The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Pathogenesis of cerebral white matter injury of prematurity
Open accessAbstract
Cerebral white matter injury, characterised by loss of premyelinating oligodendrocytes (pre-OLs), is the most common form of injury to the preterm brain and is associated with a high risk of neurodevelopmental impairment. The unique cerebrovascular anatomy and physiology of the premature baby underlies the exquisite sensitivity of white matter to the abnormal milieu of preterm extrauterine life, in particular ischaemia and inflammation. These two upstream mechanisms can coexist and amplify their effects, leading to activation of two principal downstream mechanisms: excitotoxicity and free radical attack. Upstream mechanisms trigger generation of reactive oxygen and nitrogen species. The pre-OL is intrinsically vulnerable to free radical attack due to immaturity of antioxidant enzyme systems and iron accumulation. Ischaemia and inflammation trigger glutamate receptor-mediated injury leading to maturation-dependent cell death and loss of cellular processes. This review looks at recent evidence for pathogenetic mechanisms in white matter injury with emphasis on targets for prevention and treatment of injury.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Lehnardt, S., Massillon, L., Follett, P., Jensen, F. E., Ratan, R., Rosenberg, P. A., Volpe, J. J., & Vartanian, T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432609100 · Cited by 1,052
Self-citationBack, S. A., Gan, X., Li, Y., Rosenberg, P. A., & Volpe, J. J. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-16-06241.1998 · Cited by 586
Self-citationInder, T., Mocatta, T., Darlow, B., Spencer, C., Volpe, J. J., & Winterbourn, C. (2002) · Pediatric Research · doi:10.1203/00006450-200208000-00013 · Cited by 125
Self-citation
Cited by
Cerebellum of the Premature Infant: Rapidly Developing, Vulnerable, Clinically Important
Volpe, J. J. (2009) · Journal of Child Neurology · doi:10.1177/0883073809338067 · Cited by 503
Self-citationAxin2 as regulatory and therapeutic target in newborn brain injury and remyelination
Fancy, S. P. J., Harrington, E. P., Yuen, T. J., Silbereis, J. C., Zhao, C., Baranzini, S. E., Bruce, C. C., Otero, J. J., Huang, E. J., Nusse, R., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2855 · Cited by 349
“Hypoxic ischemic encephalopathy (HIE) causes neuronal apoptosis as well as diffuse primary damage to subcortical white matter in the term infant brain, whereas periventricular leukomalacia (PVL) comprises focal injury to white matter tracts as well as diffuse gliotic lesions, typically in premature infant”
BackgroundHOON JR, A. H., STASHINKO, E. E., NAGAE, L. M., LIN, D. D., KELLER, J., BASTIAN, A., CAMPBELL, M. L., LEVEY, E., MORI, S., & JOHNSTON, M. V. (2009) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.2009.03306.x · Cited by 321
The Consequences of Chorioamnionitis: Preterm Birth and Effects on Development
Galinsky, R., Polglase, G. R., Hooper, S. B., Black, M. J., & Moss, T. J. M. (2013) · Journal of Pregnancy · doi:10.1155/2013/412831 · Cited by 280
Infection-induced inflammation and cerebral injury in preterm infants
Strunk, T., Inder, T., Wang, X., Burgner, D., Mallard, C., & Levy, O. (2014) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(14)70710-8 · Cited by 269
Metadata
- Authors
- Khwaja, O., & Volpe, J. J.
- Venue
- Archives of Disease in Childhood - Fetal and Neonatal Edition
- Publisher
- BMJ
- Published
- 2008-02-22
- Volume
- 93
- Issue
- 2
- Pages
- F153-F161
- ISSN
- 1359-2998 (ISSN-L)
- 1468-2052
- OpenAlex
- W2135776201
- Cited by
- 671
- References
- 3
- FWCI
- 34.47
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Pathogenesis of cerebral white matter injury of prematurity. https://app.cochat.ai/papers/10.1136/adc.2006.108837
- The paper
- Khwaja, O., & Volpe, J. J. (2008). Pathogenesis of cerebral white matter injury of prematurity. Archives of Disease in Childhood - Fetal and Neonatal Edition. https://doi.org/10.1136/adc.2006.108837
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
