NT-proBNP predicts mortality in patients with rheumatoid arthritis: results from 10-year follow-up of the EURIDISS study
Abstract
Objectives Patients with rheumatoid arthritis (RA) have a higher mortality than the general population, and this increased mortality is related to demographic and disease variables. N-terminal pro-brain natriuretic peptide (NT-proBNP) is a predictor of mortality both in general and patient populations, but has not been shown to predict mortality in patients with RA. This study examines whether NT-proBNP can further improve the prediction of mortality in RA.Methods 182 patients with RA of 5-9 years disease duration were comprehensively examined in 1997. Serum samples were frozen and later batch analysed for NT-proBNP levels and other biomarkers. Adjusted univariate and logistic regression analyses were performed with death within the 10-year follow-up period as the dependent variable. Significant predictors were also examined as dichotomised variables.Results Mortality was predicted in univariate analyses by the following variables: age, sex, homozygosity for HLA-DRB1 shared epitope alleles, Health Assessment Questionnaire, 28-joint Disease Activity Score (DAS28) and NT-proBNP. A multivariate model with age, sex, DAS28 and NT-proBNP as independent variables showed the greatest discrimination.Conclusion NT-proBNP provided incremental information in the prediction of mortality in this cohort of patients with RA.
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In chronic inflammatory diseases, serum levels of atrial natriuretic factor and NT-brain natriuretic factor are markedly increased, indicating volume overload.
“there are obvious signs of volume overload in chronic inflammatory diseases because serum levels of atrial natriuretic factor and NT-brain natriuretic factor are markedly increased in different diseases [49–52].”
From Evolutionary medicine and chronic inflammatory state—known and new concepts in pathophysiology (2012) · cites this paper as [52]
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Evolutionary medicine and chronic inflammatory state—known and new concepts in pathophysiology
Straub, R. H. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-012-0861-8 · Cited by 105 · see citing works
- Authors
- Provan, S., Angel, K., Semb, A. G., Atar, D., & Kvien, T. K.
- Affiliations
- Diakonhjemmet Hospital (NO)
- Oslo University Hospital (NO)
- Corresponding author
- Provan, Sella
- Venue
- Annals of the Rheumatic Diseases
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 69
- Issue
- 11
- Pages
- 1946-1950
- ISSN
- 0003-4967 (ISSN-L)
- OpenAlex
- W2133846358
- Cited by
- 50
- References
- 31
- Citations by year
- 2025: 5 · 2024: 6 · 2023: 4 · 2022: 3 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 2
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Annals of the Rheumatic Diseases (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
- Keywords
- rheumatoid arthritis, NT-proBNP, mortality prediction, cardiovascular risk, biomarkers, HLA-DRB1 shared epitope, DAS28, prognostic factors
- MeSH terms
- Adult, Age Factors, Aged, Arthritis, Rheumatoid, Epidemiologic Methods, Female, Humans, Male, Middle Aged, Norway, Peptide Fragments, Prognosis, Sex Factors, Biomarkers, Natriuretic Peptide, Brain
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