The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Comparison of a high sensitivity and standard C reactive protein measurement in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis
Abstract
Objective This study was aimed at comparing high sensitivity C reactive protein (hsCRP) measurement with routine C reactive protein (CRP) evaluation as disease activity parameters in patients with ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nrSpA). Methods A total of 269 patients (153 with AS and 116 with nrSpA) were included. Level of hsCRP was measured using particle-enhanced immunoturbidimetric method with the lowest detected level of 0.1 mg/litre. The hsCRP values were compared to results of routine turbidimetric CRP test with the lowest detected level of 6 mg/litre. Results In the whole group of patients with AS, hsCRP showed a better than routine CRP correlation with clinical parameters. In the whole group of patients with nrSpA, hsCRP correlated with the level of enthesitis-related tenderness only. In the AS subgroup with a negative routine CRP ( Conclusions hsCRP correlates better than routine CRP with clinical disease activity parameters in patients with axial SpA, especially in AS. Therefore, hsCRP could be superior to standard CRP in assessing disease activity in axial SpA.
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Vodolazkaia, A., Bossuyt, X., Fassbender, A., Kyama, C. M., Meuleman, C., Peeraer, K., Tomassetti, C., & D'Hooghe, T. M. (2011) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-9-113 · Cited by 28
“Routine CRP assays often do not quantify CRP concentrations below the upper normal limit that may be relevant to detect subclinical inflammation which may occur early during disease development [29].”
BackgroundResult
Metadata
- Authors
- Poddubnyy, D., Rudwaleit, M., Listing, J., Braun, J., & Sieper, J.
- Affiliations
- Stiftung Charité (DE)
- German Rheumatism Research Centre (DE)
- Rheumazentrum Ruhrgebiet (DE)
- Venue
- Annals of the Rheumatic Diseases
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 69
- Issue
- 7
- Pages
- 1338-1341
- ISSN
- 0003-4967 (ISSN-L)
- OpenAlex
- W2162036715
- Cited by
- 85
- References
- 15
- Citations by year
- 2026: 3 · 2024: 3 · 2023: 10 · 2022: 3 · 2021: 3 · 2020: 8 · 2019: 6 · 2018: 4 · 2017: 2 · 2016: 7 · 2015: 3 · 2014: 9 · 2013: 7 · 2012: 12
- FWCI
- 5.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Annals of the Rheumatic Diseases (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Spondyloarthritis Studies and Treatments
- Health Sciences › Medicine › Rheumatology › Osteomyelitis and Bone Disorders Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoidosis and Beryllium Toxicity Research
- Keywords
- high-sensitivity C-reactive protein, C-reactive protein, ankylosing spondylitis, non-radiographic axial spondyloarthritis, axial spondyloarthritis, disease activity, inflammatory markers, functional disability
- MeSH terms
- Adult, C-Reactive Protein, Female, Humans, Male, Nephelometry and Turbidimetry, Sensitivity and Specificity, Severity of Illness Index, Spondylitis, Ankylosing, Biomarkers, Spondylarthritis
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