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Outbreaks of hand, foot, and mouth disease by enterovirus 71. High incidence of complication disorders of central nervous system.
Open accessAbstract
In Japan we have had two outbreaks of hand, foot, and mouth disease associated with disorders of the central nervous system, one in 1973 and the other in 1978. The isolated virus in both outbreaks was enterovirus 71. Central nervous system disorders were present in 24% of patients in 1973 and in 8% of patients in 1978. These disorders were localised encephalitis with cerebellar signs as the main feature, aseptic meningitis, and polio-like paresis. The enterovirus 71 isolated in Japan had strong dermatotropic as well as neurotropic tendencies. However in cross-neutralisation tests, no difference in antigenicity from the prototype, BrCr strain, was recognised.
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Citations
Cited by
An overview of the evolution of enterovirus 71 and its clinical and public health significance
McMinn, P. C. (2002) · FEMS Microbiology Reviews · doi:10.1016/s0168-6445(02)00070-0 · Cited by 699
Chan, L. G., Parashar, U. D., Lye, M. S., Ong, F. G. L., Zaki, S. R., Alexander, J. P., Ho, K. K., Han, L. L., Pallansch, M. A., Suleiman, A. B., et al. (2000) · Clinical Infectious Diseases · doi:10.1086/314032 · Cited by 538
McMinn, P., Stratov, I., Nagarajan, L., & Davis, S. (2001) · Clinical Infectious Diseases · doi:10.1086/318454 · Cited by 401
Enteroviral infections of the central nervous system.
Rotbart, H. A. (1995) · Clinical Infectious Diseases · doi:10.1093/clinids/20.4.971 · Cited by 312
Wang, S., Liu, C., Tseng, H., Wang, J., Huang, C., Chen, Y., Yang, Y., Lin, S., & Yeh, T. (1999) · Clinical Infectious Diseases · doi:10.1086/520149 · Cited by 303
Metadata
- Authors
- Ishimaru, Y., Nakano, S., Yamaoka, K., & Takami, S.
- Venue
- Archives of Disease in Childhood
- Publisher
- BMJ
- Published
- 1980-08-01
- Volume
- 55
- Issue
- 8
- Pages
- 583-588
- ISSN
- 0003-9888 (ISSN-L)
- 1468-2044
- OpenAlex
- W1992147205
- Cited by
- 232
- References
- 0
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Outbreaks of hand, foot, and mouth disease by enterovirus 71. High incidence of complication disorders of central nervous system. https://app.cochat.ai/papers/10.1136/adc.55.8.583
- The paper
- Ishimaru, Y., Nakano, S., Yamaoka, K., & Takami, S. (1980). Outbreaks of hand, foot, and mouth disease by enterovirus 71. High incidence of complication disorders of central nervous system. Archives of Disease in Childhood. https://doi.org/10.1136/adc.55.8.583
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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