Mitral valve prolapse and joint hypermobility: evidence for a systemic connective tissue abnormality?
Open accessAbstract
Clinical evidence for an abnormally of extracardiac connective tissue was sought in 21 patients with idiopathic mitral valve prolapse and was compared to that in 21 matched controls. The incidence of rheumatic and orthopaedic complaints and the prevalence of hypermobile joints, Marfanoid habitus, and skeletal deformity were compared in the 2 groups. Skin thickness and elasticity were measured, and the mean values in the 2 groups were compared. hypermobile joints were significantly commoner in patients with mitral valve prolapse. Easy bruising was reported significantly more commonly by patients with mitral prolapse; the incidence of other rheumatic complaints was similar in the 2 groups. There was no significant difference in skin thickness, skin elasticity, and the prevalence of either skeletal deformity or Marfanoid habitus between patients with mitral valve prolapse and controls. The results support previous evidence of an association between mitral valve prolapse and benign hypermobility of the joints, but emphasise that many patients with mitral valve prolapse have no clinically apparent connective tissue abnormality outside the heart. It remains uncertain whether the valve lesion in these patients represents a tissue-specific abnormality of mitral valve collagen or the only clinical expression of a minor systemic connective tissue abnormality.
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The prevalence of mental disorders in children and adolescents that moderately interferes with their performance is around 20%, and anxiety disorder is the most prevalent (13%).
“The prevalence of mental disorders in children and adolescents that moderately interferes with their performance has been reported to be around 20%, among which anxiety disorder is the most prevalent (13%) [14].”
From Prevalence of generalized joint hypermobility in children with anxiety disorders (2020) · cites this paper as [14]
The Patients and methods section (p. 352) describes adults recruited from a cardiology clinic for a study of mitral valve prolapse. The Discussion addresses joint mobility and rheumatic complaints. Searches for mental disorders, children and adolescents, anxiety, and the stated prevalence figures found no passage addressing the claim. (LLM, conf=0.79)
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Russek, L. N. (1999) · Physical Therapy · doi:10.1093/ptj/79.6.591 · Cited by 115 · see citing works
Prevalence of generalized joint hypermobility in children with anxiety disorders
Javadi Parvaneh, V., Modaress, S., Zahed, G., Rahmani, K., & Shiari, R. (2020) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-020-03377-0 · Cited by 9 · see citing works
- Authors
- Pitcher, D., & Grahame, R.
- Affiliations
- Guy's Hospital (GB)
- Venue
- Annals of the Rheumatic Diseases
- Publisher
- Elsevier BV
- Published
- 1982-08
- Volume
- 41
- Issue
- 4
- Pages
- 352-354
- ISSN
- 0003-4967 (ISSN-L)
- PMC
- PMC1000950
- OpenAlex
- W2162011755
- Cited by
- 48
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2021: 1 · 2020: 2 · 2017: 1 · 2015: 1 · 2013: 1
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of the Rheumatic Diseases (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
- Health Sciences › Health Professions › Pharmacy › Oral and gingival health research
- Keywords
- mitral valve prolapse, joint hypermobility, connective tissue abnormalities, skin elasticity, skin thickness, easy bruising, Marfanoid habitus, skeletal deformities, rheumatic complaints, collagen
- MeSH terms
- Adult, Connective Tissue Diseases, Female, Humans, Joint Diseases, Male, Middle Aged, Mitral Valve Prolapse, Movement
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