Biochemical evidence of myocardial fibrosis in veteran endurance athletes
Open accessAbstract
Background: Studies on exercise-induced left ventricular hypertrophy (LVH) in veteran athletes suggest the presence of abnormal diastolic filling and incomplete regression of LVH on cessation of exercise. Hypothesis: Myocardial fibrosis occurs in exercise induced LVH in veteran athletes. Aim: To document non-invasively the presence of fibrosis in veteran athletes Design: Prospective case–control study. Setting: City centre district general hospital. Participants: 45 normotensive elite veteran athletes and 45 normal sedentary subjects. Interventions: Echocardiographic assessment was made of LV mass, LV systolic and LV diastolic function. Plasma carboxyterminal propeptide of collagen type I (PICP), carboxyterminal telopeptide of collagen type I (CITP) and tissue inhibitor of matrix metalloproteinase type I (TIMP-1) were measured as markers of collagen synthesis, degradation and inhibition of degradation, respectively. Results: Veteran athletes had significant elevation in LV dimensions and calculated LV mass index (LVMI). Diastolic and systolic function was normal. Plasma PICP (259 vs 166 μg/l, p<0.001), CITP (5.4 vs 2.9 μg/l, p<0.001) and TIMP-1 (350 vs 253 ng/ml, p = 0.01) were elevated in the cohort of athletes. There was a further elevation of TIMP-1 in athletes with echocardiographic LVH, defined as an LVMI >130 g/m 2 (417 vs 266 ng/ml, p = 0.02). Conclusion: There is biochemical evidence of disruption of the collagen equilibrium favouring fibrosis in veteran athletes with LVH. This may suggest that fibrosis occurs as part of the hypertrophic process in veteran athletes.
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A study of 45 veteran elite athletes showed increased markers of myocardial fibrosis (CITP 5.4 vs. 2.9 microg/L, p < 0.001; PICP 259 vs. 166 microg/L, p < 0.001; TIMP-1 350 vs. 253 ng/mL, p = 0.01) compared to sedentary controls.
“A study including 45 veteran elite athletes showed increased markers of myocardial fibrosis, such as carboxyterminal telopeptide of collagen type I (CITP 5.4 vs. 2.9 microg/L, p < 0.001), plasma carboxyterminal propeptide of collagen type I (PICP 259 vs. 166 microg/L, p < 0.001), and tissue inhibitor of matrix metalloproteinase type I (350 vs. 253 ng/mL, p = 0.01), compared to sedentary controls [”
From Atrial Fibrillation in Elite Athletes: A Comprehensive Review of the Literature (2024) · cites this paper as [53]
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“…telopeptide of collagen type I (CITP 5.4 vs. 2.9 microg/L, p 0.001), plasma carboxyterminal propeptide of collagen type I (PICP 259 vs. 166 microg/L, p 0.001), and tissue inhibitor of matrix metalloproteinase type I (350 vs. 253 ng/mL, p = 0.01), compared to sedentary controls [53].”
BackgroundInfluential
- Authors
- Lindsay, M. M., & Dunn, F. G.
- Affiliations
- Western Infirmary (GB)
- Stobhill Hospital (GB)
- Corresponding author
- Lindsay, M Mitchell
- ORCID
- Lindsay, M Mitchell
- Venue
- British Journal of Sports Medicine
- Publisher
- BMJ
- Published
- 2007-02-20
- Volume
- 41
- Issue
- 7
- Pages
- 447-452
- ISSN
- 0306-3674 (ISSN-L)
- 1473-0480
- PMC
- PMC2465358
- OpenAlex
- W2112971521
- Cited by
- 96
- References
- 0
- Citations by year
- 2026: 3 · 2024: 1 · 2023: 6 · 2022: 4 · 2020: 3 · 2019: 5 · 2018: 15 · 2017: 5 · 2016: 10 · 2015: 5 · 2014: 8 · 2013: 7 · 2012: 5
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Sports Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Keywords
- myocardial fibrosis, older athletes, endurance athletes, C-terminal telopeptide of type I collagen, TIMP-1, left ventricular mass, left ventricular function, collagen synthesis and degradation
- MeSH terms
- Aged, Diastole, Echocardiography, Electrocardiography, Fibrosis, Heart Ventricles, Humans, Male, Middle Aged, Myocardium, Physical Endurance, Prospective Studies, Sports, Systole, Cohort Studies, Case-Control Studies, Hypertrophy, Left Ventricular, Tissue Inhibitor of Metalloproteinase-1, Collagen Type I
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