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Intensive Hospital Monitoring of Adverse Reactions to Drugs
Open accessAbstract
A total of 1,268 patients admitted to hospital wards were kept under surveillance by one observer throughout their stay in hospital. All drugs given to them and the occurrence of adverse reactions were recorded. Drug reactions were found in 10·2% of the 1,160 patients who received drug therapy. Most reactions were due to known pharmacological actions of the drugs. Though only four reactions were of life-threatening seriousness, 80% of the 129 reactions observed were of moderate severity. Digitalis preparations, bronchodilator drugs, and ampicillin had the highest reaction rates. It is suggested that larger surveys of adverse reactions in relation to drug usage would make a useful contribution to the problem.
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Citations
Cited by
Incidence of Adverse Drug Reactions in Hospitalized Patients: A Meta-analysis of Prospective Studies
Lazarou, J., Pomeranz, B. H., & Corey, P. N. (1998) · JAMA · doi:10.1001/jama.279.15.1200 · Cited by 4,807
Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients
Pirmohamed, M., James, S., Meakin, S., Green, C., Scott, A. K., Walley, T. J., Farrar, K., Park, B. K., & Breckenridge, A. M. (2004) · BMJ · doi:10.1136/bmj.329.7456.15 · Cited by 3,230
Predisposing Factors in Adverse Reactions to Drugs
Hurwitz, N. (1969) · BMJ · doi:10.1136/bmj.1.5643.536 · Cited by 434
Self-citationDrug-Induced Illness Leading to Hospitalization
Caranasos, G. J. (1974) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1974.03230310023021 · Cited by 358
Spindelegger, C. J., Papageorgiou, K., Grohmann, R., Engel, R., Greil, W., Konstantinidis, A., Agelink, M. W., Bleich, S., Ruether, E., Toto, S., et al. (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu080 · Cited by 82
Metadata
- Authors
- Hurwitz, N., & Wade, O. L.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1969-03-01
- Volume
- 1
- Issue
- 5643
- Pages
- 531-536
- ISSN
- 0007-1447 (ISSN-L)
- 1468-5833
- OpenAlex
- W1977842380
- Cited by
- 294
- References
- 0
- FWCI
- 23.48
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
