Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination

Multiple sclerosis

Compston, A., & Coles, A. J. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61620-7 · Cited by 4,459 · see citing works

Functional interaction of β-catenin with the transcription factor LEF-1

Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912 · see citing works

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Huang, S.-M. A., Mishina, Y., Liu, S.-M., Cheung, A. K., Stegmeier, F., Michaud, G., Charlat, O., Wiellette, E., Zhang, Y., Wiessner, S., et al. (2009) · Nature · doi:10.1038/nature08356 · Cited by 2,077 · see citing works

XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

Molenaar, M., van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O., & Clevers, H. (1996) · Cell · doi:10.1016/s0092-8674(00)80112-9 · Cited by 1,824 · see citing works

Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway

Jho, E., Zhang, T., Domon–Dell, C., Joo, C., Freund, J., & Costantini, F. D. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.4.1172-1183.2002 · Cited by 1,683 · see citing works

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

Lock, C., Hermans, G., Pedotti, R., Brendolan, A., Schadt, E. E., Garren, H., Langer-Gould, A. M., Strober, S., Cannella, B., Allard, J. D., et al. (2002) · Nature Medicine · doi:10.1038/nm0502-500 · Cited by 1,659 · see citing works

Remyelination in the CNS: from biology to therapy

Franklin, R. J. M., & ffrench-Constant, C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2480 · Cited by 1,544 · see citing works

Neonatal MRI to Predict Neurodevelopmental Outcomes in Preterm Infants

Woodward, L. J., Anderson, P. J., Austin, N. C., Howard, K., & Inder, T. E. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa053792 · Cited by 1,344 · see citing works

Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

Behrens, J., Jerchow, B., Würtele, M., Grimm, J., Asbrand, C., Wirtz, R. M., Kühl, M., Wedlich, D., & Birchmeier, W. (1998) · Science · doi:10.1126/science.280.5363.596 · Cited by 1,255 · see citing works

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK‐3β and β‐catenin and promotes GSK‐3β‐dependent phosphorylation of β‐catenin

Ikeda, S., Kishida, S., Yamamoto, H., Murai, H., Koyama, S., & Kikuchi, A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.5.1371 · Cited by 1,248 · see citing works

Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors

Lustig, B., Jerchow, B., Sachs, M., Weiler, S., Pietsch, T., Karsten, U., van de Wetering, M., Clevers, H., Schlag, P., Birchmeier, W., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.4.1184-1193.2002 · Cited by 1,198 · see citing works

Intestinal polyposis in mice with a dominant stable mutation of the β‐catenin gene

Harada, N., Tamai, Y., Ishikawa, T., Sauer, B., Takaku, K., Oshima, M., & Taketo, M. M. (1999) · The EMBO Journal · doi:10.1093/emboj/18.21.5931 · Cited by 1,198 · see citing works

Premyelinating Oligodendrocytes in Chronic Lesions of Multiple Sclerosis

Chang, A., Tourtellotte, W. W., Rudick, R., & Trapp, B. D. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa010994 · Cited by 991 · see citing works

Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis

Kuhlmann, T., Miron, V., Cuo, Q., Wegner, C., Antel, J., & Bruck, W. (2008) · Brain · doi:10.1093/brain/awn096 · Cited by 864 · see citing works

Selective Vulnerability of Late Oligodendrocyte Progenitors to Hypoxia–Ischemia

Back, S. A., Han, B. H., Luo, N. L., Chricton, C. A., Xanthoudakis, S., Tam, J., Arvin, K. L., & Holtzman, D. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-02-00455.2002 · Cited by 795 · see citing works

NMDA receptors are expressed in oligodendrocytes and activated in ischaemia

Káradóttir, R. T., Cavelier, P., Bergersen, L. H., & Attwell, D. (2005) · Nature · doi:10.1038/nature04302 · Cited by 773 · see citing works

Myelin Impairs CNS Remyelination by Inhibiting Oligodendrocyte Precursor Cell Differentiation

Kotter, M. R., Li, W.-W., Zhao, C., & Franklin, R. J. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2615-05.2006 · Cited by 768 · see citing works

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

Dessaud, É., McMahon, A. P., & Briscoe, J. (2008) · Development · doi:10.1242/dev.009324 · Cited by 735 · see citing works

Pathogenesis of cerebral white matter injury of prematurity

Khwaja, O., & Volpe, J. J. (2008) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/adc.2006.108837 · Cited by 673 · see citing works

Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Hedgehog-induced medulloblastoma

Schüller, U., Heine, V., Mao, J., Kho, A., Dillon, A. K., Han, Y.-G., Huillard, E., Sun, T., Ligon, A., Qian, Y., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.07.005 · Cited by 656 · see citing works

Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNSPreprint

Fancy, S. P. J., Baranzini, S. E., Zhao, C., Yuk, D., Irvine, K., Kaing, S., Sanai, N., Franklin, R. J. M., & Rowitch, D. H. (2009) · Genes & Development · doi:10.1101/gad.1806309 · Cited by 639 · see citing works

LINGO-1 negatively regulates myelination by oligodendrocytes

Mi, S., Miller, R. H., Lee, X., Scott, M. L., Shulag-Morskaya, S., Shao, Z., Chang, J., Thill, G., Levesque, M., Zhang, M., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1460 · Cited by 628 · see citing works

Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination

Emery, B., Agalliu, D., Cahoy, J. D., Watkins, T. A., Dugas, J. C., Mulinyawe, S. B., Ibrahim, A., Ligon, K. L., Rowitch, D. H., & Barres, B. A. (2009) · Cell · doi:10.1016/j.cell.2009.04.031 · Cited by 559 · see citing works

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction

Ye, F., Chen, Y., Hoang, T., Montgomery, R. L., Zhao, X.-H., Bu, H., Hu, T., Taketo, M. M., van Es, J. H., Clevers, H., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2333 · Cited by 559 · see citing works

Retinoid X receptor gamma signaling accelerates CNS remyelination

Huang, J. K., Jarjour, A. A., Nait Oumesmar, B., Kerninon, C., Williams, A., Krezel, W., Kagechika, H., Bauer, J., Zhao, C., Evercooren, A. B.-V., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2702 · Cited by 547 · see citing works

bHLH Transcription Factor Olig1 Is Required to Repair Demyelinated Lesions in the CNS

Arnett, H. A., Fancy, S. P. J., Alberta, J. A., Zhao, C., Plant, S. R., Kaing, S., Raine, C. S., Rowitch, D. H., Franklin, R. J. M., & Stiles, C. D. (2004) · Science · doi:10.1126/science.1103709 · Cited by 416 · see citing works

Wnt Proteins Are Self-Renewal Factors for Mammary Stem Cells and Promote Their Long-Term Expansion in Culture

Zeng, Y. A., & Nusse, R. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.03.020 · Cited by 398 · see citing works

Arrested oligodendrocyte lineage maturation in chronic perinatal white matter injury

Segovia, K. N., McClure, M., Moravec, M., Luo, N. L., Wan, Y., Gong, X., Riddle, A., Craig, A., Struve, J., Sherman, L. S., et al. (2008) · Annals of Neurology · doi:10.1002/ana.21359 · Cited by 340 · see citing works

Distinct Stages of Myelination Regulated by γ-Secretase and Astrocytes in a Rapidly Myelinating CNS Coculture System

Watkins, T. A., Emery, B., Mulinyawe, S. B., & Barres, B. A. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.011 · Cited by 317 · see citing works

RESEARCH ARTICLE: Myelin Abnormalities without Oligodendrocyte Loss in Periventricular Leukomalacia

Billiards, S., Haynes, R., Folkerth, R., Borenstein, N. S., Trachtenberg, F., Rowitch, D., Ligon, K., Volpe, J., & Kinney, H. C. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00107.x · Cited by 257 · see citing works

Extensive remyelination of the CNS leads to functional recovery

Duncan, I. D., Brower, A., Kondo, Y., Curlee, J. F., & Schultz, R. D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812500106 · Cited by 227 · see citing works

Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination

Zhang, Y., Argaw, A. T., Gurfein, B. T., Zameer, A., Snyder, B. J., Ge, C., Lu, Q. R., Rowitch, D. H., Raine, C. S., Brosnan, C. F., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902834106 · Cited by 210 · see citing works

Lysolecithin induces demyelination in vitro in a cerebellar slice culture system

Birgbauer, E., Rao, T. S., & Webb, M. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20248 · Cited by 190 · see citing works

Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination

Harrington, E. P., Zhao, C., Fancy, S. P. J., Kaing, S., Franklin, R. J. M., & Rowitch, D. H. (2010) · Annals of Neurology · doi:10.1002/ana.22090 · Cited by 159 · see citing works

Wnt signaling is sufficient to perturb oligodendrocyte maturation

Feigenson, K. A., Reid, M., See, J. M., Crenshaw, E. B., & Grinspan, J. B. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.07.010 · Cited by 157 · see citing works

Towards improved animal models of neonatal white matter injury associated with cerebral palsy

Silbereis, J. C., Huang, E. J., Back, S. A., & Rowitch, D. H. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.002915 · Cited by 116 · see citing works

Axin2 regulates chondrocyte maturation and axial skeletal development

Dao, D. Y., Yang, X. L., Flick, L. M., Chen, D., Hilton, M. J., & O’Keefe, R. J. (2009) · Journal of Orthopaedic Research® · doi:10.1002/jor.20954 · Cited by 44 · see citing works

The Pathobiology of Vascular Dementia

Iadecola, C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.008 · Cited by 1,857 · see citing works

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

Miron, V. E., Boyd, A., Zhao, J.-W., Yuen, T. J., Ruckh, J. M., Shadrach, J. L., van Wijngaarden, P., Wagers, A. J., Williams, A., Franklin, R. J. M., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3469 · Cited by 1,788 · see citing works

Can we safely target the WNT pathway?

Kahn, M. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4233 · Cited by 1,039 · see citing works

Regenerating CNS myelin — from mechanisms to experimental medicines

Franklin, R. J. M., & ffrench-Constant, C. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.136 · Cited by 647 · see citing works

Oligodendrocytes in development, myelin generation and beyond

Kuhn, S., Gritti, L., Crooks, D., & Dombrowski, Y. (2019) · Cells · doi:10.3390/cells8111424 · Cited by 625 · see citing works

Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis

Mei, F., Fancy, S. P. J., Shen, Y. A., Niu, J., Zhao, C., Presley, B., Miao, E., Lee, S., Mayoral, S. R., Redmond, S., et al. (2014) · Nature Medicine · doi:10.1038/nm.3618 · Cited by 595 · see citing works

Wnt signaling in stem and cancer stem cells

Holland, J. D., Klaus‐Bergmann, A., Garratt, A. N., & Birchmeier, W. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2013.01.004 · Cited by 504 · see citing works

White matter injury in the preterm infant: pathology and mechanisms

Back, S. A. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1718-6 · Cited by 510 · see citing works

Oligodendrocyte precursors migrate along vasculature in the developing nervous system

Tsai, H.-H., Niu, J., Munji, R., Davalos, D., Chang, J., Zhang, H., Tien, A.-C., Kuo, C. J., Chan, J. R., Daneman, R., et al. (2016) · Science · doi:10.1126/science.aad3839 · Cited by 483 · see citing works

Arrested preoligodendrocyte maturation contributes to myelination failure in premature infants

Buser, J. R., Maire, J. J., Riddle, A., Gong, X., Nguyen, T. D., Nelson, K., Luo, N. L., Ren, J., Struve, J. N., Sherman, L. S., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22627 · Cited by 447 · see citing works

Oligodendrocyte-Encoded HIF Function Couples Postnatal Myelination and White Matter Angiogenesis

Yuen, T. J., Silbereis, J. C., Griveau, A., Chang, S. M., Daneman, R., Fancy, S. P. J., Zahed, H., Maltepe, E., & Rowitch, D. H. (2014) · Cell · doi:10.1016/j.cell.2014.04.052 · Cited by 433 · see citing works

Brain injury in premature neonates: A primary cerebral dysmaturation disorder?

Back, S. A., & Miller, S. P. (2014) · Annals of Neurology · doi:10.1002/ana.24132 · Cited by 360 · see citing works

Tertiary mechanisms of brain damage: a new hope for treatment of cerebral palsy?

Fleiss, B., & Gressèns, P. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70058-3 · Cited by 367 · see citing works

Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery

Mei, F., Lehmann‐Horn, K., Shen, Y. A., Rankin, K. A., Stebbins, K. J., Lorrain, D. S., Pekarek, K. L., Sagan, S. A., Xiao, L., Teuscher, C., et al. (2016) · eLife · doi:10.7554/elife.18246 · Cited by 323 · see citing works

Origin and dynamics of oligodendrocytes in the developing brain: Implications for perinatal white matter injury

van Tilborg, E., de Theije, C. G. M., van Hal, M., Wagenaar, N., de Vries, L. S., Benders, M. J. N. L., Rowitch, D. H., & Nijboer, C. H. A. (2017) · Glia · doi:10.1002/glia.23256 · Cited by 292 · see citing works

Demyelination Causes Adult CNS Progenitors to Revert to an Immature State and Express Immune Cues That Support Their Migration

Moyon, S., Dubessy, A., Aigrot, M. S., Trotter, M. W. B., Huang, J. K., Dauphinot, L., Potier, M., Kerninon, C., Parsadaniantz, S. M., Franklin, R. J. M., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0849-14.2015 · Cited by 295 · see citing works

Insufficient OPC migration into demyelinated lesions is a cause of poor remyelination in MS and mouse models

Boyd, A. L., Zhang, H., & Williams, A. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1112-y · Cited by 284 · see citing works

Tankyrase-targeted therapeutics: expanding opportunities in the PARP family

Riffell, J. L., Lord, C. J., & Ashworth, A. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3868 · Cited by 290 · see citing works

Remyelination therapies: a new direction and challenge in multiple sclerosis

Plemel, J. R., Liu, W., & Yong, V. W. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.115 · Cited by 281 · see citing works

Neuroprotection and repair in multiple sclerosis

Franklin, R. J. M., ffrench‐Constant, C., Edgar, J. M., & Smith, K. J. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.200 · Cited by 274 · see citing works

Neurobiology of premature brain injury

Salmaso, N., Jablonska, B., Scafidi, J., Vaccarino, F. M., & Gallo, V. (2014) · Nature Neuroscience · doi:10.1038/nn.3604 · Cited by 271 · see citing works

A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment

Griveau, A., Seano, G., Shelton, S. J., Kupp, R., Jahangiri, A., Obernier, K., Krishnan, S., Lindberg, O. R., Yuen, T. J., Tien, A., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.020 · Cited by 254 · see citing works

Actin filament turnover drives leading edge growth during myelin sheath formation in the central nervous system

Nawaz, S., Sánchez, P., Schmitt, S., Snaidero, N., Mitkovski, M., Velte, C., Brückner, B., Alexopoulos, I., Czopka, T., Jung, S. Y., et al. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.05.013 · Cited by 214 · see citing works

Wnt/Catenin Signaling in Adult Stem Cell Physiology and Disease

Ring, A., Kim, Y., & Kahn, M. (2014) · Stem Cell Reviews and Reports · doi:10.1007/s12015-014-9515-2 · Cited by 240 · see citing works

How to make an oligodendrocyte

Goldman, S. A., & Kuypers, N. J. (2015) · Development · doi:10.1242/dev.126409 · Cited by 226 · see citing works

Glial Development: The Crossroads of Regeneration and Repair in the CNS

Gallo, V., & Deneen, B. (2014) · Neuron · doi:10.1016/j.neuron.2014.06.010 · Cited by 219 · see citing works

Intracellular signaling pathway regulation of myelination and remyelination in the CNS

Gaesser, J. M., & Fyffe-Maricich, S. L. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.03.008 · Cited by 208 · see citing works

Glia Disease and Repair—RemyelinationPreprint

Franklin, R. J. M., & Goldman, S. A. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020594 · Cited by 208 · see citing works

Astrocyte-derived endothelin-1 inhibits remyelination through notch activation

Hammond, T. R., Gadea, A., Dupree, J., Kerninon, C., Nait-Oumesmar, B., Aguirre, A., & Gallo, V. (2014) · Neuron · doi:10.1016/j.neuron.2013.11.015 · Cited by 206 · see citing works

Mechanisms of lysophosphatidylcholine‐induced demyelination: A primary lipid disrupting myelinopathy

Plemel, J. R., Michaels, N. J., Weishaupt, N., Caprariello, A. V., Keough, M. B., Rogers, J. A., Yukseloglu, A., Lim, J., Patel, V. V., Rawji, K. S., et al. (2018) · Glia · doi:10.1002/glia.23245 · Cited by 220 · see citing works

The impact of cerebrovascular aging on vascular cognitive impairment and dementia

Yang, T., Sun, Y., Lu, Z., Leak, R. K., & Zhang, F. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.007 · Cited by 206 · see citing works

Enhancing Oligodendrocyte Myelination Rescues Synaptic Loss and Improves Functional Recovery after Chronic Hypoxia

Wang, F., Yang, Y., Yang, N., Chen, X., Huang, N.-X., Zhang, J., Wu, Y., Liu, Z., Gao, X., Li, T., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.017 · Cited by 201 · see citing works

Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage

Petersen, M. A., Ryu, J. K., Chang, K.-J., Etxeberría, A., Bardehle, S., Mendiola, A. S., Kamau-Devers, W., Fancy, S. P. J., Thor, A., Bushong, E. A., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.10.008 · Cited by 198 · see citing works

Pathophysiology of glia in perinatal white matter injury

Back, S. A., & Rosenberg, P. A. (2014) · Glia · doi:10.1002/glia.22658 · Cited by 202 · see citing works

Remyelination after spinal cord injury: Is it a target for repair?

Plemel, J. R., Keough, M. B., Duncan, G. J., Sparling, J. S., Yong, V. W., Stys, P. K., & Tetzlaff, W. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.02.006 · Cited by 197 · see citing works

Modulation of oligodendrocyte generation during a critical temporal window after NG2 cell division

Hill, R., Patel, K. D., Gonçalves, C. M., Grutzendler, J., & Nishiyama, A. (2014) · Nature Neuroscience · doi:10.1038/nn.3815 · Cited by 186 · see citing works

Cholesterol in myelin biogenesis and hypomyelinating disorders

Saher, G., & Stumpf, S. K. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2015.02.010 · Cited by 192 · see citing works

Mammalian Target of Rapamycin Promotes Oligodendrocyte Differentiation, Initiation and Extent of CNS Myelination

Wahl, S., McLane, L. E., Bercury, K. K., Macklin, W. B., & Wood, T. L. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4311-13.2014 · Cited by 178 · see citing works

CNS myelination and remyelination depend on fatty acid synthesis by oligodendrocytes

Dimas, P., Montani, L., Pereira, J. A., Moreno, D., Trötzmüller, M., Gerber, J., Semenkovich, C. F., Köfeler, H. C., & Suter, U. (2019) · eLife · doi:10.7554/elife.44702 · Cited by 178 · see citing works

Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2

Meijer, D. H., Kane, M., Mehta, S. V., Liu, H., Harrington, E., Taylor, C. M., Stiles, C. D., & Rowitch, D. H. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3386 · Cited by 171 · see citing works

Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation

Zhao, C., Deng, Y., Liu, L., Yu, K., Zhang, L., Wang, H., He, X., Wang, J., Lu, C., Wu, L. N., et al. (2016) · Nature Communications · doi:10.1038/ncomms10883 · Cited by 154 · see citing works

Inhibition of Tankyrases Induces Axin Stabilization and Blocks Wnt Signalling in Breast Cancer Cells

Bao, R.-Y., Christova, T. Y., Song, S., Angers, S., Yan, X., & Attisano, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048670 · Cited by 161 · see citing works

Microglia mediated neuroinflammation in neurodegenerative diseases: A review on the cell signaling pathways involved in microglial activation

Biswas, K. (2023) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2023.578180 · Cited by 159 · see citing works

Current and Emerging Therapies in the Management of Hypoxic Ischemic Encephalopathy in Neonates

Nair, J., & Kumar, V. (2018) · Children · doi:10.3390/children5070099 · Cited by 157 · see citing works

Impaired oligodendrocyte maturation in preterm infants: Potential therapeutic targets

van Tilborg, E., Heijnen, C. J., Benders, M. J. N. L., van Bel, F., Fleiss, B., Gressèns, P., & Nijboer, C. H. A. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.11.002 · Cited by 148 · see citing works

Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain

Steenwinckel, J. V., Schang, A., Krishnan, M. L., Degos, V., Delahaye‐Duriez, A., Bokobza, C., Csaba, Z., Verdonk, F., Montané, A., Sigaut, S., et al. (2019) · Brain · doi:10.1093/brain/awz319 · Cited by 150 · see citing works

Myelin loss and oligodendrocyte pathology in white matter tracts following traumatic brain injury in the rat

Flygt, J., Djupsjö, A., Lenne, F., & Marklund, N. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12179 · Cited by 144 · see citing works

Glial Cell Development and Function in ZebrafishPreprint

Lyons, D. A., & Talbot, W. S. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020586 · Cited by 143 · see citing works

Reactive astrocyte COX2-PGE2 production inhibits oligodendrocyte maturation in neonatal white matter injury

Shiow, L. R., Favrais, G., Schirmer, L., Schang, A., Cipriani, S., Andres, C., Wright, J. N., Nobuta, H., Fleiss, B., Gressens, P., et al. (2017) · Glia · doi:10.1002/glia.23212 · Cited by 130 · see citing works

Mechanisms of Perinatal Arterial Ischemic Stroke

Fernández‐López, D., Natarajan, N., Ashwal, S., & Vexler, Z. S. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.41 · Cited by 132 · see citing works

Clemastine rescues myelination defects and promotes functional recovery in hypoxic brain injury

Cree, B., Niu, J., Hoi, K. K., Zhao, C., Caganap, S. D., Henry, R. G., Dao, D. Q., Zollinger, D. R., Mei, F., Shen, Y. A., et al. (2017) · Brain · doi:10.1093/brain/awx312 · Cited by 127 · see citing works

Sonic Hedgehog Signaling Is a Positive Oligodendrocyte Regulator during Demyelination

Ferent, J., Zimmer, C., Durbec, P. L., Ruat, M., & Traiffort, É. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3334-12.2013 · Cited by 126 · see citing works

Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination

Mei, F., Mayoral, S. R., Nobuta, H., Wang, F., Desponts, C., Lorrain, D. S., Xiao, L., Green, A., Rowitch, D. H., Whistler, J. L., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1493-16.2016 · Cited by 124 · see citing works

Identification of NVP-TNKS656: The Use of Structure–Efficiency Relationships To Generate a Highly Potent, Selective, and Orally Active Tankyrase Inhibitor

Shultz, M. D., Cheung, A. K., Kirby, C. A., Firestone, B., Fan, J., Chen, C. H.-T., Chen, Z., Chin, D. N., DiPietro, L., Fazal, A., et al. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm400807n · Cited by 118 · see citing works

Role of Wnt Signaling in Central Nervous System Injury

Lambert, C., Cisternas, P., & Inestrosa, N. C. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9138-x · Cited by 118 · see citing works

MiR-19b/20a/92a regulates the self-renewal and proliferation of gastric cancer stem cells

Wu, Q., Yang, Z., Wang, F., Hu, S., Li, Y., Shi, Y., & Fan, D. (2013) · Journal of Cell Science · doi:10.1242/jcs.127944 · Cited by 116 · see citing works

Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer

Fancy, S. P. J., Harrington, E. P., Baranzini, S. E., Silbereis, J. C., Shiow, L. R., Yuen, T. J., Huang, E. J., Lomvardas, S., & Rowitch, D. H. (2014) · Nature Neuroscience · doi:10.1038/nn.3676 · Cited by 115 · see citing works

Myelin regulatory factor drives remyelination in multiple sclerosis

Duncan, G. J., Plemel, J. R., Assinck, P., Manesh, S. B., Muir, F. G. W., Hirata, R., Berson, M., Liu, J., Wegner, M., Emery, B., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1741-7 · Cited by 115 · see citing works

Stage-Specific Regulation of Oligodendrocyte Development by Wnt/ -Catenin Signaling

Dai, Z., Sun, S., Wang, C., Huang, H., Hu, X., Zhang, Z., Lu, Q. R., & Qiu, M. S. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0311-14.2014 · Cited by 114 · see citing works

Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination

Redmond, S., Mei, F., Eshed‐Eisenbach, Y., Osso, L. A., Leshkowitz, D., Shen, Y. A., Kay, J. N., Aurrand‐Lions, M., Lyons, D. A., Peles, E., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.07.021 · Cited by 106 · see citing works

Achievements and obstacles of remyelinating therapies in multiple sclerosis

Stangel, M., Kuhlmann, T., Matthews, P. M., & Kilpatrick, T. J. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.139 · Cited by 109 · see citing works

Brain Injury in the Preterm Infant: New Horizons for Pathogenesis and Prevention

Back, S. A. (2015) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2015.04.006 · Cited by 109 · see citing works

Canonical Wnt signaling in the oligodendroglial lineage-puzzles remain

Guo, F., Lang, J., Sohn, J., Hammond, E., Chang, M., & Pleasure, D. (2015) · Glia · doi:10.1002/glia.22813 · Cited by 107 · see citing works

ADP-ribosylation signalling and human disease

Palazzo, L., Mikolčević, P., Mikoč, A., & Ahel, I. (2019) · Open Biology · doi:10.1098/rsob.190041 · Cited by 104 · see citing works

Myelin inhibits oligodendroglial maturation and regulates oligodendrocytic transcription factor expression

Plemel, J. R., Manesh, S. B., Sparling, J. S., & Tetzlaff, W. (2013) · Glia · doi:10.1002/glia.22535 · Cited by 107 · see citing works

Optic neuritis in neuromyelitis optica

Levin, M. H., Bennett, J. L., & Verkman, A. S. (2013) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2013.03.001 · Cited by 103 · see citing works

Axonal selection and myelin sheath generation in the central nervous system

Simons, M., & Lyons, D. A. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2013.04.007 · Cited by 102 · see citing works

Adenomatous Polyposis Coli Regulates Oligodendroglial Development

Lang, J., Maeda, Y., Bannerman, P. G. C., Xu, J., Horiuchi, M., Pleasure, D., & Guo, F. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3467-12.2013 · Cited by 102 · see citing works

Prolonged myelin deficits contribute to neuron loss and functional impairments after ischaemic stroke

Cheng, Y.-J., Wang, F., Feng, J., Yu, B., Wang, B., Gao, Q. C., Wang, T.-Y., Hu, B., Gao, X., Chen, J., et al. (2024) · Brain · doi:10.1093/brain/awae029 · Cited by 102 · see citing works

Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment

Morrone, S. R., Cheng, Z., Moon, R. T., Cong, F., & Xu, W. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116618109 · Cited by 100 · see citing works

Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity

Schirmer, L., Möbius, W., Zhao, C., Cruz-Herranz, A., Haim, L. B., Cordano, C., Shiow, L. R., Kelley, K. W., Sadowski, B., Timmons, G. M., et al. (2018) · eLife · doi:10.7554/elife.36428 · Cited by 100 · see citing works

Preterm brain Injury: White matter injury

Schneider, J., & Miller, S. P. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64029-1.00007-2 · Cited by 102 · see citing works

Wnt-Dependent Oligodendroglial-Endothelial Interactions Regulate White Matter Vascularization and Attenuate Injury

Chavali, M., Ulloa-Navas, M. J., Pérez-Borredá, P., García‐Verdugo, J. M., McQuillen, P. S., Huang, E. J., & Rowitch, D. H. (2020) · Neuron · doi:10.1016/j.neuron.2020.09.033 · Cited by 99 · see citing works

Cerebral White and Gray Matter Injury in Newborns

Back, S. A. (2014) · Clinics in Perinatology · doi:10.1016/j.clp.2013.11.001 · Cited by 97 · see citing works

Wnt Signaling in the Pathogenesis of Multiple Sclerosis-Associated Chronic Pain

Yuan, S., Shi, Y., & Tang, S. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9370-3 · Cited by 95 · see citing works

Blood RNA profiling in a large cohort of multiple sclerosis patients and healthy controls

Nickles, D., Chen, H. P., Li, M. M., Khankhanian, P., Madireddy, L., Caillier, S. J., Santaniello, A., Cree, B., Pelletier, D., Hauser, S. L., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt267 · Cited by 92 · see citing works

Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury

Jablonska, B., Gierdalski, M., Chew, L., Hawley, T. S., Catron, M. A., Lichauco, A. M., Cabrera‐Luque, J., Yuen, T. J., Rowitch, D. H., & Gallo, V. (2016) · Nature Communications · doi:10.1038/ncomms13866 · Cited by 94 · see citing works

Wnt Acts as a Prosurvival Signal to Enhance Dentin Regeneration

Hunter, D. J., Bardet, C., Mouraret, S., Liu, B., Singh, G., Sadoine, J., Dhamdhere, G. R., Smith, A., Tran, X. V., Joy, A., et al. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2444 · Cited by 93 · see citing works

Pushing Forward: Remyelination as the New Frontier in CNS Diseases

Kremer, D., Göttle, P., Hartung, H., & Küry, P. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.02.004 · Cited by 89 · see citing works

The Wnt Effector Transcription Factor 7-Like 2 Positively Regulates Oligodendrocyte Differentiation in a Manner Independent of Wnt/β-Catenin Signaling

Hammond, E., Lang, J., Maeda, Y., Pleasure, D., Angus-Hill, M. L., Xu, J., Horiuchi, M., Deng, W., & Guo, F. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4787-14.2015 · Cited by 91 · see citing works

Daam2-PIP5K Is a Regulatory Pathway for Wnt Signaling and Therapeutic Target for Remyelination in the CNS

Lee, H. K., Chaboub, L. S., Zhu, W., Zollinger, D. R., Rasband, M. N., Fancy, S. P. J., & Deneen, B. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.024 · Cited by 89 · see citing works

Oligodendrocyte regeneration: Its significance in myelin replacement and neuroprotection in multiple sclerosis

Chamberlain, K. A., Nanescu, S. E., Psachoulia, K., & Huang, J. K. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.10.010 · Cited by 88 · see citing works

Interactions Between the Canonical WNT/Beta-Catenin Pathway and PPAR Gamma on Neuroinflammation, Demyelination, and Remyelination in Multiple Sclerosis

Vallée, A., Vallée, J.-N., Guillevin, R., & Lecarpentier, Y. (2017) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0550-9 · Cited by 84 · see citing works

Coordinated control of oligodendrocyte development by extrinsic and intrinsic signaling cues

He, L., & Lu, Q. R. (2013) · Neuroscience Bulletin · doi:10.1007/s12264-013-1318-y · Cited by 82 · see citing works

Pathological potential of oligodendrocyte precursor cells: terra incognita

Yi, C., Verkhratsky, A., & Niu, J. (2023) · Trends in Neurosciences · doi:10.1016/j.tins.2023.04.003 · Cited by 81 · see citing works

Tamoxifen accelerates the repair of demyelinated lesions in the central nervous system

Gonzalez, G. A., Hofer, M. P., Syed, Y. A., Amaral, A. I., Rundle, J., Rahman, S., Zhao, C., & Kotter, M. R. N. (2016) · Scientific Reports · doi:10.1038/srep31599 · Cited by 82 · see citing works

Remyelination Therapy in Multiple Sclerosis

Harlow, D. E., Honce, J. M., & Miravalle, A. A. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00257 · Cited by 84 · see citing works

Neuroprotective and regenerative roles of intranasal Wnt-3a administration after focal ischemic stroke in mice

Wei, Z. Z., Zhang, J. Y., Taylor, T. M., Gu, X., Zhao, Y., & Wei, L. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17702669 · Cited by 82 · see citing works

Identification of endothelin 2 as an inflammatory factor that promotes central nervous system remyelination

Yuen, T. J., Johnson, K. R., Miron, V. E., Zhao, C., Quandt, J., Harrisingh, M. C., Swire, M., Williams, A., McFarland, H. F., Franklin, R. J. M., et al. (2013) · Brain · doi:10.1093/brain/awt024 · Cited by 80 · see citing works

Extracellular cues influencing oligodendrocyte differentiation and (re)myelination

Wheeler, N. A., & Fuss, B. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.03.019 · Cited by 78 · see citing works

Inhibitors of myelination: ECM changes, CSPGs and PTPs

Harlow, D. E., & Macklin, W. B. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.10.017 · Cited by 78 · see citing works

PI3K Signaling and Stat92E Converge to Modulate Glial Responsiveness to Axonal Injury

Doherty, J., Sheehan, A. E., Bradshaw, R., Fox, A. N., Lu, T.-Y., & Freeman, M. R. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001985 · Cited by 77 · see citing works

Anti-Muscarinic Adjunct Therapy Accelerates Functional Human Oligodendrocyte Repair

Abiraman, K., Pol, S. U., O’Bara, M. A., Chen, G., Khaku, Z. M., Wang, J., Thorn, D. A., Vedia, B. H., Ekwegbalu, E. C., Li, J., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3510-14.2015 · Cited by 75 · see citing works

Activin receptors regulate the oligodendrocyte lineage in health and disease

Dillenburg, A., Ireland, G., Holloway, R. K., Davies, C. L., Evans, F. L., Swire, M., Bechler, M. E., Soong, D., Yuen, T. J., Su, G. H., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1813-3 · Cited by 75 · see citing works

Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase

Xu, W., Lau, Y. H., Fischer, G. W., Tan, Y. S., Chattopadhyay, A., de la Roche, M., Hyvönen, M., Verma, C. S., Spring, D. R., & Itzhaki, L. S. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.6b10234 · Cited by 74 · see citing works

Controversies in preterm brain injury

Penn, A. A., Gressèns, P., Fleiss, B., Back, S. A., & Gallo, V. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.10.012 · Cited by 73 · see citing works

Vitamin C promotes oligodendrocytes generation and remyelination

Guo, Y., Suo, N., Cui, X. J., Yuan, Q., & Xie, X. (2018) · Glia · doi:10.1002/glia.23306 · Cited by 73 · see citing works

Motor Behavioral Deficits in the Cuprizone Model: Validity of the Rotarod Test Paradigm

Lubrich, C., Giesler, P., & Kipp, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911342 · Cited by 77 · see citing works

Microglia Diversity in Health and Multiple Sclerosis

Zia, S., Rawji, K. S., Michaels, N. J., Burr, M. K., Kerr, B. J., Healy, L. M., & Plemel, J. R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.588021 · Cited by 69 · see citing works

[1,2,4]Triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: Antagonists of the Wnt Pathway That Inhibit Tankyrases 1 and 2 via Novel Adenosine Pocket Binding

Shultz, M. D., Kirby, C. A., Stams, T., Chin, D. N., Blank, J., Charlat, O., Cheng, H., Cheung, A. K., Cong, F., Feng, Y., et al. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm2011222 · Cited by 69 · see citing works

A common target in MS and neonatal hypoxic brain injury

Kingwell, K. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.113

Anti-TANKyrase weapons promote myelination

Casaccia, P. (2011) · Nature Neuroscience · doi:10.1038/nn.2885 · Cited by 12 · see citing works

Manipulating developmental mechanisms to promote remyelination

Harrington, E. (2012) · eScholarship (California Digital Library)

New roles for old proteins in adult CNS axonal regeneration

Spencer, T. K., Domeniconi, M., Cao, Z., & Filbin, M. T. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00012-6 · Cited by 71 · see citing works

Histamine H2 receptor negatively regulates oligodendrocyte differentiation in neonatal hypoxic-ischemic white matter injury

Jiang, L., Li, C., Chen, H., Dai, H., An, D., Ma, Q., Zheng, Y., Zhang, X., Hu, W., & Chen, Z. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20191365 · Cited by 29 · see citing works