Necrotising granulomatous lymphadenitis
Open accessAbstract
Extrapulmonary tuberculosis (EPTB) is defined as Mycobacterium TB through Ziehl–Neelsen acid-fast stain and culture in Loewenstein–Jensen in a tissue from a site other than lung parenchyma, in association with clinical or imaging findings compatible with infection locally. The authors report a case of a patient who presented with asthenia, anorexia and weight loss. He complained of fever, chills and night sweats of 1-week duration. The thoracic scan reveals lymph node enlargement in the left axilla and pleural effusion and the histological study revealed a necrotising granulomatous lymphadenitis. It was decided to initiate antituberculous drugs with a good response. EPTB is a difficult diagnostic because lymph nodes contain few tubercle bacilli, leading to a low sensitivity of smear microscopy detection. The introduction of antituberculous agents is the cornerstone of management of such infections and, occasionally, it is the only way to make a diagnosis.
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Flagged first, then by citations
- Authors
- Alves, F., Baptista, A., Brito, H., & Mendonça, I.
- Affiliations
- Hospital de Faro EPE (PT)
- Corresponding author
- Alves, François
- Venue
- BMJ Case Reports
- Publisher
- BMJ
- Published
- 2011
- Volume
- 2011
- Pages
- bcr1120103548
- ISSN
- 1757-790X (ISSN-L)
- PMC
- PMC3062882
- OpenAlex
- W2101838870
- Cited by
- 5
- References
- 28
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 2 · 2016: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ Case Reports (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Diagnosis and treatment of tuberculosis
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Surgery › Lymphadenopathy Diagnosis and Analysis
- Keywords
- extrapulmonary tuberculosis, lymphadenopathy, pleural effusion, tuberculosis treatment, Mycobacterium tuberculosis, histopathology, tuberculosis diagnosis
- MeSH terms
- Aged, 80 and over, Granuloma, Humans, Male, Necrosis, Tuberculosis, Lymph Node
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