Remodeling of Left Ventricular Hypertrophy in Elite Athletes After Long-Term Deconditioning
Abstract
Background The clinical significance and long-term consequences of left ventricular (LV) hypertrophy associated with intensive athletic conditioning remain unresolved. Methods and results We prospectively evaluated 40 elite male athletes who had shown marked LV cavity enlargement of > or = 60 mm, wall thickness of > or = 13 mm, or both in a longitudinal fashion with serial echocardiograms, initially at peak training (age 24 +/- 4 years) and subsequently after a long-term deconditioning period (1 to 13 years; mean, 5.6 +/- 3.8). After detraining, LV cavity dimension decreased by 7% (61.2 +/- 2.9 to 57.2 +/- 3.1 mm; P or = 60 mm) in 9 athletes (22%); in contrast, wall thickness returned to normal in each athlete. Multiple regression analysis demonstrated that approximately 50% of the incomplete reduction in cavity dimension was explained by increased body weight and recreational physical activity performed during the follow-up period. No athlete had developed cardiac symptoms, impaired exercise performance, or evidence of LV dysfunction. Conclusions LV remodeling was evident after long-term detraining, with significant reduction in cavity size and normalization of wall thickness. Resolution of cavity enlargement was, however, incomplete in most cases, and substantial chamber dilatation persisted in >20% of athletes. The possibility that this residual LV hypertrophy, apparently part of the athlete's heart syndrome, may have future long-term clinical implications in some individu…
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Even after many years of detraining, cardiac dilation may not completely regress in elite athletes.
“Even after many years of detraining, cardiac dilation may not completely regress in elite athletes 16,17”
From Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes (2012) · cites this paper as [16]
Cites
Sahn, D. J., DeMaria, A. N., KISSLO, J. A., & Weyman, A. E. (1978) · Circulation · doi:10.1161/01.cir.58.6.1072 · Cited by 7,430 · see citing works
Echocardiographic assessment of left ventricular hypertrophy: Comparison to necropsy findings
Devereux, R. B., Alonso, D. R., Lutas, E. M., Gottlieb, G. J., Campo, E., Sachs, I., & Reichek, N. (1986) · The American Journal of Cardiology · doi:10.1016/0002-9149(86)90771-x · Cited by 6,226 · see citing works
Levy, D., Garrison, R. J., Savage, D. D., Kannel, W. B., & Castelli, W. P. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005313222203 · Cited by 5,699 · see citing works
Hypertensive, Y., & Chin, K. (1982) · Springer eBooks · doi:10.1007/978-3-642-68282-7 · Cited by 1,757 · see citing works
Sudden Death in Young Competitive Athletes: Clinical, Demographic, and Pathological Profiles
Maron, B. J. (1996) · JAMA · doi:10.1001/jama.1996.03540030033028 · Cited by 1,693 · see citing works
Self-citationPluim, B. M., Zwinderman, A. H., van der Laarse, A., & van der Wall, E. E. (2000) · Circulation · doi:10.1161/01.cir.101.3.336 · Cited by 1,110 · see citing works
The Upper Limit of Physiologic Cardiac Hypertrophy in Highly Trained Elite Athletes
Pelliccia, A., Maron, B. J., Spataro, A., Proschan, M. A., & Spirito, P. (1991) · New England Journal of Medicine · doi:10.1056/nejm199101313240504 · Cited by 1,014 · see citing works
Self-citationEchocardiographic measurements in normal subjects from infancy to old age.
Henry, W. L., Gardin, J. M., & Ware, J. H. (1980) · Circulation · doi:10.1161/01.cir.62.5.1054 · Cited by 632 · see citing works
Physiologic Left Ventricular Cavity Dilatation in Elite Athletes
Pelliccia, A., Culasso, F., Paolo, F. M. D., & Maron, B. J. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-1-199901050-00005 · Cited by 581 · see citing works
Self-citationScharhag, J., Schneider, G. K., Urhausen, A. J. P., Rochette, V., Kramann, B. H., & Kindermann, W. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02478-6 · Cited by 525 · see citing works
Structural features of the athlete heart as defined by echocardiography
Maron, B. J. (1986) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(86)80282-0 · Cited by 516 · see citing works
Self-citationSpirito, P., Pelliccia, A., Proschan, M. A., Granata, M., Spataro, A., Bellone, P., Caselli, G., Biffi, A., Vecchio, C., & Maron, B. J. (1994) · The American Journal of Cardiology · doi:10.1016/0002-9149(94)90439-1 · Cited by 411 · see citing works
Self-citationCardiac Disease in Young Trained Athletes
Maron, B. J., Pelliccia, A., & Spirito, P. (1995) · Circulation · doi:10.1161/01.cir.91.5.1596 · Cited by 387 · see citing works
Self-citationMaron, B. J. (1997) · The Lancet · doi:10.1016/s0140-6736(97)01282-8 · Cited by 368 · see citing works
Self-citationSports-related and non-sports-related sudden cardiac death in young adults
BURKE, A. P., Farb, A. A., Virmani, R., Goodin, J. C., & Smialek, J. E. (1991) · American Heart Journal · doi:10.1016/0002-8703(91)90727-y · Cited by 358 · see citing works
Athlete's heart in women. Echocardiographic characterization of highly trained elite female athletes
Pelliccia, A. (1996) · JAMA · doi:10.1001/jama.276.3.211 · Cited by 327 · see citing works
Self-citationPelliccia, A. (1996) · JAMA · doi:10.1001/jama.1996.03540030045030 · Cited by 280 · see citing works
Self-citationVasan, R. S., Larson, M. G., Levy, D., Evans, J. C., & Benjamin, E. J. (1997) · Circulation · doi:10.1161/01.cir.96.6.1863 · Cited by 248 · see citing works
Pelliccia, A., & Maron, B. J. (1995) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)80421-4 · Cited by 222 · see citing works
Self-citationMaron, B. J., Pelliccia, A., Spataro, A., & Granata, M. (1993) · Heart · doi:10.1136/hrt.69.2.125 · Cited by 209 · see citing works
Self-citationRegulation of cardiovascular collagen synthesis by mechanical load
Bishop, J. E. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00021-8 · Cited by 177 · see citing works
Martin, W. H., Coyle, E. F., Bloomfield, S. A., & Ehsani, A. A. (1986) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(86)80215-7 · Cited by 148 · see citing works
Lauer, M. S., Evans, J. C., & Levy, D. A. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)90052-z · Cited by 141 · see citing works
Angiotensinogen gene M235T polymorphism predicts left ventricular hypertrophy in endurance athletes
Karjalainen, J., Kujala, U. M., Stolt, A., Mäntysaari, M., Viitasalo, M. T., Kainulainen, K., & KONTULA, K. K. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00199-0 · Cited by 133 · see citing works
Gayazzi, A., Maria, R. D., Renosto, G., Moro, A., Borgia, M., Caroli, A., Castelli, G., Ciaccheri, M., Pavan, D., Vita, C. D., et al. (1993) · American Heart Journal · doi:10.1016/0002-8703(93)90020-a · Cited by 92 · see citing works
Lauer, M. S., Larson, M. G., & Levy, D. A. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00275-0 · Cited by 91 · see citing works
Athletic left ventricular hypertrophy: long-term studies are required
McCann, G. P. (2000) · European Heart Journal · doi:10.1053/euhj.1999.1783 · Cited by 21 · see citing works
Mechanism of Pericardial Expansion with Cardiac Enlargement
Kardon, D. E., Borczuk, A., & Factor, S. M. (2000) · Cardiovascular Pathology · doi:10.1016/s1054-8807(99)00029-0 · Cited by 9 · see citing works
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Cited by
Sorted by citations
2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy
Authors/Task Force members, Elliott, P. M., Anastasakis, A., Borger, M. A., Borggrefe, M., Cecchi, F., Charron, P., Hagege, A. A., Lafont, A., Limongelli, G., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu284 · Cited by 4,332 · see citing works
Sudden Death in Young Athletes
Maron, B. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmra022783 · Cited by 1,394 · see citing works
Self-citationExercise-induced right ventricular dysfunction and structural remodelling in endurance athletes
La Gerche, A., Burns, A. T., Mooney, D. J., Inder, W. J., Taylor, A. J., Bogaert, J., MacIsaac, A. I., Heidbüchel, H., & Prior, D. L. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr397 · Cited by 776 · see citing works
Maron, B. J., & Pelliccia, A. (2006) · Circulation · doi:10.1161/circulationaha.106.613562 · Cited by 746 · see citing works
Self-citationInside the brain of an elite athlete: the neural processes that support high achievement in sports
Yarrow, K., Brown, P., & Krakauer, J. W. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2672 · Cited by 643 · see citing works
Cardiac arrhythmogenic remodeling in a rat model of long-term intensive exercise training
Benito, B., Gay-Jordi, G., Serrano-Mollar, A., Guasch, E., Shi, Y., Tardif, J.-C., Brugada, J., Nattel, S., & Mont, L. (2011) · Circulation · doi:10.1161/circulationaha.110.938282 · Cited by 478 · see citing works
Potential Adverse Cardiovascular Effects From Excessive Endurance Exercise
O’Keefe, J. H., Patil, H., Lavie, C. J., Magalski, A., Vogel, R. A., & McCullough, P. A. (2012) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2012.04.005 · Cited by 471 · see citing works
Narula, S., Shameer, K., Omar, A. M. S., Dudley, J. T., & Sengupta, P. P. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.08.062 · Cited by 414 · see citing works
Fagard, R. H. (2003) · Heart · doi:10.1136/heart.89.12.1455 · Cited by 371 · see citing works
Pelliccia, A., Caselli, S., Sharma, S., Basso, C., Bax, J. J., Corrado, D., D’Andrea, A., D’Ascenzi, F., Paolo, F. M. D., Edvardsen, T., et al. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx532 · Cited by 373 · see citing works
Self-citationCardiac Remodeling in Response to 1 Year of Intensive Endurance Training
Arbab‐Zadeh, A., Perhonen, M. A., Howden, E. J., Peshock, R. M., Zhang, R., Adams-Huet, B., Haykowsky, M. J., & Levine, B. D. (2014) · Circulation · doi:10.1161/circulationaha.114.010775 · Cited by 365 · see citing works
2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy
Elliot, P. M., Anastasakis, A., Borger, M. A., Borggrefe, M., Cecchi, F., Charron, P., Hagège, A. A., Lafont, A. M., Limongelli, G., Mahrholdt, H., et al. (2014) · Kardiologia Polska · doi:10.5603/kp.2014.0212 · Cited by 342 · see citing works
The Fuzzy Logic of Physiological Cardiac Hypertrophy
Dorn, G. W. (2007) · Hypertension · doi:10.1161/hypertensionaha.106.079426 · Cited by 333 · see citing works
Atrial Fibrillation Promotion by Endurance Exercise
Guasch, E., Benito, B., Qi, X., Cifelli, C., Naud, P., Shi, Y., Mighiu, A., Tardif, J.-C., Tadevosyan, A., Chen, Y., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.01.091 · Cited by 302 · see citing works
Athlete's Heart and Cardiovascular Care of the Athlete
Baggish, A. L., & Wood, M. J. (2011) · Circulation · doi:10.1161/circulationaha.110.981571 · Cited by 294 · see citing works
Influence of Physical Activity on Hypertension and Cardiac Structure and Function
Hegde, S. M., & Solomon, S. D. (2015) · Current Hypertension Reports · doi:10.1007/s11906-015-0588-3 · Cited by 286 · see citing works
Galderisi, M., Cardim, N. M., D’Andrea, A., Bruder, O., Cosyns, B., Davin, L., Donal, E., Edvardsen, T., Freitas, A., Habib, G., et al. (2015) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jeu323 · Cited by 258 · see citing works
Ericsson, K. A. (2007) · International journal of sport psychology · Cited by 239 · see citing works
Toward a Science of Exceptional Achievement
Ericsson, K. A., Nandagopal, K., & Roring, R. W. (2009) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1393.001 · Cited by 229 · see citing works
Pregnancy as a cardiac stress model
Chung, E., & Leinwand, L. A. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu013 · Cited by 227 · see citing works
Spence, A. L., Naylor, L. H., Carter, H. H., Buck, C. L., Dembo, L. G., Murray, C. P. J., Watson, P., Oxborough, D., George, K., & GREEN, D. J. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.217125 · Cited by 223 · see citing works
Persistent and reversible cardiac dysfunction among amateur marathon runners
Neilan, T. G., Yoerger, D. M., Douglas, P. S., Marshall, J. E., Halpern, E. F., Lawlor, D., Picard, M. H., & Wood, M. J. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi813 · Cited by 206 · see citing works
Prior, D., & Gerche, A. L. (2012) · Heart · doi:10.1136/heartjnl-2011-301329 · Cited by 196 · see citing works
Exercise-Induced Cardiovascular Adaptations and Approach to Exercise and Cardiovascular Disease
Martinez, M. W., Kim, J. H., Shah, A. B., Phelan, D. M. J., Emery, M. S., Wasfy, M. M., Fernández, A. B., Bunch, T. J., Dean, P. N., Danielian, A., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.08.003 · Cited by 193 · see citing works
Aschar-Sobbi, R., Izaddoustdar, F., Korogyi, A. S., Wang, Q., Farman, G. P., Yang, F., Yang, W., Dorian, D., Simpson, J. A., Tuomi, J. M., et al. (2015) · Nature Communications · doi:10.1038/ncomms7018 · Cited by 185 · see citing works
Effect of Sex and Sporting Discipline on LV Adaptation to Exercise
Finocchiaro, G., Dhutia, H., D’Silva, A., Malhotra, A., Steriotis, A. K., Millar, L. M., Prakash, K., Narain, R., Papadakis, M., Sharma, R., et al. (2016) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2016.08.011 · Cited by 184 · see citing works
Ericsson, K. A. (2014) · Intelligence · doi:10.1016/j.intell.2013.12.001 · Cited by 178 · see citing works
The Athlete's Heart vs. the Failing Heart: Can Signaling Explain the Two Distinct Outcomes?
Weeks, K. L., & McMullen, J. R. (2011) · Physiology · doi:10.1152/physiol.00043.2010 · Cited by 174 · see citing works
The coronary circulation and blood flow in left ventricular hypertrophy
Camici, P. G., Olivotto, I., & Rimoldi, O. E. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.08.028 · Cited by 167 · see citing works
Long-Term Clinical Consequences of Intense, Uninterrupted Endurance Training in Olympic Athletes
Pelliccia, A., Kinoshita, N., Pisicchio, C., Quattrini, F., DiPaolo, F. M., Ciardo, R., Di Giacinto, B., Guerra, E., De Blasiis, E., Casasco, M., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.10.068 · Cited by 159 · see citing works
Self-citationLeft ventricular hypertrophy in athletes
Rawlins, J., Bhan, A., & Sharma, S. (2009) · European Journal of Echocardiography · doi:10.1093/ejechocard/jep017 · Cited by 158 · see citing works
Weeks, K. L., Gao, X., Du, X., Boey, E. J. H., Matsumoto, A., Bernardo, B. C., Kiriazis, H., Cemerlang, N., Tan, J. W., Tham, Y. K., et al. (2012) · Circulation Heart Failure · doi:10.1161/circheartfailure.112.966622 · Cited by 147 · see citing works
Maron, B. J. (2009) · British Journal of Sports Medicine · doi:10.1136/bjsm.2008.054726 · Cited by 143 · see citing works
Self-citationGates, P. E. (2003) · European Heart Journal · doi:10.1016/j.ehj.2003.09.026 · Cited by 140 · see citing works
Zaidi, A., Sheikh, N., Jongman, J. K., Gati, S., Panoulas, V. F., Carr‐White, G., Papadakis, M., Sharma, R. K., Behr, E. R., & Sharma, S. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.04.035 · Cited by 140 · see citing works
From Left Ventricular Hypertrophy to Dysfunction and Failure
Lazzeroni, D., Rimoldi, O. E., & Camici, P. G. (2016) · Circulation Journal · doi:10.1253/circj.cj-16-0062 · Cited by 137 · see citing works
Petersen, S. E., Selvanayagam, J. B., Francis, J. M., Myerson, S. G., Wiesmann, F., Robson, M. D., Östman‐Smith, I., Casadei, B., Watkins, H. C., & Neubauer, S. (2005) · Journal of Cardiovascular Magnetic Resonance · doi:10.1081/jcmr-200060631 · Cited by 137 · see citing works
Diagnosis, pathophysiology, and management of exercise-induced arrhythmias
Guasch, E., & Mont, L. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.173 · Cited by 134 · see citing works
Pelliccia, A., Maron, M. S., & Maron, B. J. (2012) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2012.01.003 · Cited by 134 · see citing works
Self-citationKemi, O. J., Haram, P. M., Wisløff, U., & Ellingsen, Ø. (2004) · Circulation · doi:10.1161/01.cir.0000129308.04757.72 · Cited by 134 · see citing works
Ericsson, K. A. (2013) · British Journal of Sports Medicine · doi:10.1136/bjsports-2012-091767 · Cited by 133 · see citing works
Can Intensive Exercise Harm the Heart?
Gerche, A. L., & Heidbüchel, H. (2014) · Circulation · doi:10.1161/circulationaha.114.008141 · Cited by 132 · see citing works
Baggish, A. L., Battle, R. W., Beckerman, J. G., Bové, A. A., Lampert, R. J., Levine, B. D., Link, M. S., Martinez, M. W., Molossi, S. M., Salerno, J. C., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.08.055 · Cited by 120 · see citing works
Molecular Mechanisms of Cardiac Remodeling and Regeneration in Physical Exercise
Schüttler, D., Clauss, S., Weckbach, L. T., & Brunner, S. (2019) · Cells · doi:10.3390/cells8101128 · Cited by 117 · see citing works
The Athlete’s Heart—Challenges and Controversies
Gerche, A. L., Wasfy, M. M., Brosnan, M. J., Claessen, G., Fatkin, D., Heidbüchel, H., Baggish, A. L., & Kovacic, J. C. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.07.014 · Cited by 109 · see citing works
The effects of endurance exercise on the heart: panacea or poison?
Parry-Williams, G., & Sharma, S. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0354-3 · Cited by 102 · see citing works
Mechanisms of Cardiac Contraction and Relaxation
Opie, L. H., & Hasenfuss, G. P. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0398-6.00024-x · Cited by 97 · see citing works
Athlete's Heart: The Potential for Multimodality Imaging to Address the Critical Remaining Questions
Gerche, A. L., Taylor, A. J., & Prior, D. (2009) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2008.12.011 · Cited by 95 · see citing works
Fibroblast-mediated pathways in cardiac hypertrophy
Fujiu, K., & Nagai, R. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.01.013 · Cited by 93 · see citing works
Athletic Cardiac Remodeling in US Professional Basketball Players
Engel, D. J., Schwartz, A. J., & Homma, S. (2016) · JAMA Cardiology · doi:10.1001/jamacardio.2015.0252 · Cited by 93 · see citing works
Exercise effects on cardiovascular disease: from basic aspects to clinical evidence
Sanchis‐Gomar, F., Lavie, C. J., Marín-Puyalto, J., Pérez-Quilis, C., Eijsvogels, T. M. H., O’Keefe, J. H., Perez, M. V., & Blair, S. N. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab272 · Cited by 99 · see citing works
Hurwitz, B. E., Coryell, V., Parker, M., Martin, P., LaPerriere, A. R., Klimas, N. G., Sfakianakis, G. N., & Bilsker, M. (2009) · Clinical Science · doi:10.1042/cs20090055 · Cited by 92 · see citing works
Run for your life … at a comfortable speed and not too far
O’Keefe, J. H., & Lavie, C. J. (2012) · Heart · doi:10.1136/heartjnl-2012-302886 · Cited by 93 · see citing works
The endurance athletes heart: acute stress and chronic adaptation
George, K., Whyte, G. P., Green, D. J., Oxborough, D., Shave, R., Gaze, D. C., & Somauroo, J. D. (2012) · British Journal of Sports Medicine · doi:10.1136/bjsports-2012-091141 · Cited by 91 · see citing works
Atrial fibrillation in highly trained endurance athletes — Description of a syndrome
Sanchis-Gomar, F., Perez-Quilis, C., Lippi, G., Cervellin, G., Leischik, R., Löllgen, H., Serrano-Ostáriz, E., & Lucia, A. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.10.047 · Cited by 95 · see citing works
Ericsson, K. A., & Towne, T. J. (2010) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.47 · Cited by 87 · see citing works
Mechanisms of exercise‐induced improvements in the contractile apparatus of the mammalian myocardium
Kemi, O. J., & Wisløff, U. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02132.x · Cited by 85 · see citing works
Scharf, M., Brem, M. H., Wilhelm, M., Schoepf, U. J., Uder, M., & Lell, M. (2010) · Radiology · doi:10.1148/radiol.10092377 · Cited by 86 · see citing works
Exercise cardiac magnetic resonance to differentiate athlete’s heart from structural heart disease
Claessen, G., Schnell, F., Bogaert, J. G., Claeys, M., Pattyn, N., Buck, F. D., Dymarkowski, S., Claus, P., Carré, F., Cleemput, J. V., et al. (2018) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jey050 · Cited by 74 · see citing works
Hansen, M. W., & Merchant, N. (2007) · American Journal of Roentgenology · doi:10.2214/ajr.07.2287 · Cited by 72 · see citing works
Moderate Physical Activity in Healthy Adults Is Associated With Cardiac Remodeling
Dawes, T. J. W., Corden, B., Cotter, S., de Marvao, A., Walsh, R., Ware, J. S., Cook, S. A., & O’Regan, D. P. (2016) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.116.004712 · Cited by 69 · see citing works
Cardiovascular adaptation in athletes
Kovacs, R. J., & Baggish, A. L. (2015) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2015.04.003 · Cited by 66 · see citing works
Bocalini, D. S., Carvalho, E. V. A., de Sousa, A. F. M., Levy, R. F., & Tucci, P. J. F. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1406-x · Cited by 64 · see citing works
Perseghin, G., COBELLI, F. D., Esposito, A., Lattuada, G., Terruzzi, I. M., Torre, A. L., Belloni, E., Canu, T., Scifo, P., Maschio, A. D., et al. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.06.039 · Cited by 63 · see citing works
Scharf, M., Brem, M. H., Wilhelm, M., Schoepf, U. J., Uder, M., & Lell, M. (2010) · American Heart Journal · doi:10.1016/j.ahj.2010.02.027 · Cited by 61 · see citing works
Cardiac damage in athlete’s heart: When the “supernormal” heart fails!
Carbone, A., D’Andrea, A., Riegler, L., Scarafile, R., Pezzullo, E., Martone, F., America, R., Liccardo, B., Galderisi, M., Bossone, E., et al. (2017) · World Journal of Cardiology · doi:10.4330/wjc.v9.i6.470 · Cited by 63 · see citing works
D’Andrea, A., D’Andrea, L., Caso, P., Scherillo, M., Zeppilli, P., & Calabrò, R. (2006) · Echocardiography · doi:10.1111/j.1540-8175.2006.00186.x · Cited by 60 · see citing works
Knöll, R., Iaccarino, G., Tarone, G., Hilfiker‐Kleiner, D., Bauersachs, J. K., Leite-Moreira, A. F., Sugden, P. H., & Balligand, J. (2011) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfr071 · Cited by 59 · see citing works
Sudden Death in the Young: Information for the Primary Care Provider
Erickson, C. C., Salerno, J. C., Berger, S., Campbell, R., Cannon, B. C., Christiansen, J., Moffatt, K. A., Pflaumer, A., Snyder, C. S., Srinivasan, C., et al. (2021) · PEDIATRICS · doi:10.1542/peds.2021-052044 · Cited by 60 · see citing works
Taking pressure off the heart: the ins and outs of atrophic remodelling
Baskin, K. K., & Taegtmeyer, H. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr060 · Cited by 60 · see citing works
Differentiating Athlete’s Heart From Cardiomyopathies — The Left Side
Brosnan, M. J., & Rakhit, D. J. (2018) · Heart Lung and Circulation · doi:10.1016/j.hlc.2018.04.297 · Cited by 58 · see citing works
Exercise-induced arrhythmogenic right ventricular cardiomyopathy: fact or fallacy?
Sharma, S., & Zaidi, A. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr436 · Cited by 58 · see citing works
Can Intense Endurance Exercise Cause Myocardial Damage and Fibrosis?
Gerche, A. L. (2013) · Current Sports Medicine Reports · doi:10.1249/jsr.0b013e318287488a · Cited by 56 · see citing works
Echocardiographic Measurement of Left Atrial Strain ― A Key Requirement in Clinical Practice ―
Sun, B. J., & Park, J.-H. (2021) · Circulation Journal · doi:10.1253/circj.cj-21-0373 · Cited by 56 · see citing works
Echocardiography: Profiling of the Athlete’s Heart
Paterick, T. E., Gordon, T., & Spiegel, D. (2014) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2014.06.008 · Cited by 54 · see citing works
Right Heart Structural and Functional Remodeling in Athletes
D’Andrea, A., Gerche, A. L., Golia, E., Teske, A. J., Bossone, E., Russo, M. G., Calabrò, R., & Baggish, A. L. (2014) · Echocardiography · doi:10.1111/echo.12226 · Cited by 54 · see citing works
Cardiac effects of detraining in athletes: A narrative review
Petek, B. J., Groezinger, E. Y., Pedlar, C. R., & Baggish, A. L. (2021) · Annals of Physical and Rehabilitation Medicine · doi:10.1016/j.rehab.2021.101581 · Cited by 54 · see citing works
Serum troponin I levels in hyperthyroid cats before and after treatment with radioactive iodine
Connolly, D. J., Guitián, J., Boswood, A., & Neiger, R. (2005) · Journal of Feline Medicine and Surgery · doi:10.1016/j.jfms.2005.01.002 · Cited by 53 · see citing works
Associations of Body Composition with Blood Pressure and Hypertension
Ye, S., Zhu, C., Chen, W., Yang, M., Zheng, W., Gan, D., & Zhu, S. (2018) · Obesity · doi:10.1002/oby.22291 · Cited by 53 · see citing works
Khine, H., Steding‐Ehrenborg, K., Hastings, J. L., Kowal, J. L., Daniels, J. D., Page, R. L., Goldberger, J. J., Ng, J., ADAMS-HUET, B. A., Bungo, M. W., et al. (2018) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.117.005959 · Cited by 53 · see citing works
Papadakis, M., Wilson, M. G., Ghani, S., Kervio, G., Carré, F., & Sharma, S. (2012) · British Journal of Sports Medicine · doi:10.1136/bjsports-2012-091127 · Cited by 52 · see citing works
The athlete’s heart: insights from echocardiography
Flanagan, H., Cooper, R. M., George, K., Augustine, D. X., Malhotra, A., Paton, M. F., Robinson, S., & Oxborough, D. (2023) · Echo Research and Practice · doi:10.1186/s44156-023-00027-8 · Cited by 51 · see citing works
Giuşcă, S., Steen, H., Montenbruck, M., Patel, A. R., Pieske, B. M., Erley, J., Kelle, S., & Korosoglou, G. (2021) · Journal of Cardiovascular Magnetic Resonance · doi:10.1186/s12968-021-00775-8 · Cited by 51 · see citing works
Hypertrophic Cardiomyopathy in Athletes
Malhotra, A., & Sharma, S. (2017) · European Cardiology Review · doi:10.15420/ecr.2017:12:1 · Cited by 47 · see citing works
Tsuda, T. (2021) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd8100122 · Cited by 47 · see citing works
Naylor, L. H., Arnolda, L., Deague, J. A., Playford, D. A., Maurogiovanni, A., O’Driscoll, G., & GREEN, D. J. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.078360 · Cited by 47 · see citing works
Endurance Exercise and the Heart: Friend or Foe?
Sanchis‐Gomar, F., Pérez, L. M., Joyner, M. J., Löllgen, H., & Lucía, A. (2015) · Sports Medicine · doi:10.1007/s40279-015-0434-4 · Cited by 44 · see citing works
Impact of ethnicity on cardiac adaptation to exercise
Sheikh, N., & Sharma, S. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.15 · Cited by 44 · see citing works
Napolitano, C., Bloise, R., & Priori, S. G. (2006) · Journal of Cardiovascular Medicine · doi:10.2459/01.jcm.0000219317.12504.5f · Cited by 44 · see citing works
Luthi, P., ZUBER, M., Ritter, M., Oechslin, E., Jenni, R., Seifert, B., Baldesberger, S., & Jost, C. H. A. (2007) · European Journal of Echocardiography · doi:10.1016/j.euje.2007.03.001 · Cited by 43 · see citing works
Competitive Sports and the Heart
Scharhag, J., Löllgen, H., & Kindermann, W. (2013) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2013.0014 · Cited by 43 · see citing works
Sudden Death in Competitive Athletes
Pigozzi, F., & Rizzo, M. (2008) · Clinics in Sports Medicine · doi:10.1016/j.csm.2007.09.004 · Cited by 41 · see citing works
D’Ascenzi, F., Pelliccia, A., Cameli, M., Lisi, M., Natali, B. M., Focardi, M., Giorgi, A., D’Urbano, G., Causarano, A., Bonifazi, M., et al. (2013) · European Journal of Preventive Cardiology · doi:10.1177/2047487313505820 · Cited by 42 · see citing works
Self-citationWeiner, R. B., Wang, F., Berkstresser, B. D., Kim, J., Wang, T. J., Lewis, G. D., Hutter, A. M., Picard, M. H., & Baggish, A. L. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.01.057 · Cited by 42 · see citing works
Left Ventricular Hypertrophy in Athletes: Morphologic Features and Clinical Correlates
Atchley, A. E., & Douglas, P. S. (2007) · Cardiology Clinics · doi:10.1016/j.ccl.2007.06.009 · Cited by 42 · see citing works
Falcão‐Pires, I., Ferreira, A. F., Trindade, F., Bertrand, L., Ciccarelli, M., Visco, V., Dawson, D. K., Hamdani, N., Laake, L. W. V., Lezoualc’h, F., et al. (2024) · European Journal of Heart Failure · doi:10.1002/ejhf.3264 · Cited by 43 · see citing works
Brancaccio, M., Mennitti, C., Cesaro, A., Fimiani, F., Moscarella, E., Caiazza, M., Gragnano, F., Ranieri, A., D’Alicandro, G., Tinto, N., et al. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17249424 · Cited by 40 · see citing works
Turvey-Haigh, L., Augustine, D. X., Robinson, S., Oxborough, D., Stout, M., Smith, N., Harkness, A., Williams, L. K., Steeds, R. P., & Bradlow, W. M. (2021) · Echo Research and Practice · doi:10.1530/erp-20-0042 · Cited by 40 · see citing works
The Role of Multimodality Imaging in Athlete’s Heart Diagnosis: Current Status and Future Directions
D’Andrea, A., Sperlongano, S., Russo, V., D’Ascenzi, F., Benfari, G., Renon, F., Palermi, S., Ilardi, F., Giallauria, F., Limongelli, G., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10215126 · Cited by 40 · see citing works
Cardiovascular response to prescribed detraining among recreational athletes
Pedlar, C. R., Brown, M. G., Shave, R., Otto, J. M., Drane, A. L., Michaud-Finch, J., Contursi, M. E., Wasfy, M. M., Hutter, A. M., Picard, M. H., et al. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00911.2017 · Cited by 39 · see citing works
- Authors
- Pelliccia, A., Maron, B. J., De Luca, R., Di Paolo, F. M., Spataro, A., & Culasso, F.
- Affiliations
- Minneapolis Heart Institute Foundation (US)
- From the Institute of Sports Science, Department of Medicine (A.P., R.D.L., F.M.D.P., A.S.), Rome, Italy; Minneapolis Heart Institute Foundation (B.J.M.), Minneapolis, Minn; and Department of Experimental Medicine, University La Sapienza (F.C.), Rome, Italy.
- Venue
- Circulation
- Published
- 2002-02-26
- Volume
- 105
- Issue
- 8
- Pages
- 944-949
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2009338965
- Cited by
- 390
- References
- 28
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 15 · 2023: 19 · 2022: 17 · 2021: 26 · 2020: 19 · 2019: 12 · 2018: 13 · 2017: 13 · 2016: 28 · 2015: 23 · 2014: 17 · 2013: 10 · 2012: 26
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Minneapolis Heart Institute Foundation
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- left ventricular hypertrophy, detraining, left ventricular remodeling, left ventricular wall thickness, elite athletes, body weight, leisure-time physical activity
- MeSH terms
- Adaptation, Physiological, Adult, Aging, Cardiac Volume, Cardiomyopathy, Dilated, Cardiomyopathy, Hypertrophic, Diagnosis, Differential, Echocardiography, Electrocardiography, Heart Ventricles, Humans, Longitudinal Studies, Male, Physical Fitness, Rome, Sports, Stroke Volume, Time, Reproducibility of Results, Observer Variation, Ventricular Function, Hypertrophy, Left Ventricular, Cardiovascular Deconditioning
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