Interleukin-8 promoter polymorphism -251A/T is a risk factor for age-related macular degeneration

Goverdhan, S V; Ennis, S; Hannan, S R; Madhusudhana, K C; Cree, A J; Luff, A J; Lotery, A J

doi:10.1136/bjo.2007.123190

Cited by 79Retinal Diseases and TreatmentsOcular Diseases and Behçet’s SyndromeRetinal Development and Disorders

Interleukin-8 promoter polymorphism -251A/T is a risk factor for age-related macular degeneration

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Goverdhan, S V, Ennis, S, Hannan, S R, Madhusudhana, K C, Cree, A J, Luff, A J, Lotery, A J·2008·British Journal of Ophthalmology

DOI 10.1136/bjo.2007.123190PMC PMC5993190

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Abstract

BACKGROUND/AIMS: To determine whether four expression-related cytokine polymorphisms are associated with age-related macular degeneration (AMD). METHODS: DNA from 478 cases with AMD and 555 normal controls was genotyped for the pro-inflammatory IL1beta -511C/T, IL6 -174C/G, IL8 -251A/T and anti-inflammatory IL10 -1082G/A cytokine polymorphisms using the 5' nuclease TaqMan(R) assay for allelic discrimination. Associations with AMD were analysed using allelic frequencies. RESULTS: The -251A allele of the IL8 promoter gene polymorphism was more prevalent in AMD patients than controls (p = 0.037, OR = 1.21, 95% CI = 1.01 to 1.44). Adjusting for age, sex, body mass index (BMI), current smoking and past smoking status did not alter the AMD association significantly (corrected p value = 0.043, OR = 1.23, 95% CI = 1.0 to 1.50). CONCLUSION: The pro-inflammatory homozygous IL8 -251AA genotype is an important risk factor for AMD. This may have implications for future therapy with biological agents that could target this cytokine.

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The IL8 A251T genetic polymorphism is associated with AMD, with the homozygous AA genotype as the at-risk factor.
“The interleukin-8 (IL8) A251T genetic polymorphism located in chromosome 4q13–21 is reported to be associated with AMD, with the homozygous AA genotype (A allele) as the “at risk” factor (Goverdhan et al., 2008).”
From Molecular pathology of age-related macular degeneration (2009) · cites this paper as Goverdhan et al., 2008
SNPs in IL1β C511T, IL6 C174G, and IL10 G1082A showed no significant association with AMD.
“SNPs in other pro-inflammatory chemokines including interleukin-1β (IL1β) C511T, interleukin-6 (IL6) C174G and the anti-inflammatory cytokine IL10 G1082A were analyzed and showed no significant association with AMD (Goverdhan et al., 2008).”
From Molecular pathology of age-related macular degeneration (2009) · cites this paper as Goverdhan et al., 2008
Multiple associations between AMD and HLA and cytokine genes have been reported.
“Multiple associations between AMD and HLA and cytokine genes have also been reported (57, 58).”
From Unraveling a Multifactorial Late-Onset Disease: From Genetic Susceptibility to Disease Mechanisms for Age-Related Macular Degeneration (2009) · cites this paper as [57]
Multiple associations between AMD and HLA and cytokine genes have also been reported.
“Multiple associations between AMD and HLA and cytokine genes have also been reported (57, 58).”
From Unraveling a Multifactorial Late-Onset Disease: From Genetic Susceptibility to Disease Mechanisms for Age-Related Macular Degeneration (2009) · cites this paper as [57]

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Molecular pathology of age-related macular degeneration
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“The interleukin-8 (IL8) A251T genetic polymorphism located in chromosome 4q13–21 is reported to be associated with AMD, with the homozygous AA genotype (A allele) as the “at risk” factor (Goverdhan et al., 2008).”
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Authors: Goverdhan, S. V., Ennis, S., Hannan, S. R., Madhusudhana, K. C., Cree, A. J., Luff, A. J., & Lotery, A. J.
Affiliations: Southampton General Hospital (GB)
Corresponding author: Lotery, A J
ORCID: Ennis, S
Cree, A J
Lotery, A J
Venue: British Journal of Ophthalmology
Publisher: BMJ
Published: 2008-02-29
Volume: 92
Issue: 4
Pages: 537-540
ISSN: 0007-1161 (ISSN-L)
DOI: 10.1136/bjo.2007.123190
PMC: PMC5993190
OpenAlex: W2133229267
Cited by: 79
References: 30
Citations by year: 2026: 1 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 9 · 2020: 4 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 8 · 2014: 4 · 2013: 7 · 2012: 11
FWCI: 6.42
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: British Journal of Ophthalmology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
ePrints Soton (University of Southampton) (submittedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Wellcome Trust (076169)
National Institutes of Health
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
Keywords: age-related macular degeneration, interleukin-8, genetic risk factors, cytokine gene polymorphisms, inflammatory cytokines, smoking, biologic therapy
MeSH terms: Aged, Aged, 80 and over, Female, Gene Frequency, Genotype, Humans, Macular Degeneration, Male, Middle Aged, Risk Factors, Interleukin-8, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide

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Interleukin-8 promoter polymorphism -251A/T is a risk factor for age-related macular degeneration

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