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Cited by 297

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Explaining the cardiovascular risk associated with rheumatoid arthritis: traditional risk factors versus markers of rheumatoid arthritis severity

Open access
Solomon, Daniel H, Kremer, Joel, Curtis, Jeffrey R, Hochberg, Marc C, Reed, George, Tsao, Peter, Farkouh, Michael E, Setoguchi, Soko, Greenberg, Jeffrey D·2010·Annals of the Rheumatic Diseases

Abstract

Background Cardiovascular (CV) disease has a major impact on patients with rheumatoid arthritis (RA), however, the relative contributions of traditional CV risk factors and markers of RA severity are unclear. The authors examined the relative importance of traditional CV risk factors and RA markers in predicting CV events. Methods A prospective longitudinal cohort study was conducted in the setting of the CORRONA registry in the USA. Baseline data from subjects with RA enrolled in the CORRONA registry were examined to determine predictors of CV outcomes, including myocardial infarction, stroke or transient ischemic attack. Possible predictors were of two types: traditional CV risk factors and markers of RA severity. The discriminatory value of these variables was assessed by calculating the area under the receiver operating characteristic curve (c-statistic) in logistic regression. The authors then assessed the incidence rate for CV events among subjects with an increasing number of traditional CV risk factors and/or RA severity markers. Results The cohort consisted of 10 156 patients with RA followed for a median of 22 months. The authors observed 76 primary CV events during follow-up for a composite event rate of 3.98 (95% CI 3.08 to 4.88) per 1000 patient-years. The c-statistic improved from 0.57 for models with only CV risk factors to 0.67 for models with CV risk factors plus age and gender. The c-statistic improved further to 0.71 when markers of RA severity were also added. The incidence rate for CV events was 0 (95% CI 0 to 5.98) for persons without any CV risk factors or markers of RA severity, while in the group with two or more CV risk factors and three or more markers of RA severity the incidence was 7.47 (95% CI 4.21 to 10.73) per 1000 person-years. Conclusions Traditional CV risk factors and markers of RA severity both contribute to models predicting CV events. Increasing numbers of both types of factors are associated with greater risk.

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Metadata

Authors
Solomon, D. H., Kremer, J., Curtis, J. R., Hochberg, M. C., Reed, G., Tsao, P., Farkouh, M. E., Setoguchi, S., & Greenberg, J. D.
Venue
Annals of the Rheumatic Diseases
Publisher
Elsevier BV
Published
2010-11
Volume
69
Issue
11
Pages
1920-1925
ISSN
0003-4967 (ISSN-L)
OpenAlex
W1990795149
Cited by
297
References
42
FWCI
14.05
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Explaining the cardiovascular risk associated with rheumatoid arthritis: traditional risk factors versus markers of rheumatoid arthritis severity. https://app.cochat.ai/papers/10.1136/ard.2009.122226
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Solomon, D. H., Kremer, J., Curtis, J. R., Hochberg, M. C., Reed, G., Tsao, P., Farkouh, M. E., Setoguchi, S., & Greenberg, J. D. (2010). Explaining the cardiovascular risk associated with rheumatoid arthritis: traditional risk factors versus markers of rheumatoid arthritis severity. Annals of the Rheumatic Diseases. https://doi.org/10.1136/ard.2009.122226

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.