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Intravitreal triamcinolone acetonide for exudative age related macular degeneration
Open accessAbstract
AIM: To evaluate the effect of intravitreal triamcinolone acetonide on the visual acuity of patients with exudative age related macular degeneration, to assess the duration of a possible effect, and to evaluate clinical side effects of the treatment. METHODS: The study included 67 patients (71 eyes) who presented with exudative age related macular degeneration of predominantly or total occult type (n = 68) or classic type (n = 3), and who received once, or repeatedly, an intravitreal injection of 25 mg of crystalline triamcinolone acetonide. Mean follow up time was 7.46 (SD 3.54) months (range 3.1-19.57 months). RESULTS: Visual acuity increased significantly (p <0.001) from 0.16 (0.11) to a mean maximum of 0.23 (0.17). Postoperative visual acuity was highest 1-3 months after the injection. 47 (66.2%) eyes gained in maximal visual acuity and 11 (15.5%) eyes lost in visual acuity. Intraocular pressure increased significantly (p <0.001) from 15.1 (3.1) mm Hg at baseline to a maximal value of 23.0 (8.25) mm Hg. At the end of follow up, intraocular pressure again decreased significantly (p<0.001) to 16.8 (4.9) mm Hg. No cases of postoperative infectious endophthalmitis, rhegmatogenous retinal detachment, or proliferative vitreoretinopathy occurred. Owing to a decrease in visual acuity after an initial increase, six patients received a second intravitreal triamcinolone acetonide injection after which visual acuity increased again in three eyes. CONCLUSIONS: Intravitreal injection of 25 mg of crystalline triamcinolone acetonide merits further study for the treatment of exudative age related macular degeneration.
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Cites
The Prevalence of Age-related Maculopathy in the Rotterdam Study
Vingerling, J. R., Dielemans, I., Hofman, A., Grobbee, D. E., Hijmering, M., Kramer, C. F. L., & de Jong, P. T. V. M. (1995) · Ophthalmology · doi:10.1016/s0161-6420(95)31034-2 · Cited by 815
Penfold, P. L., Wong, J. G., Gyory, J., & Billson, F. A. (2001) · Clinical & Experimental Ophthalmology · doi:10.1046/j.1442-9071.2001.00407.x · Cited by 97
Cited by
The Natural History and Prognosis of Neovascular Age-Related Macular Degeneration
Wong, T., Chakravarthy, U., Klein, R., Mitchell, P., Zlateva, G., Buggage, R., Fahrbach, K., Probst, C., & Sledge, I. (2008) · Ophthalmology · doi:10.1016/j.ophtha.2007.03.008 · Cited by 601
Immunological and Aetiological Aspects of Macular Degeneration
Penfold, P. L., Madigan, M. C., Gillies, M. C., & Provis, J. M. (2001) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(00)00025-2 · Cited by 460
Espinosa-Heidmann, D. G., Suner, I. J., Hernandez, E. P., Monroy, D., Csaky, K. G., & Cousins, S. W. (2003) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.03-0038 · Cited by 401
Seddon, J. M. (2005) · Archives of Ophthalmology · doi:10.1001/archopht.123.6.774 · Cited by 354
Intraocular Pressure Elevation After Intravitreal Triamcinolone Acetonide Injection
JONAS, J., DEGENRING, R., KREISSIG, I., AKKOYUN, I., & KAMPPETER, B. (2005) · Ophthalmology · doi:10.1016/j.ophtha.2004.10.042 · Cited by 323
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Metadata
- Authors
- Jonas, J. B.
- Venue
- British Journal of Ophthalmology
- Publisher
- BMJ
- Published
- 2003-04-01
- Volume
- 87
- Issue
- 4
- Pages
- 462-468
- ISSN
- 0007-1161 (ISSN-L)
- OpenAlex
- W2170353976
- Cited by
- 492
- References
- 2
- FWCI
- 83.78
- Type
- journal article
- Language
- en
- Open access
- bronze
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