Immunoglobulins in paired specimens of vitreous and subretinal fluids from patients with rhegmatogenous retinal detachment.
Open accessAbstract
Evidence suggests that there is a net movement of fluid through the retinal break in eyes with rhegmatogenous retinal detachment, this net movement being directed from the vitreous humour into the subretinal space. However, it remains uncertain how much fluid exchange occurs in both directions across such breaks. The concentration ratios of IgG/IgM or IgA/IgM, derived from assay of immunoglobulins in vitreous humour, subretinal fluid, and serum from a group of 19 such patients, suggest a lack of free, two-directional, fluid movement across the retinal break. Furthermore the IgG/IgM ratios for the two intraocular fluids were significantly greater than that of serum, this suggesting that these intraocular fluids are formed, at least in part, by a selective transduction of serum.
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Human vitreous fluid is thought to contain approximately 100-fold fewer antibodies than serum.
“Human vitreous fluid is thought to contain approximately 100-fold fewer antibodies than serum and it is unknown whether α-Cas9 is represented21,33.”
From Investigation of Cas9 Antibodies in the Human Eye (2022) · cites this paper as [33]
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Cites
Experimental Retinal Detachment
Pederson, J. E. (1984) · Archives of Ophthalmology · doi:10.1001/archopht.1984.01040030114048 · Cited by 60 · see citing works
CHEMICAL COMPOSITION OF SUBRETINAL FLUID
Heath, H., Beck, T. C., & Foulds, W. S. (1962) · British Journal of Ophthalmology · doi:10.1136/bjo.46.7.385 · Cited by 53 · see citing works
Clinical, biochemical, and immunoelectrophoretic study of subretinal fluid.
Chignell, A. H., Carruthers, M. E., & Rahi, A. H. S. (1971) · British Journal of Ophthalmology · doi:10.1136/bjo.55.8.525 · Cited by 45 · see citing works
Self-citationIMMUNOCHEMICAL ANALYSIS OF VITREOUS AND SUBRETINAL FLUID.
Cooper, W. C., Halbert, S. P., & Manski, W. (1963) · PubMed · Cited by 39 · see citing works
Biochemical investigation of the subretinal fluid.
Akhmeteli, L. M., Bs, K., & Petropavlovsakaja, G. A. (1975) · British Journal of Ophthalmology · doi:10.1136/bjo.59.2.70 · Cited by 22 · see citing works
Lipoproteins in Human Subretinal Fluids
Lam, K., van Heuven, W. A. J., & Ray, G. S. (1980) · Archives of Ophthalmology · doi:10.1001/archopht.1980.01020040699021 · Cited by 11 · see citing works
The lipoprotein profile and phospholipase activity of subretinal fluid
Gebhardt, D. O. E., Hogeweg, M., & Post, M. J. (1983) · Experimental Eye Research · doi:10.1016/0014-4835(83)90119-7 · Cited by 9 · see citing works
Immunelektrophorese der retroretinalen Flüssigkeit
Speiser, P. P. (2010) · Ophthalmologica · doi:10.1159/000304604 · Cited by 9 · see citing works
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Research works printed but not linked: 2
- Spieser P. Immunoelektrophores der retroretinalen Flussigkeit. Ophthalmologica 1964; 147: 291-6.
- Kaufman PL, Podos SM. The subretinal fluid in primary rhegmatogenous retinal detachment. Surv Ophthalmol 1973; 18: 100-16. 162 on August 15, 2023 by guest. Protected by copyright. http://bjo.bmj.com/ Br J Ophthalmol: first published as 10.1136/bjo.74.3.160 on 1 March 1990. Downloaded from
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Investigation of Cas9 Antibodies in the Human Eye
Toral, M. A., Charlesworth, C. T., Ng, B., Chemudupati, T., Homma, S., Nakauchi, H., Bassuk, A. G., Porteus, M. H., & Mahajan, V. B. (2022) · Nature Communications · doi:10.1038/s41467-022-28674-1 · Cited by 28 · see citing works
- Authors
- Rose, G. E., Billington, B. M., & Chignell, A. H.
- Affiliations
- St Thomas' Hospital (GB)
- ORCID
- Rose, G E
- Venue
- British Journal of Ophthalmology
- Publisher
- BMJ
- Published
- 1990-03-01
- Volume
- 74
- Issue
- 3
- Pages
- 160-162
- ISSN
- 0007-1161 (ISSN-L)
- PMC
- PMC1042039
- OpenAlex
- W2007563213
- Cited by
- 11
- References
- 8
- Citations by year
- 2025: 3 · 2022: 1 · 2020: 2 · 2019: 1 · 2016: 1 · 2015: 1 · 2012: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Ophthalmology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal and Macular Surgery
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- rhegmatogenous retinal detachment, vitreous humor, subretinal fluid, immunoglobulins
- MeSH terms
- Adolescent, Adult, Aged, Body Fluids, Female, Humans, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M, Immunoglobulin Isotypes, Male, Middle Aged, Retina, Retinal Detachment, Vitreous Body
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