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Cited by 426

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Immediate heart-rate response to standing: simple test for autonomic neuropathy in diabetes.

Open access
Ewing, D J, Campbell, I W, Murray, A, Neilson, J M, Clarke, B F·1978·BMJ

Abstract

The immediate heart-rate response to standing was measured in 22 normal controls and 25 patients with diabetes, 15 of whom had autonomic neuropathy. The response in the controls and patients without autonomic neuropathy was characteristic and consistent, with tachycardia maximal at around the 15th beat and relative bradycardia maximal at around the 30th beat. The diabetics with autonomic neuropathy, however, showed a flat response. In three controls the response was abolished with intravenous atropine but not with propranolol, showing that it is mediated through the vagus. A simplified test using routine ECGs and measuring the R-R interval at beats 15 and 30 with a ruler is easily performed as an outpatient procedure and may be used as a measure of autonomic function in diabetes.

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Metadata

Authors
Ewing, D. J., Campbell, I. W., Murray, A., Neilson, J. M., & Clarke, B. F.
Venue
BMJ
Publisher
BMJ
Published
1978-01-21
Volume
1
Issue
6106
Pages
145-147
ISSN
  • 0007-1447 (ISSN-L)
  • 1468-5833
OpenAlex
W2081677547
Cited by
426
References
1
FWCI
13.29
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Immediate heart-rate response to standing: simple test for autonomic neuropathy in diabetes. https://app.cochat.ai/papers/10.1136/bmj.1.6106.145
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Ewing, D. J., Campbell, I. W., Murray, A., Neilson, J. M., & Clarke, B. F. (1978). Immediate heart-rate response to standing: simple test for autonomic neuropathy in diabetes. BMJ. https://doi.org/10.1136/bmj.1.6106.145

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