The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Towards understanding global patterns of antimicrobial use and resistance in neonatal sepsis: insights from the NeoAMR network
Open accessAbstract
Objective: To gain an understanding of the variation in available resources and clinical practices between neonatal units (NNUs) in the low-income and middle-income country (LMIC) setting to inform the design of an observational study on the burden of unit-level antimicrobial resistance (AMR). Design: A web-based survey using a REDCap database was circulated to NNUs participating in the Neonatal AMR research network. The survey included questions about NNU funding structure, size, admission rates, access to supportive therapies, empirical antimicrobial guidelines and period prevalence of neonatal blood culture isolates and their resistance patterns. Setting: 39 NNUs from 12 countries. Patients: Any neonate admitted to one of the participating NNUs. Interventions: This was an observational cohort study. Results: The number of live births per unit ranged from 513 to 27 700 over the 12-month study period, with the number of neonatal cots ranging from 12 to 110. The proportion of preterm admissions <32 weeks ranged from 0% to 19%, and the majority of units (26/39, 66%) use Essential Medicines List ‘Access’ antimicrobials as their first-line treatment in neonatal sepsis. Cephalosporin resistance rates in Gram-negative isolates ranged from 26% to 84%, and carbapenem resistance rates ranged from 0% to 81%. Glycopeptide resistance rates among Gram-positive isolates ranged from 0% to 45%. Conclusion: AMR is already a significant issue in NNUs worldwide. The apparent burden of AMR in a given NNU in the LMIC setting can be influenced by a range of factors which will vary substantially between NNUs. These variations must be considered when designing interventions to improve neonatal mortality globally.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In neonatal sepsis, 31% of mortalities (690,000) reported were plausibly attributed to antimicrobial-resistant infections.
“In neonatal sepsis, 31% of mortalities (690,000) reported were plausibly attributed to antimicrobial-resistant infections.”
From Antimicrobial Resistance Rates and Surveillance in Sub-Saharan Africa: Where Are We Now? (2022) · cites this paper as [11]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Liu, L., Oza, S., Hogan, D., Chu, Y., Perin, J., Zhu, J., Lawn, J. E., Cousens, S., Mathers, C., & Black, R. E. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31593-8 · Cited by 3,453
Flagged first, then by citations
Research works printed but not linked: 16
- 10.1016/S0140-6736(15)00474-2 · DOI · Paper page
- Hay, 2018, Measuring and mapping the global burden of antimicrobial resistance, BMC Med, 16, 10.1186/s12916-018-1073-z · DOI
- 10.1016/S2214-109X(16)30148-6 · DOI
- 10.1136/archdischild-2017-313595 · DOI
- Fuchs, 2018, Optimising β -lactam dosing in neonates: a review of pharmacokinetics, drug exposure and pathogens, Curr Pharm Des, 23, 5805, 10.2174/1381612823666170925162143 · DOI
- 10.1086/423961 · DOI
- 10.1159/000353458 · DOI
- Watson, 2014, The effects of designation and volume of neonatal care on mortality and morbidity outcomes of very preterm infants in England: retrospective population-based cohort study, BMJ Open, 4, 10.1136/bmjopen-2014-004856 · DOI
- 10.1016/j.ijid.2016.08.002 · DOI
- Laupland, 2018, Culturing rate and the surveillance of bloodstream infections: a population-based assessment, Clin Microbiol Infect, 24, 10.1016/j.cmi.2017.12.021 · DOI
- 10.1097/01.PCC.0000161583.34305.A0 · DOI
- Le Doare, 2017, SIgA, TGF-β1, IL-10, and TNFα in colostrum are associated with infant group B Streptococcus Colonization, Front Immunol, 8, 10.3389/fimmu.2017.01269 · DOI
- Russell, 2017, Risk of early-onset neonatal group B streptococcal disease with maternal colonization worldwide: systematic review and meta-analyses, Clin Infect Dis, 65, S152, 10.1093/cid/cix655 · DOI
- Azarian, 2016, Genomic epidemiology of methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit, PLoS One, 11, 10.1371/journal.pone.0164397 · DOI
- Battin, 2012, Improvement in mortality of very low birthweight infants and the changing pattern of neonatal mortality: the 50-year experience of one perinatal centre, J Paediatr Child Health, 48, 596, 10.1111/j.1440-1754.2012.02425.x · DOI
- 10.1093/cid/cix663 · DOI
Cited by
Sorted by citations
Antimicrobial Resistance Rates and Surveillance in Sub-Saharan Africa: Where Are We Now?
Kariuki, S., Kering, K., Wairimu, C., Onsare, R., & Mbae, C. (2022) · Infection and Drug Resistance · doi:10.2147/idr.s342753 · Cited by 245
Metadata
- Authors
- Li, G., Bielicki, J. A., Ahmed, A. S. M. N. U., Islam, M. S., Berezin, E. N., Gallacci, C. B., Guinsburg, R., da Silva Figueiredo, C. E., Santarone Vieira, R., Silva, A. R., Teixeira, C., Turner, P., Nhan, L., Orrego, J., Pérez, P. M., Qi, L., Papaevangelou, V., Triantafyllidou, P., Iosifidis, E., Roilides, E., Sarafidis, K., Jinka, D. R., Nayakanti, R. R., Kumar, P., Gautam, V., Prakash, V., Seeralar, A., Murki, S., Kandraju, H., Singh, S., Kumar, A., Lewis, L., Pukayastha, J., Nangia, S., K N, Y., Chaurasia, S., Chellani, H., Obaro, S., Dramowski, A., Bekker, A., Whitelaw, A., Thomas, R., Velaphi, S. C., Ballot, D. E., Nana, T., Reubenson, G., Fredericks, J., Anugulruengkitt, S., Sirisub, A., Wong, P., Lochindarat, S., Boonkasidecha, S., Preedisripipat, K., Cressey, T. R., Paopongsawan, P., Lumbiganon, P., Pongpanut, D., Sukrakanchana, P.-O., Musoke, P., Olson, L., Larsson, M., Heath, P. T., & Sharland, M.
- Affiliations
- University of London (GB)
- Bangladesh Shishu (Children) Hospital & Institute (BD)
- Faculdade de Ciências Médicas da Santa Casa de São Paulo (BR)
- Universidade Federal de São Paulo (BR)
- Cambodia-Oxford Medical Research Unit (KH)
- Angkor Hospital for Children (KH)
- Fundación Valle del Lili (CO)
- Shenzhen Children's Hospital (CN)
- National and Kapodistrian University of Athens (GR)
- University General Hospital Attikon (GR)
- Aristotle University of Thessaloniki (GR)
- Post Graduate Institute of Medical Education and Research (IN)
- Fernandez Hospital (IN)
- Amrita Institute of Medical Sciences and Research Centre (IN)
- Kasturba Medical College, Manipal (IN)
- Lady Hardinge Medical College (IN)
- All India Institute of Medical Sciences (IN)
- Vardhman Mahavir Medical College & Safdarjung Hospital (IN)
- International Foundation Against Infectious Disease in Nigeria (NG)
- Stellenbosch University (ZA)
- National Health Laboratory Service (ZA)
- University of the Witwatersrand (ZA)
- Chulalongkorn University (TH)
- Siriraj Hospital (TH)
- Queen Sirikit National Institute of Child Health (TH)
- ChiangRai Prachanukroh Hospital (TH)
- Khon Kaen University (TH)
- Phayao Hospital (TH)
- Mulago Hospital (UG)
- Karolinska Institutet (SE)
- ORCID
- Li, Grace
- Bielicki, Julia Anna
- Islam, Mohammad Shahidul
- Berezin, Eitan Naaman
- Guinsburg, Ruth
- Turner, Paul
- Qi, Lifeng
- Papaevangelou, Vassiliki
- Roilides, Emmanuel
- Sarafidis, Kosmas
- Jinka, Dasaratha Ramaiah
- Kumar, Praveen
- Gautam, Vikas
- Murki, Srinivas
- Kandraju, Hemasree
- Singh, Sanjeev
- Kumar, Anil
- Lewis, Leslie
- Nangia, Sushma
- Chaurasia, Suman
- Chellani, Harish
- Obaro, Stephen
- Dramowski, Angela
- Bekker, Adrie
- Whitelaw, Andrew
- Thomas, Reenu
- Velaphi, Sithembiso Christopher
- Ballot, Daynia Elizabeth
- Nana, Trusha
- Reubenson, Gary
- Anugulruengkitt, Suvaporn
- Lochindarat, Sorasak
- Boonkasidecha, Suppawat
- Preedisripipat, Kanchana
- Cressey, Tim R
- Paopongsawan, Pongsatorn
- Lumbiganon, Pagakrong
- Sukrakanchana, Pra-ornsuda
- Musoke, Philippa
- Olson, Linus
- Larsson, Mattias
- Heath, Paul T
- Venue
- Archives of Disease in Childhood
- Publisher
- BMJ
- Published
- 2019-08-24
- Volume
- 105
- Issue
- 1
- Pages
- 26-31
- ISSN
- 0003-9888 (ISSN-L)
- 1468-2044
- PMC
- PMC6951234
- OpenAlex
- W2969858855
- Cited by
- 106
- References
- 1
- Citations by year
- 2026: 8 · 2025: 19 · 2024: 23 · 2023: 17 · 2022: 13 · 2021: 17 · 2020: 8 · 2019: 1
- FWCI
- 8.98
- Type
- journal article
- Language
- en
- Update notices
- correction (2020-03-27)
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Archives of Disease in Childhood (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- St George's Online Research Archive (St George's University of London) (acceptedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- Arca - Repositório Institucional da Fiocruz (submittedVersion, other-oa)
- HighWire Press Open Archive (submittedVersion)
- SUNScholar (Stellenbosch University) (submittedVersion)
- Funders
- Jinan University
- Beijing Children's Hospital, Capital Medical University
- Faculty of Medicine Siriraj Hospital, Mahidol University
- Beijing Obstetrics and Gynecology Hospital, Capital Medical University
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
- Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Keywords
- neonatal sepsis, antimicrobial resistance, antimicrobial use, neonatal unit, low- and middle-income countries, blood culture isolates, cephalosporin resistance, carbapenem resistance, glycopeptide resistance, neonatal mortality
- MeSH terms
- Neonatal Sepsis, Anti-Infective Agents, Developing Countries, Humans, Infant, Newborn, Surveys and Questionnaires, Global Health, Drug Resistance, Bacterial
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
