Strenuous endurance exercise: is more better for everyone? Our genes won't tell us
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Introduction Analysis of faecal calprotectin (FC) is a non-invasive method for differentiating IBS from IBD. As a screening test, a normal FC has been employed to support a diagnosis of IBS, thereby avoiding invasive endoscopy in the patient cohort. We sought to investigate the diagnostic yield on subsequent colonoscopy in patients with mildly elevated FC and lower GI symptoms. Methods Between November 2009 and November 2010, all patients with a FC value of 50–100 μg/g of stool (normal 100 ug/g stool, were known cases of IBD, had a history of NSAID intake, positive stool cultures, or any “alarm” GI symptoms. A similar cohort was identified with age & sex matched controls with FC values <50 μg/g. All the patients who did not go on to have a complete colonoscopy were removed from further analysis. Patients9 records were analysed electronically using the NHS Great Glasgow & Clyde Clinical Portal. Results 216 patients were identified with a FC of 50–100 μg/g. After exclusion criteria, 158 patients remained. Of these 82 underwent complete colonoscopy (mean age 36.7, M:F 1:2.2) which was abnormal in only six cases (three cases of a single adenoma<10 mm, one diverticulosis, one helminth infection & one non-specific acute inflammation). 280 patients were identified with a FC<50 μg/g. After exclusion criteria, 176 patients remained. Of these 65 underwent complete colonoscopy (mean age 36.6, M:F 1:2.3) which was abnormal in only eight cases (six cases of non-specific acute inflammation…
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Intense endurance exercise may be associated with an excess in arrhythmic disorders.
“However, there is also emerging evidence that intense endurance exercise may be associated with an excess in arrhythmic disorders, the mechanisms for which remain unexplained.38 -41”
From Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes (2012) · cites this paper as [39]
Cites
Heidbüchel, H. (2003) · European Heart Journal · doi:10.1016/s0195-668x(03)00282-3 · Cited by 395 · see citing works
Self-citationRemodeling of Left Ventricular Hypertrophy in Elite Athletes After Long-Term Deconditioning
Pelliccia, A., Maron, B. J., De Luca, R., Di Paolo, F. M., Spataro, A., & Culasso, F. (2002) · Circulation · doi:10.1161/hc0802.104534 · Cited by 390 · see citing works
Relation of vigorous exercise to risk of atrial fibrillation
Aizer, A., Gaziano, J. M., Cook, N. R., Manson, J. E., Buring, J. E., & Albert, C. M. (2009) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.01.374 · Cited by 383 · cited 1× · see citing works
“There is increasing evidence that strenuous endurance exercise is associated with an increased prevalence of atrial fibrillation (AF). Even within ranges of exercise below those practised by athletes, a U-shaped exercise response curve has been described whereby mild exercise is associated with a lower incidence of AF…”
BackgroundBiffi, A., Pelliccia, A., Verdile, L., Fernando, F., Spataro, A., Caselli, S., Santini, M., & Maron, B. J. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01977-0 · Cited by 315 · see citing works
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Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes
La Gerche, A., Burns, A. T., Mooney, D. J., Inder, W. J., Taylor, A. J., Bogaert, J., MacIsaac, A. I., Heidbüchel, H., & Prior, D. L. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr397 · Cited by 776 · see citing works
Self-citationAtrial fibrillation in athletes and the interplay between exercise and health
Gerche, A. L., & Schmied, C. M. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht265 · Cited by 78 · see citing works
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- Authors
- La Gerche, A., Prior, D. L., & Heidbüchel, H.
- Affiliations
- The University of Melbourne (AU)
- KU Leuven (BE)
- Venue
- British Journal of Sports Medicine
- Publisher
- BMJ
- Published
- 2010-12-27
- Volume
- 45
- Issue
- 3
- Pages
- 162-164
- ISSN
- 0306-3674 (ISSN-L)
- 1473-0480
- OpenAlex
- W2110249068
- Cited by
- 9
- References
- 4
- Citations by year
- 2019: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Sports Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- fecal calprotectin, inflammatory bowel disease, irritable bowel syndrome, colonoscopy, diagnostic yield, non-invasive screening, diverticulosis, adenoma, lower gastrointestinal symptoms, negative predictive value
- MeSH terms
- Humans, Life Expectancy, Physical Endurance, Physical Fitness, Exercise
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