Hypoglycaemia in congenital adrenal hyperplasia
Open accessAbstract
Two young children with salt-losing congenital adrenal hyperplasia developed profound hypoglycaemia. In one child hypoglycaemia occurred after a prolonged fast and in the other it was precipitated by infection. This complication may be more common than the literature suggests, and emergency treatment with glucose or hydrocortisone, given by injection, should be given to any child with the disorder who suddenly or unexpectedly collapses.
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Children with CAH are at greater risk for seizures, cognitive impairment, and increased mortality due to severe hypoglycemia associated with illness.
“Further studies are needed to understand adrenomedullary morphology and function in very young children, especially those with CAH, who are at greater risk for seizures, cognitive impairment (13-15), and increased mortality (16) due to severe hypoglycemia associated with illness.”
From Decreased adrenomedullary function in infants with classical congenital adrenal hyperplasia. (2014) · cites this paper as [14]
The case reports describe profound hypoglycaemia during illness, and the discussion calls hypoglycaemia in children with CAH a 'potentially lethal complication.' That supports a risk of death, but the paper does not establish increased mortality from illness-associated hypoglycaemia. The seizure and cognitive-impairment portions are attached to other citations, not this source. (LLM, conf=0.82)
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Cites
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Hypoglycaemia during illness in children with congenital adrenal hyperplasia
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Stress doses of glucocorticoids cannot prevent progression of all adrenal crises
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- Authors
- Mackinnon, J., & Grant, D. B.
- Affiliations
- Aristotle University of Thessaloniki (GR)
- ORCID
- Grant, D B
- Venue
- Archives of Disease in Childhood
- Publisher
- BMJ
- Published
- 1977-07-01
- Volume
- 52
- Issue
- 7
- Pages
- 591-593
- ISSN
- 0003-9888 (ISSN-L)
- 1468-2044
- PMC
- PMC1544766
- OpenAlex
- W2003046319
- Cited by
- 17
- References
- 4
- Citations by year
- 2023: 1 · 2021: 1 · 2017: 1 · 2014: 1
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Archives of Disease in Childhood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Keywords
- congenital adrenal hyperplasia, hypoglycemia, prolonged fasting, infection, cortisol, glucose therapy, emergency treatment, children
- MeSH terms
- Adrenocortical Hyperfunction, Adrenal Hyperplasia, Congenital, Child, Preschool, Female, Glucose, Humans, Hydrocortisone, Hypoglycemia, Infant, Male
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