Retinal microangiopathy and pigment epithelial lesions in subjects with normal, borderline, and decreased oral glucose tolerance
Open accessAbstract
Retinal fluorescein angiography was performed in 150 subjects: 64 with normal fasting blood glucose and normal oral glucose tolerance test (OGTT), 49 with borderline, and 37 with decreased OGTT. Microaneurysms were noted in only two subjects, both with decreased OGTT. Minute changes in the retinal pigment epithelium (RPE) were seen in 23% of the 64 normal persons, in 35% of those with borderline, and 49% of those with decreased OGTT (p less than 0.05). The impact of glucose intolerance was more pronounced in subjects under the age of 50 years, RPE changes being rare (7%) in those with normal OGTT but occurring in 32% of those with borderline or decreased OGTT (p less than 0.01). The corresponding figures among subjects aged 50 or more were 55% and 57%, respectively. We conclude that at least half of the subjects above 50 years show RPE alterations, and that minimal changes in glucose metabolism may precipitate the development of such changes at an earlier age.
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Prediabetes status may be associated with an increased risk of diabetic retinopathy, although findings vary depending on the method of detection.
“Prediabetes status may be associated with an increased risk of diabetic retinopathy although the findings vary depending on the method of detection.51,79–83”
From Prediabetes: a high-risk state for diabetes development (2012) · cites this paper as [79]
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Ageing and degeneration in the macular region: A clinico-pathological study
Sarks, S. H. (1976) · British Journal of Ophthalmology · doi:10.1136/bjo.60.5.324 · Cited by 891 · see citing works
Nonketotic diabetes mellitus: Insulin deficiency or insulin resistance?
Reaven, G. M., Bernstein, R., Davis, B. M., & Olefsky, J. M. (1976) · The American Journal of Medicine · doi:10.1016/0002-9343(76)90536-2 · Cited by 356 · see citing works
The Retinal Pigment Epithelium
Wolter, J. R. (1980) · Journal of Pediatric Ophthalmology & Strabismus · doi:10.3928/0191-3913-19800301-18 · Cited by 272 · see citing works
Role of the retinal pigment epithelium in macular disease.
Hogan, M. J. (1972) · PubMed · Cited by 248 · see citing works
The Natural History of Retinopathy in Insulin-Dependent Juvenile-Onset Diabetes
Palmberg, P. F., Smith, M. E., Waltman, S. R., Krupin, T., Singer, P. R., Burgess, D. B., Wendtlant, T., Achtenberg, J. F., Cryer, P., Santiago, J., et al. (1981) · Ophthalmology · doi:10.1016/s0161-6420(81)34975-6 · Cited by 198 · see citing works
Alteration of the Blood-Retinal Barrier in Experimental Diabetes Mellitus
Waltman, S. R., Krupin, T., Hanish, S. J., Oestrich, C., & Becker, B. (1978) · Archives of Ophthalmology · doi:10.1001/archopht.1978.03910050480018 · Cited by 97 · see citing works
Grimes, P. A., & Laties, A. M. (1980) · Experimental Eye Research · doi:10.1016/0014-4835(80)90062-7 · Cited by 75 · see citing works
Pathologic studies of the blood--retinal barrier in the spontaneously diabetic BB rat.
Blair, N. P., Tso, M. O. M., & Dodge, J. T. (1984) · PubMed · Cited by 68 · see citing works
Early Detection of Retinal Involvement In Diabetes By Vitreous Fluorophotometry
Cunha-Vaz, J. G., Goldberg, M. F., Vygantas, C. M., et al. (1979) · Ophthalmology · doi:10.1016/s0161-6420(79)35516-6 · Cited by 58 · see citing works
Fluorometric Studies on the Blood-Retinal Barrier in Experimental Animals
Krupin, T., Waltman, S. R., Szewczyk, P., et al. (1982) · Archives of Ophthalmology · doi:10.1001/archopht.1982.01030030633021 · Cited by 48 · see citing works
Outward Transport of Fluorescein From the Vitreous in Normal Human Subjects
Blair, N. P., Zeimer, R. C., Rusin, M. M., et al. (1983) · Archives of Ophthalmology · doi:10.1001/archopht.1983.01040020119021 · Cited by 48 · see citing works
Retinopathy at Diagnosis of Diabetes, with Special Reference to Patients under 40 Years of Age
Soler, N. G., Fitzgerald, M. G., Malins, J. M., et al. (1969) · BMJ · doi:10.1136/bmj.3.5670.567 · Cited by 42 · see citing works
Insulin release, insulin sensitivity, and glucose intolerance.
Efendić, S., Wajngot, A., Cerasi, E., & Luft, R. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.12.7425 · Cited by 38 · see citing works
Self-citationAnstadt, B., Blair, N. P., Rusin, M. M., et al. (1982) · Experimental Eye Research · doi:10.1016/s0014-4835(82)80077-8 · Cited by 34 · see citing works
Jerneld, B., & Algvere, P. V. (1984) · Acta Ophthalmologica · doi:10.1111/j.1755-3768.1984.tb03974.x · Cited by 24 · see citing works
Self-citationDiabetic retinopathy with normal glucose tolerance.
Harrower, A. D. B., & Clarke, B. F. (1976) · British Journal of Ophthalmology · doi:10.1136/bjo.60.6.459 · Cited by 14 · see citing works
Retinal Pigment Epithelial Window Defect
Keno, D. D., & Green, W. R. (1978) · Archives of Ophthalmology · doi:10.1001/archopht.1978.03910050456012 · Cited by 14 · see citing works
THE NORMAL RETINAL FLUORESCEIN ANGIOGRAM I
Nielsen, N. V. (1982) · Acta Ophthalmologica · doi:10.1111/j.1755-3768.1982.tb06726.x · Cited by 11 · see citing works
THE DIAGNOSIS OF RETINOPATHY BY FLUORESCEIN ANGIOGRAPHY IN LATENT DIABETES
Zetterström, B., & Gjötterberg, M. (1974) · Acta Ophthalmologica · doi:10.1111/j.1755-3768.1974.tb00350.x · Cited by 4 · see citing works
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Prediabetes: a high-risk state for diabetes development
Tabák, A. G., Herder, C., Rathmann, W., Brunner, E. J., & Kivimäki, M. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60283-9 · Cited by 2,958 · see citing works
Prediabetes diagnosis and treatment: A review
Bansal, N. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i2.296 · Cited by 579 · see citing works
- Authors
- Algvere, P., Efendic, S., Luft, R., & Wajngot, A.
- Affiliations
- Karolinska University Hospital (SE)
- Venue
- British Journal of Ophthalmology
- Publisher
- BMJ
- Published
- 1985-06-01
- Volume
- 69
- Issue
- 6
- Pages
- 416-419
- ISSN
- 0007-1161 (ISSN-L)
- PMC
- PMC1040618
- OpenAlex
- W2099097011
- Cited by
- 19
- References
- 19
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Ophthalmology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Health Sciences › Medicine › Ophthalmology › Retinal and Optic Conditions
- Keywords
- retinal microangiopathy, retinal pigment epithelium, retinal microaneurysms, oral glucose tolerance, impaired glucose tolerance, retinal changes, age-related retinal changes
- MeSH terms
- Adult, Aged, Blood Glucose, Female, Fluorescein Angiography, Glucose Tolerance Test, Humans, Male, Middle Aged, Pigment Epithelium of Eye, Retinal Diseases, Retinal Vessels
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