The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Nitrazepam: lastingly effective but trouble on withdrawal.
Open accessAbstract
The sleep of 10 volunteers with an average age of 57 years was recorded electrophysiologically before, during, and after nitrazepam 5 mg nightly for 10 weeks. Sleep was longer and less broken on the drug and no tolerance was obvious after two months' use. Withdrawal of the drug, however, caused sleep to be temporarily worse than before the drug had been taken. Slow-wave sleep was reduced by nitrazepam, but the accompanying secretion of growth hormone was not impaired.
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“The prevalence of rebound insomnia was found to be significantly lower in all benzodiazepines compared to triazolam [52, 60-69] and was lower than that with triazolam.”
From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [52]
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“triazolo benzodiazepine, alprazolam, were found to be at higher risk of continuous and high-dose use.”
From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [52]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
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“In contrast, anxiolytic benzodiazepines, in particular, clobazam and clonazepam, were found to be significantly less problematic having lower risk of high-dose use [52].”
From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [52]
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Citations
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Cited by
Guidelines for the Rational Use of Benzodiazepines: When and What to Use
Ashton, H. (1994) · Drugs · doi:10.2165/00003495-199448010-00004 · Cited by 593
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Metadata
- Authors
- Adam, K., Adamson, L., Brezinova, V, & Hunter, W. M.
- ORCID
- Adamson, L
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1976-06-26
- Volume
- 1
- Issue
- 6025
- Pages
- 1558-1560
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- OpenAlex
- W1996341365
- Cited by
- 90
- References
- 16
- Citations by year
- 2023: 1 · 2020: 1 · 2018: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 9.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Keywords
- nitrazepam, benzodiazepines, hypnotics, sleep, slow-wave sleep, drug withdrawal, tolerance (pharmacology and immunology), growth hormone secretion, elderly volunteers
- MeSH terms
- Adult, Female, Humans, Male, Middle Aged, Nitrazepam, Sleep, Sleep Stages, Sleep, REM, Growth Hormone, Substance Withdrawal Syndrome
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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