The DOI matches its Crossref record.
Apparent prevention of neural tube defects by periconceptional vitamin supplementation.
Open accessAbstract
An earlier preliminary paper is expanded. Women who had given birth to one or more infants with a neural tube defect were recruited into a trial of per conceptional vitamin supplementation. Two hundred mothers attending five centres were fully supplemented (FS), 50 were partially supplemented (PS), and 300 were unsupplemented (US). Neural tube defect recurrences in the study pregnancies were 1 (0.5%), in FS, none in PS, and 13 (4%) in US mothers. The difference in outcome between FS and US mothers is significant. The most likely explanation is that supplementation has prevented some neural tube defects, but further studies are needed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Neural tube defects and folate: case far from closed
Blom, H. J., Shaw, G. M., den Heijer, M., & Finnell, R. H. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1986 · Cited by 562
FURTHER EXPERIENCE OF VITAMIN SUPPLEMENTATION FOR PREVENTION OF NEURAL TUBE DEFECT RECURRENCES
Smithells, R. W., Seller, M. J., Harris, R., Fielding, D. W., Schorah, C. J., Nevin, N. C., Sheppard, S., Read, A. P., Walker, S., & Wild, J. (1983) · The Lancet · doi:10.1016/s0140-6736(83)92654-5 · Cited by 383
Self-citationMacLehose, Reeves, Harvey, Sheldon, Russell, & Black (2000) · Health Technology Assessment · doi:10.3310/hta4340 · Cited by 311
Preconception care: nutritional risks and interventions
Dean, S. V., Lassi, Z. S., Imam, A. M., & Bhutta, Z. A. (2014) · Reproductive Health · doi:10.1186/1742-4755-11-s3-s3 · Cited by 279
Brent, R. L., & Fawcett, L. B. (1998) · The Journal of Pediatrics · doi:10.1016/s0022-3476(98)70522-0 · Cited by 40
Metadata
- Authors
- Smithells, R. W., Sheppard, S., Schorah, C. J., Seller, M. J., Nevin, N. C., Harris, R., Read, A. P., & Fielding, D. W.
- Venue
- Archives of Disease in Childhood
- Publisher
- BMJ
- Published
- 1981-12-01
- Volume
- 56
- Issue
- 12
- Pages
- 911-918
- ISSN
- 0003-9888 (ISSN-L)
- 1468-2044
- OpenAlex
- W2142465069
- Cited by
- 385
- References
- 0
- FWCI
- 23.65
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Apparent prevention of neural tube defects by periconceptional vitamin supplementation. https://app.cochat.ai/papers/10.1136/adc.56.12.911
- The paper
- Smithells, R. W., Sheppard, S., Schorah, C. J., Seller, M. J., Nevin, N. C., Harris, R., Read, A. P., & Fielding, D. W. (1981). Apparent prevention of neural tube defects by periconceptional vitamin supplementation. Archives of Disease in Childhood. https://doi.org/10.1136/adc.56.12.911
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
