The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study
Open accessAbstract
Objective Low back pain (LBP) is a common musculoskeletal disorder, but it is still unclear which individuals develop it. The authors examined the contribution of genetic factors, lumbar disc degeneration (LDD) and other risk factors in a female sample of the general population. Material and Methods A cross-sectional study was conducted among 2256 women (371 and 698 monozygotic and dizygotic twin pairs and 29 sibling pairs and 60 singletons) with a mean age of 50 years (18–84). A self-reported validated questionnaire was used to collect back pain data. Risk factors including body weight, smoking, occupation, physical exercise and MRI assessed LDD were measured. Data analysis included logistic regression and variance decomposition. Results The major factors associated with LBP included genetic background, with OR approximately 6 if the monozygotic co-twin had LBP, or 2.2 if she was a dizygotic co-twin. In addition, LDD and overweight were highly significantly (p<0.001) associated with non-specific LBP. The single most important risk factor was the amount of LDD. After adjustment for other risk factors, the individuals who exhibited advanced LDD (90% vs 10%) had 3.2 higher odds of manifesting LBP. The data also showed a significant (p<0.001) genetic correlation between the LBP and LDD measurements, suggesting that approximately 11–13% of the genetic effects are shared by LDD and LBP. Conclusions The main risk factors for reported episodes of severe and disabling LBP in UK women include the degree of LDD as assessed by MRI, being overweight and genetic heritability.
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Cites
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Shiri, R., Karppinen, J., Leino-Arjas, P., Solovieva, S., & Viikari-Juntura, E. (2010) · American Journal of Epidemiology · doi:10.1093/aje/kwp356 · Cited by 909
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“24 The following radiographic coding on a scale of 0–3 was made for each of the fi ve intervertebral discs in the lumbar spine: (1) disc signal intensity within the nucleus pulposus; (2) disc height; (3) disc extension and (4) anterior osteophytes.”
MethodThe Association between Smoking and Low Back Pain: A Meta-analysis
Shiri, R., Karppinen, J., Leino-Arjas, P., Solovieva, S., & Viikari-Juntura, E. (2010) · The American Journal of Medicine · doi:10.1016/j.amjmed.2009.05.028 · Cited by 590
Cited by
Role of cytokines in intervertebral disc degeneration: pain and disc content
Risbud, M. V., & Shapiro, I. M. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.160 · Cited by 1,767
A new immunometabolic perspective of intervertebral disc degeneration
Francisco, V., Pino, J., González-Gay, M. Á., Lago, F., Karppinen, J., Tervonen, O., Mobasheri, A., & Gualillo, O. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00713-z · Cited by 462
Disc in flames: Roles of TNF-α and IL-1β in intervertebral disc degeneration
1025 Walnut Street, S. 5. C. B., Johnson, Z., Schoepflin, Z., Choi, H., Shapiro, I., & Risbud, M. (2015) · European Cells and Materials · doi:10.22203/ecm.v030a08 · Cited by 386
Gilbert, H. T. J., Hodson, N., Baird, P., Richardson, S. M., & Hoyland, J. A. (2016) · Scientific Reports · doi:10.1038/srep37360 · Cited by 140
Current Understanding of the Genetics of Intervertebral Disc Degeneration
Dickinson, P. J., & Bannasch, D. L. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.00431 · Cited by 58
Metadata
- Authors
- Livshits, G., Popham, M., Malkin, I., Sambrook, P. N., MacGregor, A. J., Spector, T., & Williams, F. M. K.
- Venue
- Annals of the Rheumatic Diseases
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 70
- Issue
- 10
- Pages
- 1740-1745
- ISSN
- 0003-4967 (ISSN-L)
- OpenAlex
- W2105081732
- Cited by
- 465
- References
- 32
- FWCI
- 12.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Livshits, G., Popham, M., Malkin, I., Sambrook, P. N., MacGregor, A. J., Spector, T., & Williams, F. M. K. (2011). Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study. Annals of the Rheumatic Diseases. https://doi.org/10.1136/ard.2010.137836
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