The Prevalence of Age-related Maculopathy in the Rotterdam Study
Open accessAbstract
Purpose To determine the prevalence of age-related maculopathy in an elderly population in The Netherlands.Methods Fundus photographs of 6251 participants of the Rotterdam Study, a single-center prospective follow-up study in persons 55 to 98 years of age, were reviewed for the presence of drusen, pigmentary abnormalities, and atrophic or neovascular age-related macular degeneration.Results The prevalence of at least one drusen of 63 microns or larger increased from 40.8% in persons 55 to 64 years of age to 52.6% in those 85 years of age or older. Similarly, the prevalence of the following abnormalities increased significantly in these age categories: drusen of 125 microns or larger from 4.8% to 17.5%, retinal pigment epithelial hypopigmentations from 3.5% to 9.0%, and increased retinal pigment from 3.7% to 15.3%. Atrophic or neovascular age-related macular degeneration was present in 1.7% of the total population. Atrophic age-related macular degeneration increased from 0.1% in persons 55 to 64 years of age to 3.7% in those 85 years of age or older. Neovascular age-related macular degeneration increased from 0.1% to 7.4% in these age groups. No sex differences were observed for these lesions.Conclusions The prevalence of atrophic or neovascular age-related macular degeneration is 1.7%. In those 55 years of age or older, the prevalence increases strongly with age and it is similar in men and women. Neovascular age-related macular degeneration was twice as common as atrophic age-related macular degeneration. These findings suggest that age-related maculopathy may be less common in this European population than in similar populations in the United States.
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Neovascular AMD accounts for over 90% of severe central vision loss among patients with AMD.
“Neovascular AMD accounts for over 90% of severe central vision loss among patients with AMD (116, 154, 161).”
From Unraveling a Multifactorial Late-Onset Disease: From Genetic Susceptibility to Disease Mechanisms for Age-Related Macular Degeneration (2009) · cites this paper as [154]
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Self-citation
- Authors
- Vingerling, J. R., Dielemans, I., Hofman, A., Grobbee, D. E., Hijmering, M., Kramer, C. F. L., & de Jong, P. T. V. M.
- Affiliations
- Erasmus MC (NL)
- Venue
- Ophthalmology
- Publisher
- Elsevier BV
- Published
- 1995-02
- Volume
- 102
- Issue
- 2
- Pages
- 205-210
- ISSN
- 0161-6420 (ISSN-L)
- OpenAlex
- W2165062842
- Cited by
- 815
- References
- 9
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 14 · 2023: 16 · 2022: 15 · 2021: 14 · 2020: 22 · 2019: 12 · 2018: 27 · 2017: 24 · 2016: 19 · 2015: 35 · 2014: 21 · 2013: 33 · 2012: 31
- FWCI
- 21.27
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- age-related maculopathy, age-related macular degeneration, drusen, retinal pigment epithelium, retinal pigment, atrophic macular degeneration, neovascular age-related macular degeneration, prevalence, older adults, sex differences, age-related changes
- MeSH terms
- Aged, Aged, 80 and over, Female, Follow-Up Studies, Fundus Oculi, Humans, Macular Degeneration, Male, Middle Aged, Netherlands, Photography, Prospective Studies, Retinitis Pigmentosa, Retinal Drusen, Retinal Neovascularization, Prevalence
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