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Cited by 115Connective tissue disorders researchMusculoskeletal pain and rehabilitationOral and gingival health research

Hypermobility syndrome

Russek, Leslie N·1999·Physical Therapy
DOI 10.1093/ptj/79.6.591
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Abstract

Hypermobility syndrome was recognized as a distinct pathology by Kirk et al1 in 1967. Since then, the syndrome has been identified by a variety of names: “hypermobility syndrome (HMS),”2–9 “joint hypermobility syndrome,”10–13 “hypermobile joint syndrome,”14 and “benign hypermobile joint syndrome.”15,16 Other reports do not recognize this disorder as a syndrome, but refer to the manifestations of joint hyperlaxity, joint hypermobility, or articular hypermobility. In the International Nosology of Heritable Disorders of Connective Tissue, Beighton et al17 identified this syndrome as “familial articular hypermobility syndrome.” Beighton et al excluded genetic diseases that include joint hypermobility as an associated finding, such as Ehlers-Danlos syndrome, osteogenesis imperfecta, and Marfan syndrome. Despite the proliferation of names, HMS has been given relatively little attention in the literature. Most reports are in the rheumatology literature, with virtually none in the orthopedic or physical therapy literature. This lack of reports may be due to several reasons. First, individuals with HMS are often seen by orthopedic physicians and physical therapists as a result of an acute or chronic disorder, which may be treated without the health care provider acknowledging the underlying HMS. Second, the diagnostic criteria for HMS are not well-defined and have not been consistent among research reports.8,18–20 In particular, patients with HMS lack laboratory or radiological findings that could identify HMS, unlike many other rheumatologic or orthopedic conditions. The diagnosis, therefore, is frequently made through exclusion of other disorders. Third, individuals with HMS often do not have the decreased mobility seen with many chronic conditions,4 nor do they always have the inflammation seen with many acute conditions. Finally, because HMS lacks a definitive pharmacological or surgical treatment, physicians may have perceived little benefit in its diagnosis.

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Authors
Russek, L. N.
Affiliations
Clarkson University (US)
Corresponding author
Russek, Leslie N
ORCID
Russek, Leslie N
Venue
Physical Therapy
Publisher
Oxford University Press (OUP)
Published
1999-06-01
Volume
79
Issue
6
Pages
591-599
ISSN
  • 0031-9023 (ISSN-L)
  • 1538-6724
DOI
10.1093/ptj/79.6.591
OpenAlex
W4239425187
Cited by
115
References
78
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 5 · 2020: 1 · 2019: 7 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 9 · 2014: 9 · 2013: 4 · 2012: 4
FWCI
0.52
Type
journal article
Language
en
Open access
closed
Locations
Physical Therapy (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
  • Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
  • Health Sciences › Health Professions › Pharmacy › Oral and gingival health research
Keywords
hypermobility syndrome, joint hypermobility, Ehlers-Danlos syndrome

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