Autonomic nerve function in rheumatoid arthritis of varying severity
Abstract
Autonomic nerve function was evaluated by deep breathing and tilt table tests in 17 patients with rheumatoid arthritis (RA) and in 24 healthy control subjects. The results showed that all RA patients had increased heart rates at rest, irrespective of the severity of the disease. Patients with severe RA had increased systolic and diastolic blood pressures before and after tilting. Pronounced abnormalities in the immediate heart rate reaction to tilting indicating autonomic neuropathy (AN) were also demonstrated in patients with severe RA. The abnormal immediate reaction to tilting was mainly the result of vagal neuropathy. From the present study it is evident that severe RA may be accompanied by AN and the consequences need to be elucidated.
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Some studies have indicated that patients with chronic inflammatory diseases have an increased activity of the sympathetic nervous system.
“Some studies have indicated that patients with chronic inflammatory diseases have an increased activity of the SNS.”
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- Authors
- Leden, I., Eriksson, A., Lilja, B., Sturfelt, G., & Sundkvist, G.
- Affiliations
- Centralsjukhuset Kristianstad (SE)
- Lund University (SE)
- Skåne University Hospital (SE)
- Venue
- Scandinavian Journal of Rheumatology
- Publisher
- Informa UK Limited
- Published
- 1983-01
- Volume
- 12
- Issue
- 2
- Pages
- 166-170
- ISSN
- 0300-9742 (ISSN-L)
- 1502-7732
- OpenAlex
- W2123312727
- Cited by
- 81
- References
- 17
- Citations by year
- 2024: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Rheumatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Keywords
- rheumatoid arthritis, autonomic neuropathy, autonomic nervous system activity, heart rate, blood pressure, tilt table test, deep breathing test, disease severity
- MeSH terms
- Adult, Aged, Antibodies, Antinuclear, Arthritis, Rheumatoid, Autonomic Nervous System, Blood Pressure, Electrocardiography, Female, Heart Rate, Humans, Male, Middle Aged, Posture, Respiration
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