 · see citing works

Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity

Bryniarski, K., Ptak, W., Jayakumar, A., Püellmann, K., Caplan, M. J., Chairoungdua, A., Lü, J., Adams, B. D., Sikora, E., Nazimek, K., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.04.048 · Cited by 214 · see citing works

Proteomic Profiling of Exosomes Leads to the Identification of Novel Biomarkers for Prostate Cancer

Duijvesz, D., Burnum-Johnson, K., Gritsenko, M. A., Hoogland, A. M., den Berg, M. S. V., Willemsen, R., Luider, T. M., Paša‐Tolić, L., & Jenster, G. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082589 · Cited by 208 · see citing works

RNA expression patterns in serum microvesicles from patients with glioblastoma multiforme and controls

Noerholm, M., Balaj, L., Limperg, T., Salehi, A., Zhu, L. D., Hochberg, F. H., Breakefield, X. O., Carter, B. S., & Skog, J. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-22 · Cited by 190 · see citing works

Functional MicroRNA Is Transferred between Glioma Cells

Katakowski, M., Buller, B., Wang, X., Rogers, T., & Chopp, M. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0604 · Cited by 186 · see citing works

Extracellular vesicles – vehicles that spread cancer genes

Rak, J. W., & Guha, A. (2012) · BioEssays · doi:10.1002/bies.201100169 · Cited by 184 · see citing works

Signaling inputs to invadopodia and podosomes

Hoshino, D., Branch, K. M., & Weaver, A. M. (2013) · Journal of Cell Science · doi:10.1242/jcs.079475 · Cited by 178 · see citing works

Microfluidic fabrication of cell-derived nanovesicles as endogenous RNA carriers

Jo, W., Jeong, D., Kim, J., Cho, S., Jang, S. C., Han, C., Kang, J. Y., Gho, Y. S., & Park, J. (2014) · Lab on a Chip · doi:10.1039/c3lc50993a · Cited by 167 · see citing works

Hepatic cell-to-cell transmission of small silencing RNA can extend the therapeutic reach of RNA interference (RNAi)

Pan, Q., Ramakrishnaiah, V., Henry, S. D., Fouraschen, S. M. G., de Ruiter, P. E., Kwekkeboom, J., Tilanus, H. W., Janssen, H. L. A., & van der Laan, L. J. W. (2011) · Gut · doi:10.1136/gutjnl-2011-300449 · Cited by 163 · see citing works

The roles of extracellular vesicles in cancer biology: Toward the development of novel cancer biomarkers

Katsuda, T., Kosaka, N., & Ochiya, T. (2013) · PROTEOMICS · doi:10.1002/pmic.201300389 · Cited by 161 · see citing works

MiR-146b-5p Suppresses EGFR Expression and ReducesIn VitroMigration and Invasion of Glioma

Katakowski, M., Zheng, X., Jiang, F., Rogers, T., Szalad, A., & Chopp, M. (2010) · Cancer Investigation · doi:10.3109/07357907.2010.512596 · Cited by 161 · see citing works

Epidermal growth factor receptor localized to exosome membranes as a possible biomarker for lung cancer diagnosis

Yamashita, T., Kamada, H., Kanasaki, S., Maeda, Y., Nagano, K., Abe, Y., Inoue, M., Yoshioka, Y., Tsutsumi, Y. M., Katayama, S., et al. (2013) · Die Pharmazie · doi:10.31083/ph.2013.3599 · Cited by 135 · see citing works

Exosomes bearing HLA-G are released by melanoma cells

Riteau, B., Faure, F., Menier, C., Viel, S., Carosella, E. D., Amigorena, S., & Rouas‐Freiss, N. (2003) · Human Immunology · doi:10.1016/j.humimm.2003.08.344 · Cited by 134 · see citing works

Lipid-Based Nanoparticles in The Systemic Delivery of siRNA

Lin, Q., Chen, J., Zhang, Z., & Zheng, G. (2013) · Nanomedicine · doi:10.2217/nnm.13.192 · Cited by 133 · see citing works

Exosomal RNA as biomarkers and the therapeutic potential of exosome vectors

Lässer, C. (2012) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2012.680018 · Cited by 130 · see citing works

Emerging technologies in extracellular vesicle-based molecular diagnostics

Jia, S., Zocco, D., Samuels, M., Chou, M. F., Chammas, R., Skog, J., Zarovni, N., Momen-Heravi, F., & Kuo, W. (2014) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2014.893828 · Cited by 130 · see citing works

Tumour-derived microvesicles modulate biological activity of human monocytes

Baj‐Krzyworzeka, M., Szatanek, R., Węglarczyk, K., Baran, J., & Zembala, M. (2007) · Immunology Letters · doi:10.1016/j.imlet.2007.07.014 · Cited by 128 · see citing works

Liposomal cancer therapy: exploiting tumor characteristics

Kaasgaard, T., & Andresen, T. L. (2010) · Expert Opinion on Drug Delivery · doi:10.1517/17425240903427940 · Cited by 120 · see citing works

Immature Dendritic Cell-Derived Exosomes: a Promise Subcellular Vaccine for Autoimmunity

Yin, W., Ouyang, S., Li, Y., Xiao, B., & Yang, H. (2012) · Inflammation · doi:10.1007/s10753-012-9539-1 · Cited by 107 · see citing works

Attenuation of Mouse Melanoma by A/C Magnetic Field after Delivery of Bi-Magnetic Nanoparticles by Neural Progenitor Cells

Rachakatla, R. S., Balivada, S., Seo, G., Myers, C. B., Wang, H., Samarakoon, T., Dani, R. K., Pyle, M. M., Kroh, F. O., Walker, B., et al. (2010) · ACS Nano · doi:10.1021/nn100870z · Cited by 91 · see citing works

Introduction of theCIITAgene into tumor cells produces exosomes with enhanced anti-tumor effects

Lee, Y. S., Kim, S. H., Cho, J. A., & Kim, C. W. (2011) · Experimental & Molecular Medicine · doi:10.3858/emm.2011.43.5.029 · Cited by 88 · see citing works

Apoptosis-Independent Alterations in Membrane Dynamics Induced by Curcumin

Jaruga, E., Sokal, A., Chrul, S., & Bartosz, G. (1998) · Experimental Cell Research · doi:10.1006/excr.1998.4225 · Cited by 80 · see citing works

The use of 19F spectroscopy and diffusion-weighted MRI to evaluate differences in gene-dependent enzyme prodrug therapies

Hamstra, D. A., Lee, K. C., Tychewicz, J. M., Schepkin, V. D., Moffat, B. A., Chen, M., Dornfeld, K. J., Lawrence, T. S., Chenevert, T. L., Ross, B. D., et al. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.07.022 · Cited by 77 · see citing works

Nanofilaments on glioblastoma exosomes revealed by peak force microscopy

Sharma, S., Das, K., Woo, J., & Gimzewski, J. K. (2014) · Journal of The Royal Society Interface · doi:10.1098/rsif.2013.1150 · Cited by 65 · see citing works

MicroRNA Expression Signatures Determine Prognosis and Survival in Glioblastoma Multiforme—a Systematic Overview

Henriksen, M., Johnsen, K. B., Andersen, H. H., Pilgaard, L., & Duroux, M. C. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8668-y · Cited by 57 · see citing works

Multiple Microsurgical Resections for Repeated Recurrence of Glioblastoma Multiforme

Hong, B., Wiese, B., Bremer, M., Heissler, H. E., Heidenreich, F., Krauss, J. K., & Nakamura, M. (2012) · American Journal of Clinical Oncology · doi:10.1097/coc.0b013e3182467bb1 · Cited by 55 · see citing works

Clinical implications of microRNAs in human glioblastoma

Mizoguchi, M., Guan, Y., Yoshimoto, K., Hata, N., Amano, T., Nakamizo, A., & Sasaki, T. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00019 · Cited by 55 · see citing works

Targeted Antiepidermal Growth Factor Receptor (Cetuximab) Immunoliposomes Enhance Cellular Uptake In Vitro and Exhibit Increased Accumulation in an Intracranial Model of Glioblastoma Multiforme

Mortensen, J. H., Jeppesen, M., Pilgaard, L., Agger, R., Duroux, M. C., Zachar, V., & Moos, T. (2013) · Journal of Drug Delivery · doi:10.1155/2013/209205 · Cited by 53 · see citing works

Controlled Biodistribution of Highly Lipophilic Drugs with Various Parenteral Formulations

Takino, T., Nakajima, C., Takakura, Y., Sezaki, H., & Hashida, M. (1993) · Journal of drug targeting · doi:10.3109/10611869308996067 · Cited by 45 · see citing works

Neuro-oncologic Applications of Exosomes, Microvesicles, and Other Nano-Sized Extracellular Particles

Gonda, D. D., Akers, J. C., Kim, R., Kalkanis, S. N., Hochberg, F. H., Chen, C. C., & Carter, B. S. (2012) · Neurosurgery · doi:10.1227/neu.0b013e3182846e63 · Cited by 42 · see citing works

Targeting the Epidermal Growth Factor Receptor in Solid Tumor Malignancies

Nedergaard, M. K., Hedegaard, C. J., & Poulsen, H. S. (2012) · BioDrugs · doi:10.2165/11599760-000000000-00000 · Cited by 41 · see citing works

Effector memory regulatory T-cell expansion marks a pivotal point of immune escape in myelodysplastic syndromes

Mailloux, A. W., & Epling‐Burnette, P. K. (2012) · OncoImmunology · doi:10.4161/onci.22654 · Cited by 17 · see citing works

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

Kamerkar, S., LeBleu, V. S., Sugimoto, H., Yang, S., Ruivo, C. F., Melo, S. A., Lee, J. J., & Kalluri, R. (2017) · Nature · doi:10.1038/nature22341 · Cited by 2,639 · see citing works

Exosomes as drug delivery vehicles for Parkinson’s disease therapy

Haney, M. J., Klyachko, N. L., Zhao, Y., Gupta, R., Plotnikova, E. G., He, Z., Patel, T., Piroyan, A., Sokolsky, M., Kabanov, A. V., et al. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.03.033 · Cited by 2,009 · see citing works

The biology and function of exosomes in cancer

Kalluri, R. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81135 · Cited by 1,849 · see citing works

Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper

Lener, T., Gimona, M., Aigner, L., Börger, V., Buzás, E. I., Camussi, G., Chaput, N., Chatterjee, D., Court, F. A., Portillo, H. A. D., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.30087 · Cited by 1,615 · see citing works

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

Kim, M. S., Haney, M. J., Zhao, Y., Mahajan, V., Le‐Deygen, I. M., Klyachko, N. L., Inskoe, E., Piroyan, A., Sokolsky‐Papkov, M., Okolie, O., et al. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.10.012 · Cited by 1,498 · see citing works

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

Zhang, L., Zhang, S., Yao, J., Lowery, F. J., Zhang, Q., Huang, W.-C., Li, P., Li, M., Wang, X., Zhang, C., et al. (2015) · Nature · doi:10.1038/nature15376 · Cited by 1,080 · see citing works

Nanomaterials for In Vivo Imaging

Smith, B. R., & Gambhir, S. S. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00073 · Cited by 1,076 · see citing works

The Smart Drug Delivery System and Its Clinical Potential

Liu, D., Yang, F., Xiong, F., & Gu, N. (2016) · Theranostics · doi:10.7150/thno.14858 · Cited by 1,066 · see citing works

Lipids in exosomes: current knowledge and the way forward

Skotland, T., Sandvig, K., & Llorente, A. (2017) · Progress in Lipid Research · doi:10.1016/j.plipres.2017.03.001 · Cited by 1,030 · see citing works

LncRNA: A link between RNA and cancer

Yang, G., Lu, X., & Yuan, L. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.08.012 · Cited by 992 · see citing works

Exosomes in cancer development, metastasis, and immunity

Zhang, L., & Yu, D. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.04.004 · Cited by 967 · see citing works

Bovine milk-derived exosomes for drug delivery

Munagala, R., Aqil, F., Jeyabalan, J., & Gupta, R. C. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.10.020 · Cited by 936 · see citing works

Generation and testing of clinical-grade exosomes for pancreatic cancer

Mendt, M. C., Kamerkar, S., Sugimoto, H., McAndrews, K. M., Wu, C.-C., Gagea, M., Yang, S., Blanko, E. V. R., Peng, Q., Ma, X., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.99263 · Cited by 795 · see citing works

Engineering hybrid exosomes by membrane fusion with liposomes

Sato, Y. T., Umezaki, K., Sawada, S., Mukai, S.-A., Sasaki, Y., Harada, N., Shiku, H., & Akiyoshi, K. (2016) · Scientific Reports · doi:10.1038/srep21933 · Cited by 744 · see citing works

A Protocol for Exosome Isolation and Characterization: Evaluation of Ultracentrifugation, Density-Gradient Separation, and Immunoaffinity Capture Methods

Greening, D. W., Xu, R., Ji, H. L., Tauro, B. J., & Simpson, R. J. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2550-6_15 · Cited by 723 · see citing works

Isolation of Exosomes from Blood Plasma: Qualitative and Quantitative Comparison of Ultracentrifugation and Size Exclusion Chromatography Methods

Baranyai, T., Herczeg, K., Onódi, Z., Voszka, I., Módos, K., Marton, N., Nagy, G., Mäger, I., Wood, M. J. A., Andaloussi, S. E., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145686 · Cited by 677 · see citing works

Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: In vitro and in vivo evaluations

Kim, M. S., Haney, M. J., Zhao, Y., Yuan, D., Deygen, I., Klyachko, N. L., Kabanov, A. V., & Batrakova, E. V. (2018) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.09.011 · Cited by 663 · see citing works

Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine

Contreras-Naranjo, J. C., Wu, H., & Ugaz, V. M. (2017) · Lab on a Chip · doi:10.1039/c7lc00592j · Cited by 650 · see citing works

Lipids and Lipid Derivatives for RNA Delivery

Zhang, Y., Sun, C., Wang, C., Jankovic, K. E., & Dong, Y. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00244 · Cited by 638 · see citing works

Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells

Saari, H., Lázaro-Ibáñez, E., Viitala, T., Vuorimaa-Laukkanen, E., Siljander, P., & Yliperttula, M. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.09.031 · Cited by 613 · see citing works

Prospects and challenges of extracellular vesicle-based drug delivery system: considering cell source

Meng, W., He, C., Hao, Y., Wang, L., Li, L., & Zhu, G. (2020) · Drug Delivery · doi:10.1080/10717544.2020.1748758 · Cited by 618 · see citing works

Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery

Antimisiaris, S. G., Mourtas, S., & Marazioti, A. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10040218 · Cited by 605 · see citing works

Alzheimer's Disease: Treatment Strategies and Their Limitations.

Passeri, E., Elkhoury, K., Morsink, M., Broersen, K., Linder, M., Tamayol, A., Malaplate, C., Yen, F. T., & Arab-Tehrany, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213954 · Cited by 592 · see citing works

Recent advancements in the use of exosomes as drug delivery systems

Bunggulawa, E. J., Wang, W., Yin, T., Wang, N., Durkan, C., Wang, Y., & Wang, G. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0403-9 · Cited by 600 · see citing works

Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells

Zhu, X., Badawi, M. A., Pomeroy, S. M., Sutaria, D. S., Xie, Z., Baek, A., Jiang, J., Elgamal, O. A., Mo, X. M., Perle, K. L., et al. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1324730 · Cited by 588 · see citing works

Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson’s disease

Qu, M., Lin, Q., Huang, L., Fu, Y., Wang, L., He, S., Fu, Y., Yang, S., Zhang, Z., Zhang, L., et al. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.08.035 · Cited by 543 · see citing works

Cancer-derived exosomes as a delivery platform of CRISPR/Cas9 confer cancer cell tropism-dependent targeting

Kim, S. M., Yang, Y., Oh, S. J., Hong, Y., Seo, M., & Jang, M. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.09.013 · Cited by 481 · see citing works

Cell membrane-derived nanomaterials for biomedical applications

Fang, R. H., Jiang, Y., Fang, J. C., & Zhang, L. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.02.041 · Cited by 470 · see citing works

Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis

Zhao, L., Gu, C., Gan, Y. H., Shao, L., Chen, H., & Zhu, H. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.12.005 · Cited by 443 · see citing works

Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy

Gao, X., Ran, N., Dong, X., Zuo, B., Yang, R., Zhou, Q., Moulton, H. M., Seow, Y., & Yin, H. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat0195 · Cited by 426 · see citing works

Exosomes: The next generation of endogenous nanomaterials for advanced drug delivery and therapy

Liao, W., Du, Y., Zhang, C., Pan, F., Yao, Y., Zhang, T., & Peng, Q. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.12.045 · Cited by 416 · see citing works

In Vivo Neuroimaging of Exosomes Using Gold Nanoparticles

Betzer, O., Perets, N., Angel, A., Motiei, M., Sadan, T., Yadid, G., Offen, D., & Popovtzer, R. (2017) · ACS Nano · doi:10.1021/acsnano.7b04495 · Cited by 404 · see citing works

Progress in brain targeting drug delivery system by nasal route

Khan, A. R., Liu, M., Khan, M. W., & Zhai, G. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.09.001 · Cited by 402 · see citing works

Simplified protocol for flow cytometry analysis of fluorescently labeled exosomes and microvesicles using dedicated flow cytometer

Pospíchalová, V., Svoboda, J., Dave, Z., Kotrbova, A. V., Kaiser, K., Klemová, D., Ilkovics, L., Hampl, A., Crha, I., Jandáková, E., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.25530 · Cited by 388 · see citing works

Interleukin 3- receptor targeted exosomes inhibit in vitro and in vivo Chronic Myelogenous Leukemia cell growth

Bellavia, D., Raimondo, S., Calabrese, G., Forte, S., Cristaldi, M., Patinella, A., Memeo, L., Manno, M., Raccosta, S., Diana, P., et al. (2017) · Theranostics · doi:10.7150/thno.17092 · Cited by 383 · see citing works

Challenges in the development and establishment of exosome-based drug delivery systems

Wang, J., Chen, D., & Ho, E. A. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.10.020 · Cited by 387 · see citing works

Responsive Exosome Nano-bioconjugates for Synergistic Cancer Therapy

Nie, W., Wu, G., Zhang, J., Huang, L., Ding, J., Jiang, A., Zhang, Y., Liu, Y., Li, J., Pu, K., et al. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201912524 · Cited by 376 · see citing works

Metal–Organic Framework-Functionalized Paper-Based Electrochemical Biosensor for Ultrasensitive Exosome Assay

Liu, X., Gao, X., Yang, L., Zhao, Y., & Li, F. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c02286 · Cited by 336 · see citing works

Curcumin-primed exosomes potently ameliorate cognitive function in AD mice by inhibiting hyperphosphorylation of the Tau protein through the AKT/GSK-3β pathway

Wang, H., Sui, H., Zheng, Y., Jiang, Y., Shi, Y., Liang, J., & Zhao, L. (2019) · Nanoscale · doi:10.1039/c9nr01255a · Cited by 324 · see citing works

Exosomes as novel bio-carriers for gene and drug delivery

Jiang, X., & Gao, J. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.02.038 · Cited by 321 · see citing works

Exosomes derived from mesenchymal stem cells repair a Parkinson’s disease model by inducing autophagy

Chen, H.-X., Liang, F.-C., Gu, P., Xu, B.-L., Xu, H.-J., Wang, W.-T., Hou, J.-Y., Xie, D.-X., Chai, X.-Q., & An, S.-J. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-2473-5 · Cited by 319 · see citing works

What is the blood concentration of extracellular vesicles? Implications for the use of extracellular vesicles as blood-borne biomarkers of cancer

Johnsen, K. B., Gudbergsson, J. M., Andresen, T. L., & Simonsen, J. B. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.11.006 · Cited by 318 · see citing works

Microvesicles Derived from Human Bone Marrow Mesenchymal Stem Cells Inhibit Tumor Growth

Bruno, S., Collino, F., Deregibus, M. C., Grange, C., Tetta, C., & Camussi, G. (2012) · Stem Cells and Development · doi:10.1089/scd.2012.0304 · Cited by 309 · see citing works

Advances in Exosome-Based Drug Delivery and Tumor Targeting: From Tissue Distribution to Intracellular Fate

Shao, J., Zaro, J. L., & Shen, Y. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s281890 · Cited by 306 · see citing works

Extracellular vesicles in renal disease

Karpman, D., Ståhl, A.-L., & Arvidsson, I. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.98 · Cited by 292 · see citing works

Precipitation with polyethylene glycol followed by washing and pelleting by ultracentrifugation enriches extracellular vesicles from tissue culture supernatants in small and large scales

Ludwig, A., de Miroschedji, K., Doeppner, T. R., Börger, V., Ruesing, J., Rebmann, V., Durst, S., Jansen, S., Bremer, M., Behrmann, E., et al. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1528109 · Cited by 294 · see citing works

Curcumin Delivery Mediated by Bio-Based Nanoparticles: A Review

Nasery, M. M., Abadi, B., Poormoghadam, D., Zarrabi, A., Keyhanvar, P., Khanbabaei, H., Ashrafizadeh, M., Mohammadinejad, R., Tavakol, S., & Sethi, G. (2020) · Molecules · doi:10.3390/molecules25030689 · Cited by 291 · see citing works

Engineering Exosomes for Cancer Therapy

Gilligan, K., & Dwyer, R. M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061122 · Cited by 290 · see citing works

Recent Advances in Nanoparticle-Based Cancer Drug and Gene Delivery

Amreddy, N., Babu, A., Muralidharan, R., Panneerselvam, J., Srivastava, A., Ahmed, R. A., Mehta, M., Munshi, A., & Ramesh, R. (2017) · Advances in cancer research · doi:10.1016/bs.acr.2017.11.003 · Cited by 288 · see citing works

Reprogramming Exosomes as Nanoscale Controllers of Cellular Immunity

Cheng, Q., Shi, X., Han, M., Smbatyan, G., Lenz, H., & Zhang, Y. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b10047 · Cited by 286 · see citing works

Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets

Szabó, G., & Momen‐Heravi, F. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.71 · Cited by 283 · see citing works

Rational Design of Nanocarriers for Intracellular Protein Delivery

Qin, X., Yu, C., Wei, J., Li, L., Zhang, C., Wu, Q., Liu, J., Yao, S. Q., & Huang, W. (2019) · Advanced Materials · doi:10.1002/adma.201902791 · Cited by 281 · see citing works

Cell type-specific and common characteristics of exosomes derived from mouse cell lines: Yield, physicochemical properties, and pharmacokinetics

Charoenviriyakul, C., Takahashi, Y., Morishita, M., Matsumoto, A., Nishikawa, M., & Takakura, Y. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.10.009 · Cited by 280 · see citing works

A New Approach for Loading Anticancer Drugs Into Mesenchymal Stem Cell-Derived Exosome Mimetics for Cancer Therapy

Kalimuthu, S., Gangadaran, P., Rajendran, R. L., Zhu, L., Oh, J. M., Lee, H., Gopal, A., Baek, S. H., Jeong, S. Y., Lee, S., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01116 · Cited by 269 · see citing works

Bio-inspired engineering of cell- and virus-like nanoparticles for drug delivery

Parodi, A., Molinaro, R., Sushnitha, M., Evangelopoulos, M., Martinez, J. O., Arrighetti, N., Corbo, C., & Tasciotti, E. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.09.020 · Cited by 265 · see citing works

Pathologic function and therapeutic potential of exosomes in cardiovascular disease

Ailawadi, S., Wang, X., Gu, H., & Fan, G. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.10.008 · Cited by 259 · see citing works

Extracellular vesicles as a platform for membrane‐associated therapeutic protein delivery

Yang, Y., Hong, Y., Cho, E., Kim, G. B., & Kim, I. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1440131 · Cited by 259 · see citing works

Potential Use of Exosomes as Diagnostic Biomarkers and in Targeted Drug Delivery: Progress in Clinical and Preclinical Applications

Huda, M. N., Nafiujjaman, M., Deaguero, I. G., Okonkwo, J., Hill, M. L., Kim, T. H., & Nurunnabi, M. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c00217 · Cited by 262 · see citing works

Advances in plant-derived edible nanoparticle-based lipid nano-drug delivery systems as therapeutic nanomedicines

Yang, C., Zhang, M., & Merlin, D. (2018) · Journal of Materials Chemistry B · doi:10.1039/c7tb03207b · Cited by 256 · see citing works

Exosome-mediated delivery of functionally active miRNA-142-3p inhibitor reduces tumorigenicity of breast cancer in vitro and in vivo

Naseri, Z., Oskuee, R. K., Jaafari, M. R., & Forouzandeh, M. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s182384 · Cited by 253 · see citing works

Targeted doxorubicin-loaded mesenchymal stem cells-derived exosomes as a versatile platform for fighting against colorectal cancer

Bagheri, E., Abnous, K., Farzad, S. A., Taghdisi, S. M., Ramezani, M., & Alibolandi, M. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118369 · Cited by 252 · see citing works

Designer Exosomes: A New Platform for Biotechnology Therapeutics

Jafari, D., Shajari, S., Jafari, R., Mardi, N., Gomari, H., Ganji, F., Moghadam, M. F., & Samadikuchaksaraei, A. (2020) · BioDrugs · doi:10.1007/s40259-020-00434-x · Cited by 251 · see citing works

Macrophage-Derived Extracellular Vesicles as Drug Delivery Systems for Triple Negative Breast Cancer (TNBC) Therapy

Haney, M. J., Zhao, Y., Jin, Y. S., Li, S. M., Bagó, J. R., Klyachko, N. L., Kabanov, A. V., & Batrakova, E. V. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09884-9 · Cited by 246 · see citing works

Towards microfluidic-based exosome isolation and detection for tumor therapy

Wang, J., Ma, P., Kim, D. H., Liu, B., & Demirci, U. (2021) · Nano Today · doi:10.1016/j.nantod.2020.101066 · Cited by 245 · see citing works

Mesenchymal stem cells as natural biofactories for exosomes carrying miR-124a in the treatment of gliomas

Lang, F., Hossain, A., Gumin, J., Momin, E. N., Shimizu, Y., Ledbetter, D., Shahar, T., Yamashita, S., Kerrigan, B. C. P., Fueyo-Margareto, J., et al. (2017) · Neuro-Oncology · doi:10.1093/neuonc/nox152 · Cited by 240 · see citing works

Peptides as multifunctional players in cancer therapy

Vadevoo, S. M. P., Gurung, S., Lee, H., Gunassekaran, G. R., Lee, S.-M., Yoon, J., Lee, Y.-K., & Lee, B.-H. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01016-x · Cited by 235 · see citing works

Autologous tumor cell–derived microparticle-based targeted chemotherapy in lung cancer patients with malignant pleural effusion

Guo, M., Wu, F., Hu, G., Chen, L., Xu, J., Xu, P., Wang, X., Li, Y., Liu, S., Zhang, S., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aat5690 · Cited by 234 · see citing works

Hydrogel Encapsulation of Mesenchymal Stem Cells and Their Derived Exosomes for Tissue Engineering

Khayambashi, P., Iyer, J. S., Pillai, S., Upadhyay, A., Zhang, Y., & Tran, S. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020684 · Cited by 235 · see citing works

Emerging strategies to target RAS signaling in human cancer therapy

Chen, K., Zhang, Y., Qian, L. M., & Wang, P. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01127-w · Cited by 231 · see citing works

Development and MPI tracking of novel hypoxia-targeted theranostic exosomes

Jung, K. O., Jo, H., Yu, J. H., Gambhir, S. S., & Pratx, G. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.05.048 · Cited by 231 · see citing works

Mesenchymal Stem Cell-Derived Extracellular Vesicles as Therapeutics and as a Drug Delivery Platform

Baek, G., Choi, H., Kim, Y., Lee, H.-C., & Choi, C. (2019) · Stem Cells Translational Medicine · doi:10.1002/sctm.18-0226 · Cited by 229 · see citing works

Exosome separation using microfluidic systems: size‐based, immunoaffinity‐based and dynamic methodologies

Yang, F., Liao, X., Tian, Y. Y., & Li, G. (2017) · Biotechnology Journal · doi:10.1002/biot.201600699 · Cited by 226 · see citing works

RNAi delivery by exosome-mimetic nanovesicles – Implications for targeting c-Myc in cancer

Lunavat, T. R., Jang, S. C., Nilsson, L. M., Park, H. T., Repiská, G., Lässer, C., Nilsson, J. A., Gho, Y. S., & Lötvall, J. O. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.06.024 · Cited by 225 · see citing works

Extracellular Vesicles and Their Roles in Cancer Progression

Chang, W.-H., Cerione, R. A., & Antonyak, M. A. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-0759-6_10 · Cited by 226 · see citing works

Exosomal formulation of anthocyanidins against multiple cancer types

Munagala, R., Aqil, F., Jeyabalan, J., Agrawal, A. K., Mudd, A. M., Kyakulaga, A. H., Singh, I. P., Vadhanam, M. V., & Gupta, R. C. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.02.004 · Cited by 224 · see citing works

Exosomes as drug carriers for cancer therapy and challenges regarding exosome uptake

Zhao, X., Wu, D. L., Ma, X., Wang, J., Hou, W., & Zhang, W. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110237 · Cited by 220 · see citing works

A comprehensive review of challenges and advances in exosome-based drug delivery systems

Palakurthi, S. S., Shah, B. M., Kapre, S., Charbe, N. B., Immanuel, S., Pasham, S., Thalla, M., Jain, A., & Palakurthi, S. (2024) · Nanoscale Advances · doi:10.1039/d4na00501e · Cited by 246 · see citing works

Chemically Edited Exosomes with Dual Ligand Purified by Microfluidic Device for Active Targeted Drug Delivery to Tumor Cells

Wang, J., Li, W., Zhang, L., Ban, L., Chen, P., Du, W., Feng, X., & Liu, B. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b06464 · Cited by 218 · see citing works

Aptamer-Functionalized Exosomes: Elucidating the Cellular Uptake Mechanism and the Potential for Cancer-Targeted Chemotherapy

Zou, J., Shi, M., Liu, X., Jin, C. Y., Xing, X., Qiu, L., & Tan, W. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.8b05204 · Cited by 214 · see citing works

Modulation of tissue tropism and biological activity of exosomes and other extracellular vesicles: New nanotools for cancer treatment

Kooijmans, S. A. A., Schiffelers, R. M., Zarovni, N., & Vago, R. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.07.006 · Cited by 215 · see citing works

Methods for the physical characterization and quantification of extracellular vesicles in biological samples

Rupert, D. L. M., Claudio, V., Lässer, C., & Bally, M. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.07.028 · Cited by 212 · see citing works

Extracellular vesicles as a drug delivery system: A systematic review of preclinical studies

de Castilla, P. E. M., Tong, L., Huang, C., Sofias, A. M., Pastorin, G., Chen, X. S., Storm, G., Schiffelers, R. M., & Wang, J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.05.011 · Cited by 214 · see citing works

Exosomes as Naturally Occurring Vehicles for Delivery of Biopharmaceuticals: Insights from Drug Delivery to Clinical Perspectives

Butreddy, A., Kommineni, N., & Dudhipala, N. R. (2021) · Nanomaterials · doi:10.3390/nano11061481 · Cited by 214 · see citing works

Evaluation of electroporation-induced adverse effects on adipose-derived stem cell exosomes

Johnsen, K. B., Gudbergsson, J. M., Skov, M. N., Christiansen, G., Gurevich, L., Moos, T., & Duroux, M. C. (2016) · Cytotechnology · doi:10.1007/s10616-016-9952-7 · Cited by 211 · see citing works

Engineering patient-specific cancer immunotherapies

Scheetz, L., Park, K. S., Li, Q., Lowenstein, P. R., Castro, M. G., Schwendeman, A., & Moon, J. J. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0436-x · Cited by 208 · see citing works

Recent Advances in Biosensors for Detecting Cancer-Derived Exosomes

Cheng, N., Du, D., Wang, X., Liu, D., Xu, W., Luo, Y., & Lin, Y. (2019) · Trends in biotechnology · doi:10.1016/j.tibtech.2019.04.008 · Cited by 208 · see citing works

Increased Circulating Exosomal miRNA-223 Is Associated with Acute Ischemic Stroke

Chen, Y., Song, Y., Huang, J., Qu, M., Zhang, Y., Geng, J., Zhang, Z., Liu, J., & Yang, G.-Y. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00057 · Cited by 207 · see citing works

Exosome-based nanocarriers as bio-inspired and versatile vehicles for drug delivery: recent advances and challenges

Zhang, M., Zang, X., Wang, M., Li, Z., Qiao, M., Hu, H., & Chen, D. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb00170k · Cited by 210 · see citing works

Exosomal miRNAs in central nervous system diseases: biomarkers, pathological mediators, protective factors and therapeutic agents

Xia, X., Wang, Y., Huang, Y., Zhang, H., Lu, H., & Zheng, J. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101694 · Cited by 206 · see citing works

Nucleolin-targeted Extracellular Vesicles as a Versatile Platform for Biologics Delivery to Breast Cancer

Wang, Y., Chen, X., Tian, B., Liu, J., Yang, L., Zeng, L., Chen, T., Hong, A., & Wang, X. (2017) · Theranostics · doi:10.7150/thno.16532 · Cited by 197 · see citing works

More Than Tiny Sacks

Kishore, R., & Khan, M. (2016) · Circulation Research · doi:10.1161/circresaha.115.307654 · Cited by 195 · see citing works

Paclitaxel incorporated exosomes derived from glioblastoma cells: comparative study of two loading techniques

Salarpour, S., Forootanfar, H., Pournamdari, M., Ahmadi‐Zeidabadi, M., Esmaeeli, M., & Pardakhty, A. (2019) · DARU Journal of Pharmaceutical Sciences · doi:10.1007/s40199-019-00280-5 · Cited by 197 · see citing works

Exosomes and their role in tumorigenesis and anticancer drug resistance

Milman, N., Ginini, L., & Gil, Z. (2019) · Drug Resistance Updates · doi:10.1016/j.drup.2019.07.003 · Cited by 192 · see citing works

Exosomes derived from bone marrow mesenchymal stromal cells promote remyelination and reduce neuroinflammation in the demyelinating central nervous system

Zhang, J., Buller, B., Zhang, Z. G., Zhang, Y., Lü, M., Rosene, D. L., Medalla, M., Moore, T. L., & Chopp, M. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113895 · Cited by 195 · see citing works

TNF-Related Apoptosis-Inducing Ligand (TRAIL)–Armed Exosomes Deliver Proapoptotic Signals to Tumor Site

Rivoltini, L., Chiodoni, C., Squarcina, P., Tortoreto, M., Villa, A., Vergani, B., Bürdek, M., Botti, L., Arioli, I., Cova, A., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-2170 · Cited by 189 · see citing works

Targeted cancer therapy using engineered exosome as a natural drug delivery vehicle

Gomari, H., Moghadam, M. F., & Soleimani, M. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s173110 · Cited by 189 · see citing works

Designer Exosomes for Active Targeted Chemo‐Photothermal Synergistic Tumor Therapy

Wang, J., Dong, Y., Li, Y., Li, W., Cheng, K., Qian, Y., Xu, G., Zhang, X., Hu, L., Chen, P., et al. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201707360 · Cited by 188 · see citing works

Exosomes as nanocarriers for immunotherapy of cancer and inflammatory diseases

Tran, T.-H., Mattheolabakis, G., Aldawsari, H. M., & Amiji, M. M. (2015) · Clinical Immunology · doi:10.1016/j.clim.2015.03.021 · Cited by 186 · see citing works

Extracellular vesicles induce minimal hepatotoxicity and immunogenicity

Saleh, A. F. A., Lázaro‐Ibáñez, E., Forsgard, M., Shatnyeva, O., Osteikoetxea, X., Karlsson, F. H., Heath, N., Ingelsten, M., Rose, J., Harris, J., et al. (2019) · Nanoscale · doi:10.1039/c8nr08720b · Cited by 185 · see citing works

Recent Advances in Exosome-Based Drug Delivery for Cancer Therapy

Kim, H., Jang, H., Cho, H., Choi, J., Hwang, K. Y., Choi, Y., Kim, S. H., & Yang, Y. (2021) · Cancers · doi:10.3390/cancers13174435 · Cited by 152 · see citing works

Exploitation of Exosomes as Nanocarriers for Gene-, Chemo-, and Immune-Therapy of Cancer

Srivastava, A., Babu, A., Filant, J., Moxley, K., Ruskin, R., Dhanasekaran, D. N., Sood, A., McMeekin, S., & Ramesh, R. (2016) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2016.2205 · Cited by 96 · see citing works

New advances in exosome-based targeted drug delivery systems

Ferreira, D., Moreira, J. N., & Rodrigues, L. R. (2022) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2022.103628 · Cited by 176 · see citing works

Exosomes: Cell-Derived Nanoplatforms for the Delivery of Cancer Therapeutics

Kim, H., Kim, E. H., Kwak, G., Chi, S.-G., Kim, S. H., & Yang, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010014 · Cited by 147 · see citing works

Exosomes as Precision Nanocarriers: A Next-generation Approach to Targeted Cancer Therapy

Kumar, P., Diksha, Gautam, S., Zafar, M., Hussain, Z., & Verma, N. (2026) · Current Materials Science · doi:10.2174/0126661454435402260330092224