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Efficacy and safety of tocilizumab in patients with refractory Takayasu arteritis: results from a randomised, double-blind, placebo-controlled, phase 3 trial in Japan (the TAKT study)

Nakaoka, Yoshikazu, Isobe, Mitsuaki, Takei, Syuji, Tanaka, Yoshiya, Ishii, Tomonori, Yokota, Shumpei, Nomura, Akira, Yoshida, Seitaro, Nishimoto, Norihiro·2018·Annals of the Rheumatic Diseases
DOI 10.1136/annrheumdis-2017-211878PMC PMC5867398
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Figure 1 Kaplan-Meier curves showing time to relapse* in the intent-to-treat population (primary endpoint, A) and per-protocol set (sensitivity analysis, B) according to the protocol definition. *Two or more of five signs of relapse present: objective systemic symptoms, subjective systemic symptoms, elevated inflammation markers, vascular signs and symptoms, ischaemic symptoms. SC, subcutaneous; TCZ, tocilizumab.
Figure 1 Kaplan-Meier curves showing time to relapse* in the intent-to-treat population (primary endpoint, A) and per-protocol set (sensitivity analysis, B) according to the protocol definition. *Two or more of five signs of relapse present: objective systemic symptoms, subjective systemic symptoms, elevated inflammation markers, vascular signs and symptoms, ischaemic symptoms. SC, subcutaneous; TCZ, tocilizumab.CC BY-NC · PubMed Central
Figure 2 Forest plot showing the HR for each symptom in the protocol-based definition of relapse (intent-to-treat population). Data are based on Cox regression analysis and stratified by age (<18, 18–<65, ≥65 years). HRs and 95% CIs are shown in the plot. NE, not evaluable; SC, subcutaneous; TCZ, tocilizumab.
Figure 2 Forest plot showing the HR for each symptom in the protocol-based definition of relapse (intent-to-treat population). Data are based on Cox regression analysis and stratified by age (<18, 18–<65, ≥65 years). HRs and 95% CIs are shown in the plot. NE, not evaluable; SC, subcutaneous; TCZ, tocilizumab.CC BY-NC · PubMed Central

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Research works printed but not linked: 39

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Metadata

Authors
Nakaoka, Y., Isobe, M., Takei, S., Tanaka, Y., Ishii, T., Yokota, S., Nomura, A., Yoshida, S., & Nishimoto, N.
Venue
Annals of the Rheumatic Diseases
Publisher
Elsevier BV
Published
2018-03
Volume
77
Issue
3
Pages
348-354
ISSN
0003-4967
DOI
10.1136/annrheumdis-2017-211878
PMC
PMC5867398
Cited by
344
References
0
Language
en
Licence
Funders
  • Chugai Pharmaceutical Co., Ltd.
  • F. Hoffmann-La Roche Ltd.

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CoChat. (2026). Citation check: Efficacy and safety of tocilizumab in patients with refractory Takayasu arteritis: results from a randomised, double-blind, placebo-controlled, phase 3 trial in Japan (the TAKT study). https://app.cochat.ai/papers/10.1136/annrheumdis-2017-211878
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Nakaoka, Y., Isobe, M., Takei, S., Tanaka, Y., Ishii, T., Yokota, S., Nomura, A., Yoshida, S., & Nishimoto, N. (2018). Efficacy and safety of tocilizumab in patients with refractory Takayasu arteritis: results from a randomised, double-blind, placebo-controlled, phase 3 trial in Japan (the TAKT study). Annals of the Rheumatic Diseases. https://doi.org/10.1136/annrheumdis-2017-211878